Role of obesity related inflammation in pathogenesis of peripheral artery disease in patients of type 2 diabetes mellitus

Yadav, U.S.; Kumar, Nilesh; Sarvottam, Kumar

doi:10.1007/s40200-023-01221-5

Cited by 2 publications

(3 citation statements)

References 169 publications

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“…Inflammation is considered a significant risk marker for systemic atherosclerosis and is also a prominent feature of vascular complications induced by diabetes [ 2 , 79 ]. Adipocytokines, such as TNF-α and IL-6, negatively impact insulin signaling by activating inflammatory pathways and ER stress [ 80 ]. This state of insulin resistance not only disrupts glucose homeostasis but also further impairs EC function, leading to dysregulation of vascular constriction and dilation [ 80 ].…”

Section: Pathophysiological Mechanisms Of Macrovascular Complications...mentioning

confidence: 99%

“…Adipocytokines, such as TNF-α and IL-6, negatively impact insulin signaling by activating inflammatory pathways and ER stress [ 80 ]. This state of insulin resistance not only disrupts glucose homeostasis but also further impairs EC function, leading to dysregulation of vascular constriction and dilation [ 80 ]. This dysregulation elevates the risk of cardiovascular and cerebrovascular diseases, thereby exacerbating the overall pathological condition of T2DM patients.…”

Section: Pathophysiological Mechanisms Of Macrovascular Complications...mentioning

confidence: 99%

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Advances in secondary prevention mechanisms of macrovascular complications in type 2 diabetes mellitus patients: a comprehensive review

Guan,

Tian,

Wang

et al. 2024

Eur J Med Res

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Type 2 diabetes mellitus (T2DM) poses a significant global health burden. This is particularly due to its macrovascular complications, such as coronary artery disease, peripheral vascular disease, and cerebrovascular disease, which have emerged as leading contributors to morbidity and mortality. This review comprehensively explores the pathophysiological mechanisms underlying these complications, protective strategies, and both existing and emerging secondary preventive measures. Furthermore, we delve into the applications of experimental models and methodologies in foundational research while also highlighting current research limitations and future directions. Specifically, we focus on the literature published post-2020 concerning the secondary prevention of macrovascular complications in patients with T2DM by conducting a targeted review of studies supported by robust evidence to offer a holistic perspective.

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Section: Pathophysiological Mechanisms Of Macrovascular Complications...mentioning

confidence: 99%

Section: Pathophysiological Mechanisms Of Macrovascular Complications...mentioning

confidence: 99%

Advances in secondary prevention mechanisms of macrovascular complications in type 2 diabetes mellitus patients: a comprehensive review

Guan,

Tian,

Wang

et al. 2024

Eur J Med Res

View full text Add to dashboard Cite

show abstract

“…Diabetes is primarily categorized into three types, namely (1) TIDM (pancreas don't produce insulin), (2) TIIDM (body cells develop resistance to insulin or less expression of insulin over time), and (3) gestational diabetes (happens during pregnancy) [3,4]. About 49.7% of people around the world are reported to be living with undiagnosed TIIDM, with an average life expectancy decreased by approximately 10 years.…”

Section: Introductionmentioning

confidence: 99%

Clinical Biomarkers of Dyslipidemia in Diabetes Mellitus Type II Patients

Afzal,

Kausar,

Aslam

et al. 2024

BioSci Rev.

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Background. This study aims to comparatively investigate the clinical biomarkers of diabetic dyslipidemia in type II diabetes mellitus (TIIDM) patients and healthy controls with no clinical diabetic history. Method. A cross-sectional study was conducted on 100 TIIDM patients age-matched with 100 control subjects. They were evaluated from January 2021 to July 2022 in Narowal, Pakistan. Various biomarkers including total cholesterol (TL), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides were measured for each subject. Results. The results showed significantly higher levels of TC (238 ± 30 mg/dl), triglycerides (201 ± 72 mg/dl), and LDL (141 ± 47 mg/dl) in TIIDM patients as compared to control groups’ levels of TC (167 ± 23 mg/dl), triglycerides (175 ± 75 mg/dl), and LDL (95 ± 30 mg/dl). However, HDL level was significantly lower (46 ± 21 mg/dl) in TIIDM patients as compared to control group (54 ± 27 mg/dl). Conclusion. The clinical biomarkers of dyslipidemia are effective risk predictors for cardiovascular diseases in low-income countries such as Pakistan.

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Role of obesity related inflammation in pathogenesis of peripheral artery disease in patients of type 2 diabetes mellitus

Cited by 2 publications

References 169 publications

Advances in secondary prevention mechanisms of macrovascular complications in type 2 diabetes mellitus patients: a comprehensive review

Advances in secondary prevention mechanisms of macrovascular complications in type 2 diabetes mellitus patients: a comprehensive review

Clinical Biomarkers of Dyslipidemia in Diabetes Mellitus Type II Patients

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