Role of Obesity and Mediators of Adipose Tissue in Renal Transplant and Disease
Sonia Mota-Zamorano,
Guadalupe García-Pino,
Guillermo Gervasini
Abstract:This review provides insight into the role that obesity, but especially mediators of the adipose tissue, have in both renal disease and transplantation. In particular, we focus on the functions of leptin and adiponectin, inflammatory mediators with widely known clinical implications, as well as on the role of arachidonic acid-derived eicosanoid metabolites. These latter compounds, epoxyeicosatrienoic (EETs) and hydroxyeicosatetraenoic (HETEs) acids, which modulate the liberation of cytokines in the adipose tis… Show more
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