Role of Nutrients and Foods in Attenuation of Cardiac Remodeling through Oxidative Stress Pathways

Abstract

Cardiac remodeling is defined as a group of molecular, cellular, and interstitial changes that manifest clinically as changes in the heart’s size, mass, geometry, and function after different injuries. Importantly, remodeling is associated with increased risk of ventricular dysfunction and heart failure. Therefore, strategies to attenuate this process are critical. Reactive oxygen species and oxidative stress play critical roles in remodeling. Importantly, antioxidative dietary compounds potentially have protective properties against remodeling. Therefore, this review evaluates the role of nutrients and food as modulators of cardiac remodeling.

Oxidants and Cardiorenal Vascular Remodeling—Insights from Rare Genetic Tubulopathies: Bartter’s and Gitelman’s Syndromes

“…As detailed above, the complex array of altered pathways and ROS-related effects found in GSBS clearly must combine to block the pathological effects typically associated with an elevated Ang II. The myriad of oxidants, as well as changes in their levels, alongside the multiple pathways, organelles and organ systems involved found in GSBS patients, provides a rationale for why treatments aimed solely at “oxidants” have proven mostly unsuccessful on clinical grounds [ 43 , 44 ]. However, blocking multiple Ang II dependent signals, such as via blocking AT1R and ROCK activity, for example, does lead to the improvement of cardiovascular–renal remodeling, in part via a reduction of oxidative stress [ 18 , 45 , 46 ].…”