Role of nuclear and membrane estrogen signaling pathways in the male and female reproductive tract

Cooke, Paul S.; Mesa, Ana M.; Sirohi, Vijay Kumar; Levin, Ellis R.

doi:10.1016/j.diff.2020.11.002

Cited by 13 publications

(3 citation statements)

References 95 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present, E2 has been found to increase the expression of cRLN3 ( Figure 7D ). As a sex steroid hormone, E2 is mainly secreted by the growing follicles and the ovary, which play an important role in female reproduction, including acting as the growth factor for reproductive organs’ growth ( Cooke et al, 1998 ; Cooke et al, 2021 ), triggering hypothalamic events via a positive feedback system ( Micevych et al, 2008 ; Micevych and Sinchak, 2011 ), and maintaining follicle growth and maturation ( Britt et al, 2004 ; Drummond, 2006 ; Padmanabhan et al, 2018 ). The findings that cRLN3 is involved in female reproductive biology are in line with the report that female teleost fish that RLN3 promotes the production of E2 during follicular development ( Wilson et al, 2009 ; Yang et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Characterization of relaxin 3 and its receptors in chicken: Evidence for relaxin 3 acting as a novel pituitary hormone

Zheng²,

Jiang³

et al. 2022

Front. Physiol.

View full text Add to dashboard Cite

Mammalian relaxin (RLN) family peptides binding their receptors (RXFPs) play a variety of roles in many physiological processes, such as reproduction, stress, appetite regulation, and energy balance. In birds, although two relaxin family peptides (RLN3 and INSL5) and four receptors (RXFP1, RXFP2, RXFP2-like, and RXFP3) were predicated, their sequence features, signal properties, tissue distribution, and physiological functions remain largely unknown. In this study, using chickens as the experimental model, we cloned the cDNA of the cRLN3 gene and two receptor (cRXFP1 and cRXFP3) genes. Using cell-based luciferase reporter assays, we demonstrate that cRLN3 is able to activate both cRXFP1 and cRXFP3 for downstream signaling. cRXFP1, rather than cRXFP3, is a cognate receptor for cRLN3, which is different from the mammals. Tissue distribution analyses reveal that cRLN3 is highly expressed in the pituitary with lower abundance in the hypothalamus and ovary of female chicken, together with the detection that cRLN3 co-localizes with pituitary hormone genes LHB/FSHB/GRP/CART and its expression is tightly regulated by hypothalamic factors (GnRH and CRH) and sex steroid hormone (E2). The present study supports that cRLN3 may function as a novel pituitary hormone involving female reproduction.

show abstract

Section: Discussionmentioning

confidence: 99%

Characterization of relaxin 3 and its receptors in chicken: Evidence for relaxin 3 acting as a novel pituitary hormone

Zheng²,

Jiang³

et al. 2022

Front. Physiol.

View full text Add to dashboard Cite

show abstract

“…In the nucleus, this complex binds to specific genomic deoxyribonucleic acid (DNA) motifs known as estrogen response elements (EREs). In addition, similar to AR, ERs quickly initiate nongenomic functions by adhering to the cell membrane and activating a series of signalling cascades [ 40 , 41 ].…”

Section: Roles Of Erα and Erβ In Castration-resistant Prostate Cancermentioning

confidence: 99%

The Role of ERα and ERβ in Castration-Resistant Prostate Cancer and Current Therapeutic Approaches

et al. 2023

View full text Add to dashboard Cite

Castration-resistant prostate cancer, or CRPC, is an aggressive stage of prostate cancer (PCa) in which PCa cells invade nearby or other parts of the body. When a patient with PCa goes through androgen deprivation therapy (ADT) and the cancer comes back or worsens, this is called CRPC. Instead of androgen-dependent signalling, recent studies show the involvement of the estrogen pathway through the regulation of estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) in CRPC development. Reduced levels of testosterone due to ADT lead to low ERβ functionality in inhibiting the proliferation of PCa cells. Additionally, ERα, which possesses androgen independence, continues to promote the proliferation of PCa cells. The functions of ERα and ERβ in controlling PCa progression have been studied, but further research is needed to elucidate their roles in promoting CRPC. Finding new ways to treat the disease and stop it from becoming worse will require a clear understanding of the molecular processes that can lead to CRPC. The current review summarizes the underlying processes involving ERα and ERβ in developing CRPC, including castration-resistant mechanisms after ADT and available medication modification in mitigating CRPC progression, with the goal of directing future research and treatment.

show abstract

“…The LBD domain is responsible for interacting with estrogen and several transcriptional cofactors to control ERα signaling activity [ 8 ]. If ERα is activated by estrogen, the ERα protein can shuttle into the nucleus and bind to cis-regulatory DNA regions in the genome, which promotes the expression of ERα target gene such as TFF1 and GREB1 to enhance breast cancer progression [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

The ubiquitin ligase RNF2 stabilizes ERα and modulates breast cancer progression

Yang

et al. 2022

Human Cell

View full text Add to dashboard Cite

Estrogen receptor α (ERα) is the most common clinical marker used for breast cancer prognosis and the classification of breast cancer subtypes. Clinically, patients with estrogen receptor-positive breast cancer can receive endocrine therapy. However, resistance to endocrine therapy has become an urgent clinical problem. A large number of previous studies have proven that posttranslational modification of the estrogen receptor is significantly related to endocrine therapy resistance. RNF2 is a member of the RING finger protein family that functions as an E3 ubiquitin ligase. Several studies have clarified that RNF2 is a critical regulator of ERα transcriptional regulation. In our current study, we identified RNF2 as an important posttranslational modification regulator of the estrogen receptor. RNF2 depletion inhibited breast cancer cell progression and ERα signaling activity. TCGA data analysis indicated that RNF2 was elevated in breast malignancies, while RNF2 depletion could drastically inhibit estrogen response gene expression on a whole-genome scale. TCGA data analysis revealed that RNF2 was positively correlated with ERα target gene expression. Further mechanistic studies showed that RNF2 was mainly localized in the nucleus and associated with ERα. The association increased ERα stability by inhibiting ERα K48-linked polyubiquitination. In conclusion, our study implicates nongenomic regulation by RNF2 on ERα protein stability and suggests that targeting RNF2 could be a promising strategy for breast cancer treatments.

show abstract

Role of nuclear and membrane estrogen signaling pathways in the male and female reproductive tract

Cited by 13 publications

References 95 publications

Characterization of relaxin 3 and its receptors in chicken: Evidence for relaxin 3 acting as a novel pituitary hormone

Characterization of relaxin 3 and its receptors in chicken: Evidence for relaxin 3 acting as a novel pituitary hormone

The Role of ERα and ERβ in Castration-Resistant Prostate Cancer and Current Therapeutic Approaches

The ubiquitin ligase RNF2 stabilizes ERα and modulates breast cancer progression

Contact Info

Product

Resources

About