Role of NSAIDs in acute treatment of headache

Martelletti, Paolo; Farinelli, Ivano; Coloprisco, Gabriella; Patacchioli, Francesca Romana

doi:10.1002/ddr.20191

Cited by 8 publications

(3 citation statements)

References 49 publications

(41 reference statements)

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“…Non-pharmacological treatment encompasses lifestyle modifications, dietary adjustments, psychological therapy, physical therapy, etc., whereas pharmacological treatment involves the administration of non-steroidal anti-inflammatory drugs, tricyclic antidepressants, analgesics, etc. ( Martelletti et al, 2007 ; Smitherman et al, 2011 ; Licina et al, 2023 ). Studies indicate that the efficacy of either non-pharmacological or pharmacological treatment alone is limited ( Grazzi et al, 2007 ).…”

Section: Introductionmentioning

confidence: 99%

Research hotspots and trends on acupuncture treatment for headache: a bibliometric analysis from 2003 to 2023

Zhao,

Hu,

Luo

et al. 2024

Front. Neurosci.

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BackgroundWhile acupuncture treatment has gained extensive usage in addressing headaches, there remains a notable gap in the literature analysis for this field. Therefore, this study aims to conduct a literature review using Citespace, VOSviewer, and Bibliometrix, aiming to examine the current status, strengths, and potential future directions in the utilization of acupuncture for headache treatment.MethodsRelevant literature on acupuncture treatment for headaches between 2003 and 2023 was retrieved from the Web of Science (WoS) core database. Utilizing CiteSpace 6.1.R6, VOSviewer 1.6.18, and Bibliometrix 4.1.4, we conducted bibliometric analyses across various categories, including countries/regions, institutions, authors, journals, references, and keywords.ResultsA total of 808 research reports were included. China and the United States have significantly contributed to this field. Chengdu University of Chinese Medicine holds the record for the highest number of published papers. Liu Lu has the highest publication output, while Linde K has the highest citation rate. MEDICINE leads in publication frequency, while CEPHALALGIA holds the highest citation rate. The Long-term Effect of Acupuncture for Migraine Prophylaxis a Randomized Clinical Trial is the most cited reference. Migraine was the most researched type. Filiform needle acupuncture was the most widely used stimulation method. The safety and efficacy of acupuncture have received significant attention. Modern mechanism research shows that depression, brain functional connectivity, and neuroimaging technology have become research hotspots in the acupuncture treatment of headaches.ConclusionAcupuncture treatment for headaches has established a stable trend with a promising developmental trajectory. Research in this field mainly focuses on different acupuncture prevention and treatment for various types of headaches, the safety and efficacy of acupuncture, etc. Research on the mechanism of action mainly focuses on interpreting bidirectional and holistic regulation between pain and emotion by acupuncture and the regulation of brain function connection and neuroimaging technology by acupuncture. Future research should expand on the advantages and indications of acupuncture treatment for different headaches and their modern mechanisms.

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Section: Introductionmentioning

confidence: 99%

Research hotspots and trends on acupuncture treatment for headache: a bibliometric analysis from 2003 to 2023

Zhao,

Hu,

Luo

et al. 2024

Front. Neurosci.

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“…1,2 They have notably applications as anti-pyretics, 3 pain killers, 4 and anti-arthritics. 5 It is hypothesized that the action mechanism of anti-inflammatory drugs is mainly based on the inhibition of cyclooxygenases (COX), 6 noted also as prostaglandin synthetase, a key enzyme in the metabolism of arachidonic acid to prostaglandin.…”

Section: Introductionmentioning

confidence: 99%

Crystal and molecular structure of β‐cyclodextrins functionalized with the anti‐inflammatory drug Etodolac

et al. 2009

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The conjugates of beta-cyclodextrins with R- or with S-Etodolac were characterized by NMR spectroscopy, and S-Etodolac alone was characterized by X-ray diffraction analysis. In solution, the R-Etodolac conjugate is soluble in water; the other epimer shows a very low solubility. The NMR characterization of the R-Etodolac conjugate in D(2)O shows that, in aqueous solution, the Edotolac moiety is self-included in the cavity, while the NMR characterization in MeOH of both conjugates underlines that, in this solvent, the Etodolac moiety is not included in the CD cavity. The X-ray structure determination of the S-Etodolac conjugate reveals a "sleeping swan"-like shape, with the covalently bonded Etodolac moiety being folded with the 8-ethyl group inserted inside the hydrophobic cavity of the beta-CD ring. The terminal methyl group of the 8-ethyl group enters the centre of cavity from the side of the primary hydroxyl groups and is buried inside the beta-CD macrocycle. The terminal methyl group is positioned at a distance of 1.06 A from the O(4) plane in the side of the primary hydroxyl groups. In addition to van der Waals interactions between the hydrophobic ethyl group and the beta-CD cavity, the folded conformation is further stabilized by one intramolecular H-bond involving the indole N-H group and the primary hydroxyl group of the glucose unit 7. Along the b axis, the beta-CD molecules are arranged in columns; the macrocycles form a herring bone pattern, so that the cavity of each beta-CD molecule is closed at each end by neighboring molecules. Within the layers, the beta-CD macrocycles are held together by a complicated intermolecular hydrogen bond network, in which numerous water molecules and hydroxyl groups are involved.

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“…Sumatriptan constitutes the archetype of a new class of specific molecules with abortive action, namely triptans, which have now reached their seventh molecule. At present, nonsteriodal anti-inflammatory drugs (NSAIDs) still represent the most common drugs used in acute migraine therapy [5,6].…”

Section: Introductionmentioning

confidence: 99%

Future drugs for migraine

et al. 2009

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Migraine is a complex, neurovascular disorder in which genetic and environmental factors interact. At present, frontline therapies in the acute treatment of migraine include the use of non-steroidal anti-inflammatory drugs and triptans. Evidence indicates that calcitonin gene-related peptide (CGRP) plays a fundamental role in the mechanism of migraine. CGRP is a strong vasodilatatory neuropeptide that is released from activated trigeminal sensory nerves. The development of CGRP antagonists has also been driven by the fact that triptans are vasoconstrictive and cannot be safely used in patients with cardiovascular risk factors. Olcegepant (BIBN4096) is the first CGRP antagonist for the treatment of migraine that has been tested in clinical trials, but because of its poor oral bioavailability, only the intravenous formulation has been tested. The first oral non-peptide CGRP antagonist, telcagepant, has been shown recently to be highly effective in the treatment of migraine attacks. This development can be considered as the most important pharmacological breakthrough for migraine treatment since the introduction of sumatriptan in the early 1990s. These results are also of importance, since they support an interesting pathophysiological hypothesis of migraine. The pipeline of future compounds for the treatment of acute migraine headaches include TPRV1 antagonists, prostaglandin E receptor 4 (EP(4)) receptor antagonists, serotonin 5HT1(F) receptor agonists and nitric oxide synthase inhibitors. The immediate future of a preventative treatment for migraine headaches is well represented by botulinum toxin type-A, glutamate NMDA receptor antagonists, gap-junction blocker tonabersat and an angiotensin type 1 blocker candesartan.

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Role of NSAIDs in acute treatment of headache

Cited by 8 publications

References 49 publications

Research hotspots and trends on acupuncture treatment for headache: a bibliometric analysis from 2003 to 2023

Research hotspots and trends on acupuncture treatment for headache: a bibliometric analysis from 2003 to 2023

Crystal and molecular structure of β‐cyclodextrins functionalized with the anti‐inflammatory drug Etodolac

Future drugs for migraine

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