2023
DOI: 10.2152/jmi.70.343
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Role of Nrf2 signaling in development of hepatocyte-like cells

Chie Takasu,
Shuhai Chen,
Luping Gao
et al.

Abstract: Generation of hepatocytes from human adipose-derived mesenchymal stem cells (hADSCs) could be a promising alternative source of human hepatocytes. However, mechanisms to differentiate hepatocytes from hADSCs are not fully elucidated. We have previously demonstrated that our three-step differentiation protocol with glycogen synthase kinase (GSK) 3 inhibitor was effective to improve hepatocyte functions. In this study, we investigated the activation of the nuclear factor erythroid-2 related factor 2 (Nrf2) on hA… Show more

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