Role of NQO1 609C&gt;T and NQO2 −3423G&gt;A gene polymorphisms in esophageal cancer risk in Kashmir valley and meta analysis

Malik, Manzoor Ahmad; Zargar, Showkat Ali; Mittal, Balraj

doi:10.1007/s11033-012-1781-y

Cited by 25 publications

(14 citation statements)

References 31 publications

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“…Furthermore, NQO2 was reported to regulate the stability of cyclin D1 in CWR22Rv1 prostate cancer cells by AKT/GSK‐3 β signal pathway . In addition, NQO2 polymorphism was strongly associated with esophageal cancer and the lymph node metastasis of papillary thyroid microcarcinoma . NQO2 was mostly shown to be a negative modifier of carcinogenesis in breast cancer , skin neoplasms prostate cancer , radiation‐induced B‐cell lymphomas and melanoma while only one study suggested it to be a susceptibility gene for breast carcinogenesis .…”

Section: Discussionmentioning

confidence: 99%

Genome‐wide analysis of long noncoding RNA (lncRNA) expression in colorectal cancer tissues from patients with liver metastasis

et al. 2016

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The liver is the most frequent site of metastasis in colorectal cancer (CRC), in which long noncoding RNAs (lncRNAs) may play a crucial role. In this study, we performed a genome‐wide analysis of lncRNA expression to identify novel targets for the further study of liver metastasis in CRC. Samples obtained from CRC patients were analyzed using Arraystar human 8 × 60K lncRNA/mRNA v3.0 microarrays chips to find differentially expressed lncRNAs and mRNAs. The results were confirmed by quantitative reverse transcription‐polymerase chain reaction (qRT‐PCR). The differentially expressed lncRNAs and mRNAs were identified through fold change filtering. Gene ontology (GO) and pathway analyses were performed using standard enrichment computational methods. In the CRC tissues from patients with liver metastasis, 2636 lncRNAs were differentially expressed, including 1600 up‐regulated and 1036 down‐regulated over two‐fold compared with the CRC tissues without metastasis. Among the 1584 differentially expressed mRNAs, 548 were up‐regulated and 1036 down‐regulated. GO and pathway analysis of the up‐regulated and down‐regulated mRNAs yielded different results. The up‐regulated mRNAs were associated with single‐organism process (biological process), membrane part (cellular component), and transporter activity (molecular function), whereas the down‐regulated mRNAs were associated with cellular process, membrane, and binding, respectively. In the pathway analysis, 27 gene pathways associated with the up‐regulated mRNAs and 51 gene pathways associated with the down‐regulated mRNAs were targeted. The significant changes in NQO2 (NM_000904) mRNA and six associated lncRNAs were selected for validation by qRT‐PCR. Aberrantly expressed lncRNAs may play an important role in the liver metastasis of CRC. The further study can provide useful insights into the biology and, ultimately, the prevention of liver metastasis.

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Section: Discussionmentioning

confidence: 99%

Genome‐wide analysis of long noncoding RNA (lncRNA) expression in colorectal cancer tissues from patients with liver metastasis

et al. 2016

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“…Some studies have shown that the polymorphism in the NQO1 gene affects the translation of the NQO1 protein. The NQO1 C609T polymorphism has been reported to be associated with an increased risk of various cancers such as renal [21], lung [22], esophageal [23], gastric [24] and head and neck [25]. Hu’ results indicated that functional polymorphisms in NQO1 SNP609 associate with the risk of cervical cancer especially in women infected with type 16- and/or type 18-related HPVs [26].…”

Section: Discussionmentioning

confidence: 99%

NQO1 overexpression is associated with poor prognosis in squamous cell carcinoma of the uterine cervix

Kong

Yan

et al. 2014

BMC Cancer

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BackgroundNQO1 (NAD(P)H: quinone oxidoreductase-1), located on chromosome 16q22, functions primarily to protect normal cells from oxidant stress and electrophilic attack. Recent studies have revealed that NQO1 is expressed at a high level in most human solid tumors including those of the colon, breast, pancreas, ovaries and thyroid, and it has also been detected following the induction of cell cycle progression and proliferation of melanoma cells. In this study, we aimed to investigate the clinicopathological significance of upregulated NQO1 protein expression in squamous cell carcinomas (SCCs) of the uterine cervix.MethodsThe localization of the NQO1 protein was determined in the SiHa cervical squamous cancer cell line using immunofluorescence (IF) staining, and immunohistochemical (IHC) staining performed on paraffin-embedded cervical SCC specimens from 177 patients. For comparison, 94 cervical intraepithelial neoplasia (CIN) and 25 normal cervical epithelia samples were also included. QRT-PCR was performed on RNA from fresh tissues to detect NQO1 mRNA expression levels, and HPV infection status was genotyped using oligonucleotide microarray. Disease-free survival (DFS) and 5-year overall survival (OS) rates for all cervical SCC patients were calculated using the Kaplan–Meier method, and univariate and multivariate analysis was performed using the Cox proportional hazards regression model.ResultsThe NQO1 protein showed a mainly cytoplasmic staining pattern in cervical cancer cells, and only three cases of cervical SCC showed a nuclear staining pattern. The strongly positive rate of NQO1 protein expression was significantly higher in cervical SCCs and CINs than in normal cervical epithelia. High-level NQO1 expression was closely associated with poor differentiation, late-stage, lymph node metastasis and high-risk for HPV infection. Additionally, high-level NQO1 expression was associated with lower DFS and 5-year OS rates, particularly for patients with early-stage cervical SCCs. Furthermore, Cox analysis revealed that NQO1 expression emerged as a significant independent hazard factor for DFS rate in patients with cervical SCC.ConclusionsNQO1 overexpression might be an independent biomarker for prognostic evaluation of cervical SCCs.

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“…The Ser variant of NQO1 rs1800566 encoding p.Pro187Ser has reduced enzymatic activity [34, 35] and is associated with higher benzene toxicity compared with the Pro variant [36]. This NQO1 SNP was associated with esophageal adenocarcinoma risk and synergistically interacted (OR interaction = 1.16) with a promoter SNP of NQO2 , rs2070999, which was not associated with esophageal adenocarcinoma risk [37]. The functional role of this NQO2 SNP in gastrointestinal cancer remains to be elucidated.…”

Section: Epistasis Of Genome Instability and Mutationmentioning

confidence: 99%

Gene-gene interactions in gastrointestinal cancer susceptibility

et al. 2016

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Cancer arises from complex, multi-layer interactions between diverse genetic and environmental factors. Genetic studies have identified multiple loci associated with tumor susceptibility. However, little is known about how germline polymorphisms interact with one another and with somatic mutations within a tumor to mediate acquisition of cancer traits. Here, we survey recent studies showing gene-gene interactions, also known as epistases, affecting genetic susceptibility in colorectal, gastric and esophageal cancers. We also catalog epistasis types and cancer hallmarks with respect to the interacting genes. A total of 22 gene variation pairs displayed all levels of statistical epistasis, including synergistic, redundant, suppressive and co-suppressive interactions. Five genes primarily involved in base excision repair formed a linear topology in the interaction network, MUTYH-OGG1-XRCC1-PARP1-MMP2, and three genes in mTOR cell-proliferation pathway formed another linear network, PRKAG2-RPS6KB1-PIK3CA. Discrete pairwise epistasis was also found in nucleotide excision repair, detoxification, proliferation, TP53, TGF-β and other pathways. We propose that three modes of biological interaction underlie the molecular mechanisms for statistical epistasis. The direct binding, linear pathway and convergence modes can exhibit any level of statistical epistasis in susceptibility to gastrointestinal cancers, and this is likely true for other complex diseases as well. This review highlights the link between cancer hallmarks and susceptibility genes.

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Role of NQO1 609C>T and NQO2 −3423G>A gene polymorphisms in esophageal cancer risk in Kashmir valley and meta analysis

Cited by 25 publications

References 31 publications

Genome‐wide analysis of long noncoding RNA (lncRNA) expression in colorectal cancer tissues from patients with liver metastasis

Genome‐wide analysis of long noncoding RNA (lncRNA) expression in colorectal cancer tissues from patients with liver metastasis

NQO1 overexpression is associated with poor prognosis in squamous cell carcinoma of the uterine cervix

Gene-gene interactions in gastrointestinal cancer susceptibility

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