Role of noradrenergic transmission within the ventral bed nucleus of the stria terminalis in nicotine withdrawal‐induced aversive behavior

Arakaki, Saya; Minami, Masabumi

doi:10.1002/npr2.12252

Cited by 5 publications

(6 citation statements)

References 17 publications

(35 reference statements)

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“…Or, it might be that the threat-anticipation paradigm used here and in prior human psychophysiology studies is suboptimal ("wrong" human assay). Most of the anxiety assays used in rodent models of addictionconditioned-place avoidance, elevated-plus maze, open field, shock-probe burying-focus on instrumental defensive behaviors emitted over extended assessment periods (5-15 minutes) (Arakaki & Minami, 2022;George et al, 2007;Patel, Vishwakarma, Patel, & Jain, 2021;Qi et al, 2016;Zhao-Shea et al, 2015). In contrast, the Maryland Threat Countdown and other popular threat-anticipation assays (e.g., NPU, Pavlovian threat conditioning) are structured as randomly intermixed, relatively brief (5-90 s) periods of safety and threat (Grillon et al, 2007;.…”

Section: Kim Et Al Nicotine Abstinence Amplifies Withdrawal and Distr...mentioning

confidence: 99%

“…Among nicotine-dependent rodents, acute deprivation is associated with heightened signs of anxiety across a range of assays and defensive behaviors (e.g., shock-probe burying) (George et al, 2007). Focal perturbation studies show that nicotine deprivation-induced increases in anxiety-related behaviors and stress-induced reinstatement of nicotine use critically depend on specific molecular (e.g., corticotrophin-releasing hormone, CRH; norepinephrine) signaling mechanisms in the EAc, with overlapping effects evident for other addictive substances (Arakaki & Minami, 2022;Cohen et al, 2015;George et al, 2007;Koob, 2008;Yamada & Bruijnzeel, 2011). Yet the relevance of these tantalizing neurobiological discoveries to the complexities of the human brain and human withdrawal remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Acute nicotine abstinence amplifies subjective withdrawal symptoms and threat-evoked fear and anxiety, but not extended amygdala reactivity

Kim

Kaplan²,

Islam³

et al. 2022

Preprint

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Tobacco smoking imposes a staggering burden on public health, underscoring the urgency of developing a deeper understanding of the processes that maintain addiction. Clinical and experience-sampling data highlight the importance of anxious withdrawal symptoms, but the underlying neurobiology has remained elusive. Work in animals implicates the central extended amygdala (EAc), but the translational relevance of these discoveries remains speculative. Here we leveraged a randomized trial design, well-established threat-anticipation paradigm, and multidimensional battery of assessments to understand the consequences of 24-hour nicotine abstinence. The threat-anticipation paradigm had the expected consequences, amplifying subjective distress and arousal, and recruiting the canonical threat-anticipation network. Abstinence increased smoking urges and withdrawal symptoms, and potentiated threat-evoked distress, but had negligible consequences for EAc threat reactivity, raising questions about the translational relevance of prominent animal and human models of addiction. These observations provide a framework for conceptualizing nicotine abstinence and withdrawal, with implications for basic, translational, and clinical science.

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Section: Kim Et Al Nicotine Abstinence Amplifies Withdrawal and Distr...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Acute nicotine abstinence amplifies subjective withdrawal symptoms and threat-evoked fear and anxiety, but not extended amygdala reactivity

Kim

Kaplan²,

Islam³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Among nicotinedependent rodents, acute deprivation is associated with heightened signs of anxiety across a range of threat assays and defensive behaviors (e.g., shock-probe burying) [35]. Focal perturbation studies show that nicotine deprivation-induced increases in anxiety-related behaviors and stress-induced reinstatement of nicotine use critically depend on specific molecular (e.g., corticotrophin-releasing hormone, CRH; norepinephrine) signaling mechanisms in the EAc (Ce/ BST), with overlapping effects evident for other addictive substances [13,[35][36][37][38]]. Yet the relevance of these tantalizing neurobiological discoveries to the complexities of the human brain and human withdrawal remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Acute nicotine abstinence amplifies subjective withdrawal symptoms and threat-evoked fear and anxiety, but not extended amygdala reactivity

et al. 2023

View full text Add to dashboard Cite

Tobacco smoking imposes a staggering burden on public health, underscoring the urgency of developing a deeper understanding of the processes that maintain addiction. Clinical and experience-sampling data highlight the importance of anxious withdrawal symptoms, but the underlying neurobiology has remained elusive. Mechanistic work in animals implicates the central extended amygdala (EAc)—including the central nucleus of the amygdala and the neighboring bed nucleus of the stria terminalis—but the translational relevance of these discoveries remains unexplored. Here we leveraged a randomized trial design, well-established threat-anticipation paradigm, and multidimensional battery of assessments to understand the consequences of 24-hour nicotine abstinence. The threat-anticipation paradigm had the expected consequences, amplifying subjective distress and arousal, and recruiting the canonical threat-anticipation network. Abstinence increased smoking urges and withdrawal symptoms, and potentiated threat-evoked distress, but had negligible consequences for EAc threat reactivity, raising questions about the translational relevance of prominent animal and human models of addiction. These observations provide a framework for conceptualizing nicotine abstinence and withdrawal, with implications for basic, translational, and clinical science.

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“…CPA is often achieved by pairing a drug such as lithium to a compartment ( Cunningham and Niehus, 1993 ; Frisch et al, 1995 ; Longoni et al, 2011 ; Buffalari et al, 2016 ) or delivering a foot shock when the animal is in a specific compartment ( Buffalari et al, 2016 ; Barker et al, 2022 ). CPA is primarily quantified by comparing the time spent in the CS + during the posttest to the time spent in the CS + compartment at pretest ( Longoni et al, 2011 ; Buffalari et al, 2016 ; Arakaki and Minami, 2022 ; Peczely et al, 2022 ; Rezaei et al, 2022 ), but some studies compare the time spent in the CS + compartment to the time spent in the CS – compartment ( Li et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

Quantifying conditioned place preference: a review of current analyses and a proposal for a novel approach

Yates

2023

Front. Behav. Neurosci.

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Conditioned place preference (CPP) is used to measure the conditioned rewarding effects of a stimulus, including food, drugs, and social interaction. Because various analytic approaches can be used to quantify CPP, this can make direct comparisons across studies difficult. Common methods for analyzing CPP involve comparing the time spent in the CS+ compartment (e.g., compartment paired with drug) at posttest to the time spent in the CS+ compartment at pretest or to the CS– compartment (e.g., compartment paired with saline) at posttest. Researchers can analyze the time spent in the compartment(s), or they can calculate a difference score [(CS+post – CS+pre) or (CS+post – CS–post)] or a preference ratio (e.g., CS+post/(CS+post + CS–post)). While each analysis yields results that are, overall, highly correlated, there are situations in which different analyses can lead to discrepant interpretations. The current paper discusses some of the limitations associated with current analytic approaches and proposes a novel method for quantifying CPP, the adjusted CPP score, which can help resolve the limitations associated with current approaches. The adjusted CPP score is applied to both hypothetical and previously published data. Another major topic covered in this paper is methodologies for determining if individual subjects have met criteria for CPP. The paper concludes by highlighting ways in which researchers can increase transparency and replicability in CPP studies.

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Role of noradrenergic transmission within the ventral bed nucleus of the stria terminalis in nicotine withdrawal‐induced aversive behavior

Cited by 5 publications

References 17 publications

Acute nicotine abstinence amplifies subjective withdrawal symptoms and threat-evoked fear and anxiety, but not extended amygdala reactivity

Acute nicotine abstinence amplifies subjective withdrawal symptoms and threat-evoked fear and anxiety, but not extended amygdala reactivity

Acute nicotine abstinence amplifies subjective withdrawal symptoms and threat-evoked fear and anxiety, but not extended amygdala reactivity

Quantifying conditioned place preference: a review of current analyses and a proposal for a novel approach

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