Role of Non-High-Density Lipoprotein Cholesterol in Cerebrovascular Accidents

Abstract

BACKGROUNDThe role of non-high-density cholesterol (non-HDL-C) in cardiovascular events and cerebrovascular events remains a subject of controversy. We wanted to evaluate the role of non-HDL-C in stroke. METHODSOur cross-sectional study enrolled 100 participants with acute cerebrovascular accident (CVA) excluding traumatic CVA and CVA due to vasculitis. Institutional ethics committee approved the study and written informed consent was obtained from all study participants. Collected data included history, socio demographic parameters, examination findings and laboratory parameters. Non-HDL-C was calculated by deducting HDL-C from TC. Tests of significance were independent sample t test and Chi square test and a p <0.05 was considered statistically significant. RESULTSThe mean age of stroke was ~64 years, mean systolic and diastolic blood pressure were in the prehypertensive range. Significant association of serum LDL and non-HDL with ASCVD risk categorization was observed. CONCLUSIONSIncrease in incidence of stroke among young was observed with higher prevalence among males. Increasing burden of prehypertension and diabetes mellitus was observed among stroke patients. 20% participants had high serum non-HDL with normal serum LDL and 18% participants had high serum non-HDL with normal serum total cholesterol. Our study demonstrates the significance of non-HDL in acute stroke and might be a better predictor when used along with conventional investigations. Further studies on larger samples are required to demonstrate the usefulness of this parameter for predicting cerebrovascular accidents. KEYWORDSStroke, Non-HDL, ASCVD Risk, LDL HOW TO CITE THIS ARTICLE: Sechassayana N, Doraickannu T, James J. Role of non-high-density lipoprotein cholesterol in cerebrovascular accidents.