Role of non-coding RNAs in liver disease progression to hepatocellular carcinoma

Heo, Mi Jeong; Yun, Jun-Won; Kim, Sang Geon

doi:10.1007/s12272-018-01104-x

Cited by 49 publications

(37 citation statements)

References 164 publications

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“…An association of lncRNAs with metabolic disease has also been reported [1]. High expressions of lncRNAs in non-alcoholic steatohepatitis (NASH) patients showed that increased expressions of liver-specific lncRNA lnc18q22.2 were positively correlated with NASH grade and NAFLD score [42].…”

Section: Lncrnas Associated With Both Chronic Liver Disease and Hccmentioning

confidence: 88%

“…The data showed that mutations of both rs7763881 in HULC and rs619586 in MALAT1 were related to a decreased HCC risk. LncRNA levels were also increased in the patients with hepatitis C virus (HCV) infection [1]. HCV infection stimulates GAS5 and HOTAIR in HCV-infected liver cells [38,39].…”

Section: Lncrnas Associated With Both Chronic Liver Disease and Hccmentioning

confidence: 99%

“…An analysis of human lncRNAs from peripheral blood RNA identified that lncRNAs, such as AK128652 and AK054921, expressed in normal human plasma and liver, were significantly increased in patients with alcoholic cirrhosis [1]. These levels were inversely associated with the survival rate of patients with alcoholic cirrhosis [45].…”

Section: Lncrnas Associated With Both Chronic Liver Disease and Hccmentioning

confidence: 99%

“…The levels of HULC were positively correlated with HBV X protein (HBx) in HCC patients [1]. The activation of HULC promotes HBx-mediated cell proliferation by inducing p18 [46].…”

Section: Hulcmentioning

confidence: 99%

“…Long non-coding RNAs (lncRNAs) are a subgroup of non-coding RNA (ncRNAs) transcripts, which are greater than 200 nucleotides in length, with little or no protein-coding potential [1,2]. While lncRNAs are emerging as important contributors to the biological processes underlying the pathophysiology of various human diseases, including inflammation and neoplasia [3], the involvement of these molecules in chronic liver diseases, such as viral hepatitis and nonalcoholic fatty liver disease (NAFLD), has only been considered in scientific research [3].…”

Section: Introductionmentioning

confidence: 99%

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LncRNAs Act as a Link between Chronic Liver Disease and Hepatocellular Carcinoma

Kim

Park

Lee

2020

IJMS

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Long non-coding RNAs (lncRNAs) are emerging as important contributors to the biological processes underlying the pathophysiology of various human diseases, including hepatocellular carcinoma (HCC). However, the involvement of these molecules in chronic liver diseases, such as nonalcoholic fatty liver disease (NAFLD) and viral hepatitis, has only recently been considered in scientific research. While extensive studies on the pathogenesis of the development of HCC from hepatic fibrosis have been conducted, their regulatory molecular mechanisms are still only partially understood. The underlying mechanisms related to lncRNAs leading to HCC from chronic liver diseases and cirrhosis have not yet been entirely elucidated. Therefore, elucidating the functional roles of lncRNAs in chronic liver disease and HCC can contribute to a better understanding of the molecular mechanisms, and may help in developing novel diagnostic biomarkers and therapeutic targets for HCC, as well as in preventing the progression of chronic liver disease to HCC. Here, we comprehensively review and briefly summarize some lncRNAs that participate in both hepatic fibrosis and HCC.

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Section: Lncrnas Associated With Both Chronic Liver Disease and Hccmentioning

confidence: 88%

Section: Lncrnas Associated With Both Chronic Liver Disease and Hccmentioning

confidence: 99%

Section: Lncrnas Associated With Both Chronic Liver Disease and Hccmentioning

confidence: 99%

“…The levels of HULC were positively correlated with HBV X protein (HBx) in HCC patients [1]. The activation of HULC promotes HBx-mediated cell proliferation by inducing p18 [46].…”

Section: Hulcmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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LncRNAs Act as a Link between Chronic Liver Disease and Hepatocellular Carcinoma

Kim

Park

Lee

2020

IJMS

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LncRNA NEAT1 in the pathogenesis of liver‐related diseases

Saleh,

Alkhafaji,

Mohammed

et al. 2024

Cell Biochemistry & Function

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Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long noncoding RNA (lncRNA) that is widely expressed in a variety of mammalian cell types. Altered expression levels of the lncRNA NEAT1 have been reported in liver‐related disorders including cancer, fatty liver disease, liver fibrosis, viral hepatitis, and hepatic ischemia. lncRNA NEAT1 mostly acts as a competing endogenous RNA (ceRNA) to sponge various miRNAs (miRs) to regulate different functions. In regard to hepatic cancers, the elevated expression of NEAT1 has been reported to have a relation with the proliferation, migration, angiogenesis, apoptosis, as well as epithelial‐mesenchymal transition (EMT) of cancer cells. Furthermore, NEAT1 upregulation has contributed to the pathogenesis of other liver diseases such as fibrosis. In this review, we summarize and discuss the molecular mechanisms by which NEAT1 contributes to liver‐related disorders including acute liver failure, nonalcoholic fatty liver disease (NAFLD), liver fibrosis, and liver carcinoma, providing novel insights and introducing NEAT1 as a potential therapeutic target in these diseases.

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Role of long non‐coding RNAs in cholangiocarcinoma: A systematic review and meta‐analysis

Shobeiri,

Arabzadeh Bahri,

Khadembashiri

et al. 2024

Cancer Reports

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BackgroundCholangiocarcinoma (CCA), as a rare malignancy of the biliary tree, has a poor prognosis most of the time. CCA is highly epigenetically regulated and several long non‐coding RNAs (lncRNA) have been investigated to have a diagnostic and prognostic role in CCA. The current study aimed to assess the studies finding relevant lncRNAs in CCA systematically.MethodsInternational databases, including PubMed, Cochrane Library, and Embase, were comprehensively searched in order to identify studies investigating any lncRNA in CCA. After screening by title/abstract and full‐text, necessary data were extracted. Random‐effect meta‐analysis was performed for pooling the areas under the curve (AUCs), specificity, and sensitivity of lncRNAs for the diagnosis of CCA.ResultsA total of 33 studies were chosen to be included in the final analysis, comprised of 2677 patients. Meta‐analysis of AUCs for evaluation of CCA resulted in pooled AUC of 0.79 (95% CI: 0.75–0.82; I2 = 69.11, p < .01). Additionally, overall sensitivity of 0.80 (95% CI 0.75–0.84) and specificity of 0.77 (95% CI: 0.68–0.84) were observed. Measurement of lncRANs in the assessment of CCA also improved overall survival significantly (effect size 1.61, 95% CI: 1.39–1.82). A similar result was found for progression‐free survival (effect size 1.57, 95% CI: 1.20–1.93).ConclusionBased on our findings, lncRNAs showed promising results as biomarkers in the diagnosis of CCA since they had acceptable sensitivity and specificity, in addition to the fact that improved survival in this poor prognosis cancer. Further studies might be needed to address this issue and find the best clinically useful lncRNA.

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Role of non-coding RNAs in liver disease progression to hepatocellular carcinoma

Cited by 49 publications

References 164 publications

LncRNAs Act as a Link between Chronic Liver Disease and Hepatocellular Carcinoma

LncRNAs Act as a Link between Chronic Liver Disease and Hepatocellular Carcinoma

LncRNA NEAT1 in the pathogenesis of liver‐related diseases

Role of long non‐coding RNAs in cholangiocarcinoma: A systematic review and meta‐analysis

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