Role of nitric oxide synthases polymorphism in the development of comorbidity of bronchial asthma and hypertension

Uryasev, Oleg; Shakhanov, A. V.

doi:10.17750/kmj2017-226

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…Among neuropeptides, we can identify those with anti inflammatory (vasointestinal peptide (VIP)) and proinflam matory (substance P) effects [1,5,6]. VIP is produced by neurons, endocrine and immune cells and is present in most organs, including the central nervous system, heart, lungs, thyroid gland, kidneys, urinary and gastrointestinal tract, genital organs and immune system [2,7]. VIP suppresses the expression of other inflammatory mediators [5].…”

Section: Introductionmentioning

confidence: 99%

Neurotransmitter serum levels in children with recurrent upper respiratory tract infections

Ovcharenko

Sheludko

Vertehel

et al. 2021

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Background. Schoolchildren are prone to frequent respiratory tract diseases. In the structure of general morbidity, this pathology ranks first. Its prevalence is more than 60 %, which leads to frequent school absenteeism, lack of active games and outdoor walks. So, there is an increase in the amount of time that a child spent on means of mass electronic communication and electronic games, resulting in high affection and addiction, forming hypodynamia, which in aggregate has a negative impact on the regulatory systems functioning. Recurrent upper respiratory tract infections (URTI) contribute to the strain of neuro-endocrine-immune regulation, causing an imbalance of neuropeptides-mediators of neurogenic inflammation. The purpose of this work is to study the neurogenic inflammation parameters in schoolchildren with functional disorders of the cardiovascular system and recurrent respiratory tract diseases. Materials and methods. We surveyed 130 children with URTI aged 6 to 9 years in the somatic well-being period. The analysis of the contents of vasoactive intestinal peptide (VIP), substance P and final stable metabolites of nitric oxide (FSM NO) in serum was carried out. An increase in substance P level in children with recurrent URTI was found, which had statistically significant differences with the healthy children indices (p < 0.05). Results. It has been found that high concentration of substance P increases the risk of recurrent URTI. It has been proved that in children with recurrent URTI due to increased FSM NO serum content that has a pro-inflammatory orientation, there is an increased neurogenic inflammation activity. It was found that the reliable reduction in the content of VIP as an anti-inflammatory transmitter in children with recurrent URTI can not suppress the activity of neurogenic inflammation, resulting in its excessive stimulation. Conclusions. Children with recurrent URTI in the somatic well-being period have increased serum levels of substance Р and FSM NO. In the somatic well-being period in schoolchildren with recurrent URTI, a decrease in the concentration of antiinflammatory neuropeptide VIP is observed.

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Section: Introductionmentioning

confidence: 99%

Neurotransmitter serum levels in children with recurrent upper respiratory tract infections

Ovcharenko

Sheludko

Vertehel

et al. 2021

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“…For positional mapping, an analysis is made of the linkage of the disease with the chromosomal position. Chromosomal regions carrying BA susceptibility genes include 5q31.1-33, 6p12-21.2, 11q12-13, 12q14-24.1, 13q12-22, 14q11-12, and 16p12.1-11.2 и Xq28/Yq12 [14].…”

Section: Introductionmentioning

confidence: 99%

Bronchial Asthma: Genetic Factors Contributing to its Pathogenesis

Krynytska

Mykolenko

Smachylo

et al. 2021

Open Access Maced J Med Sci

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Researching bronchial asthma (BA)-linked gene polymorphisms can help to clarify heterogeneity of the disease and estimate its severity, which, in turn, will aid in developing an appropriate treatment corresponding to the patient’s unique asthma pathogenesis. The aim of presented review is to analyze the published data on the genetic preconditions of BA and the possible role of different genes polymorphisms in its pathogenesis. We have found that despite the fact that numerous genes are involved in the pathogenesis of BA and their polymorphisms are associated with increased risks for BA, it is important to understand that a combination of factors, both genetic and environmental, triggers BA development and determines its progression. On the other hand, the identification of BA susceptibility genes contributing to asthma pathogenesis and treatment response is the first step toward the development of personalized medicine.

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“…Нам представляется, что создание такой системы оценки регуляции АД от интегративного уровня до периферического (эндотелиально-микроциркуляторного) позволит разработать новые методологические подходы к пониманию патогенеза и совершенствованию лечения гипертонической болезни (ГБ). В данное время успешно развиваются представления о местных гуморальных механизмах регуляции АД, и успехи на этом пути весьма существенны [2]. В поддержании величины АД известна и достаточно хорошо освещена роль почек и сердца [3,4].…”

Section: Introductionunclassified

Hierarchical organization of the blood pressure regulation system in the human body

Покровский¹,

Елисеева²,

Самородская³

2021

Zhurnal «Patologicheskaia Fiziologiia I Eksperimental`naia Terapiia»

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Цель исследования - создание на основе анализа нарушений механизмов системы регуляции артериального давления (АД) нового методологического подхода в определении эффективности антигипертензивной терапии у пациентов с гипертонической болезнью. Методика. В исследование включены данные 277 пациентов (136 мужчин, 141 женщина) с гипертонической болезнью II стадии 1-2 степени, риск II, III. Возраст пациентов 58,6±6,4 лет, давность заболевания 7,2±1,4 лет. В группу контроля вошли 57 практически здоровых лиц (25 женщин, 32 мужчины) в возрасте 52,1±4,4 года. После скрининга и получения письменного информированного согласия в виде монотерапии назначены: небиволол, лизиноприл, лозартан, индапамид, амлодипин, и нефиксированная комбинация лизиноприла и индапамида. Изучены изменения показателей АД на выделенных уровнях системы регуляции АД после 6 мес терапии. Результаты. Оценка эффективности применяемой терапии показала, что при стабилизации артериального давления у пациентов всех 6 групп на должном уровне существенные различия выявлены на интегративном уровне регуляции. При применении амлодипина, лозартана, лизиноприла, а также комбинации лизиноприла и индапамида регуляторно-адаптивные возможности организма улучшились, при лечении индапамидом - не изменились, при применении небиволола снизились. Предложена оригинальная классификация уровней регуляции (контроля) артериального давления у человека, основанная на общебиологическом принципе иерархической организации регуляции вегетативных функций. Выделены уровни: интегративный, вегетативного обеспечения (осуществляемый автономной нервной системой), органный, периферический (эндотелиально-микроциркуляторный). Заключение. Количественная оценка на интегративном уровне является универсальным показателем эффективности лечения, что открывает возможность создания методологического подхода, основанного на оценке влияния терапевтических воздействий не только на орган- или функцию-мишень, но и на состояние организма как целостной системы. Aim. To create a new methodological approach for determining the effectiveness of antihypertensive therapy in patients with arterial hypertension based on the analysis of violation of mechanisms in the blood pressure (BP) regulation system. Methods. This study included 277 patients (136 males, 141 females) with stage II, grade 1-2 hypertension, risk II, III, aged 58.6±6.4 yrs, with disease duration 7.2±1.4 yrs. The control group included 57 essentially healthy individuals (25 females, 32 males) aged 52.1±4.4 yrs. After screening and obtaining written informed consent, the following monotherapy was prescribed: nebivolol, lisinopril, losartan, indapamide, and amlodipine, plus an unfixed combination of lisinopril and indapamide. Changes in BP indexes at the predetermined levels of the BP regulation system were studied after 6 mos. of treatment. Results. Evaluation of the therapy effectiveness showed that, when BP was stabilized in all six groups at proper values, significant differences were revealed at the integrative regulatory level. When patients were treated with amlodipine, losartan, lisinopril, as well as a combination of lisinopril and indapamide, the regulatory and adaptive capabilities of the body improved. When treated with indapamide, these capabilities were unchanged, and when treated with nebivolol, these capabilities decreased. A new classification of the regulatory levels of BP control in humans is proposed. This classification is based on the general biological principle of hierarchical organization for the regulation of autonomic functions. The following levels are distinguished: integrative, autonomic support, i.e., carried out by the autonomic nervous system, organ, and peripheral, i.e., endothelial-microcirculatory. Conclusion. Quantitative assessment at the integrative level is a universal indicator of the treatment effectiveness. It makes it possible to create a methodological approach to determine possible effectiveness of treatment based on the assessed impact not only on the target organ or function, but also on the status of the body as a whole system.

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Role of nitric oxide synthases polymorphism in the development of comorbidity of bronchial asthma and hypertension

Cited by 4 publications

References 9 publications

Neurotransmitter serum levels in children with recurrent upper respiratory tract infections

Neurotransmitter serum levels in children with recurrent upper respiratory tract infections

Bronchial Asthma: Genetic Factors Contributing to its Pathogenesis

Hierarchical organization of the blood pressure regulation system in the human body

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