Role of Nitric Oxide Production and Matrix Protease Activity in Cruciate Ligament Degeneration

Spreng, David

doi:10.1002/9781118786796.ch10

Cited by 1 publication

(1 citation statement)

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“…NO was chosen for its role in the regulation of vascular tone and as an endogenous vasodilator [ 49 ], as well as for its critical role in the production and reduction of nociception and pain [ 50 ]. However, in this study, the authors found no variations in its synovial concentration over time or between treatments, although the values obtained in the study are comparable to those of other authors [ 51 ] who have found substantially higher values than those for healthy animals.…”

Section: Discussionsupporting

confidence: 87%

Effects of Oral Hyaluronic Acid Administration in Dogs Following Tibial Tuberosity Advancement Surgery for Cranial Cruciate Ligament Injury

Aguado

Ramos-Plá

Soler

et al. 2021

Animals

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Hyaluronic acid (HA) intraarticular injection is used in the management of osteoarthritis in veterinary medicine. However, HA oral administration is less common given the scarce currently available scientific evidence. This study was aimed at evaluating the effects of oral HA administration on synovial fluid concentrations of several selected biomarkers in dogs with cranial cruciate ligament (CCL) injury operated on using the tibial tuberosity advancement (TTA) technique. Fifty-five dogs were included in this prospective, randomized, double-blind, clinical study; they were randomly assigned to receive either a placebo (group A; n = 25) or HA (group B; n = 30) orally for 10 weeks. Synovial fluid samples were obtained before surgery, and at 10 weeks postoperatively to measure concentrations of HA, haptoglobin, nitric oxide, and paraoxonase-1. After 10 weeks, group HA showed a significant increase in HA concentration (p = 0.0016) and a significant decrease in PON-1 concentration (p = 0.011) compared to baseline. In conclusion, post-op oral HA administration in canine patients with CCL injury leads to improvements in osteoarthritis biomarkers, namely higher synovial fluid HA concentrations and reduced synovial fluid paraoxonase-1 concentrations. These findings support the bioavailability of orally-administered HA and its usefulness in improving biomarkers of osteoarthritis.

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Section: Discussionsupporting

confidence: 87%