Role of nitric oxide on purinergic signalling in the cochlea

Harada, Narinobu

doi:10.1007/s11302-010-9186-7

Cited by 8 publications

(7 citation statements)

References 131 publications

(150 reference statements)

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“…A cross talk between NO and ATP is suggested in the auditory signal transduction. 21 Our study showed that the noise-induced NO decrease may therefore affect hearing negatively. We need to prove this finding by checking NOS expression in these subjects in the future planning studies.…”

Section: Discussionmentioning

confidence: 59%

The Effects of Noise on Oxidative and Antioxidative Balance in Human Erythrocytes

Pınar¹,

Atlı²,

Alaçam³

et al. 2011

UHOD

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Reactive oxygen and nitrogen species have been implicated in the pathogenesis of noise-induced hearing loss. In this case-control study, we investigated the oxidative and antioxidative status of erythrocytes from workers in noisy workplace. Blood samples of 127 workers in noisy workplace (WNW) and 117 workers in non-noisy workplace (WNNW) from the same company were taken into tubes with potassium EDTA as anticoagulant in order to obtain hemolysate. Total superoxide dismutase (SOD) and catalase (CAT) activities as the enzymes of antioxidative defense mechanism in the erythrocytes together with malondialdehyde (MDA) as the lipid peroxidation index and total nitric oxide (NO) as an index for nitrogen species analyses were performed by spectrophotometric methods. SOD activity was found to be 450.0±106.4 U/g Hb in WNW and 443.1±83.1 U/g Hb in WNNW. The difference between two groups were not statistically significant (p= 0.582). CAT activity was found to be 426.0±98.0 k/g Hb in WNW and 432.6±109.0 k/g Hb in WNNW showing statistically insignificant difference (p= 0.621). MDA levels in erythrocytes from WNW was significantly higher than WNNW (39.28±10.22 nmol/g Hb and 32.51±10.73 nmol/g Hb, respectively and p= 0.0001). On the other hand, NO levels were found to be significantly reduced in WNW (0.275±0.187 µmol/g Hb) compared to WNNW (0.382±0.284 µmol/g Hb) (p= 0.001). When we analyzed the hematological parameters, all the cell counts increased in WNW except monocytes and platelets compared to WNNW (p= 0.0001). Related to this changes, hemoglobin, MCHC, and hematocrit also increased in WNW (p= 0.0001). The oxidative stress, which is possibly propagated by the physical environment, seems to have an important pathophysiological role in hearing loss and lipid peroxidative cellular changes in all of the workers who work in noisy occupations.Key words: Noise, Worker, Oxidative stress, Superoxide dismutase, Catalase, Malondialdehyde, Nitric oxide ÖZET Gürültünün ‹nsan Eritrositlerindeki Oksidan ve Antioksidan Dengeye EtkileriReaktif oksijen ve nitrojen türleri, yüksek ses kaynakl› duyma kay›plar›nda önemli bir patolojik faktör olarak kabul görmekte-dir. Bu vaka kontrollü çal›flmam›zda yüksek sesli ortamlarda çal›flan iflçilerin eritrositlerinde oksidan ve antioksidan dengeyi araflt›rd›k. Yüksek sesli ortamda çal›flan (YSOÇ) 127 iflçi ile normal ortamda çal›flan (NOÇ) 117 iflçinin kanlar› hemolizat elde etmek üzere içinde antikoagulan olarak potasyum EDTA bulunan tüplere al›nd›.

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Section: Discussionmentioning

confidence: 59%

The Effects of Noise on Oxidative and Antioxidative Balance in Human Erythrocytes

Pınar¹,

Atlı²,

Alaçam³

et al. 2011

UHOD

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“…Additional examples of ATP-elicited production and release of NO include the cochlea [215] or the vascular system, where NO released from endothelium induces smooth muscle relaxation [216].…”

Section: Nitric Oxide Signalingmentioning

confidence: 99%

Extracellular ATP and other nucleotides—ubiquitous triggers of intercellular messenger release

Zimmermann

2015

Purinergic Signalling

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Extracellular nucleotides, and ATP in particular, are cellular signal substances involved in the control of numerous (patho)physiological mechanisms. They provoke nucleotide receptor-mediated mechanisms in select target cells. But nucleotides can considerably expand their range of action. They function as primary messengers in intercellular communication by stimulating the release of other extracellular messenger substances. These in turn activate additional cellular mechanisms through their own receptors. While this applies also to other extracellular messengers, its omnipresence in the vertebrate organism is an outstanding feature of nucleotide signaling. Intercellular messenger substances released by nucleotides include neurotransmitters, hormones, growth factors, a considerable variety of other proteins including enzymes, numerous cytokines, lipid mediators, nitric oxide, and reactive oxygen species. Moreover, nucleotides activate or co-activate growth factor receptors. In the case of hormone release, the initially paracrine or autocrine nucleotide-mediated signal spreads through to the entire organism. The examples highlighted in this commentary suggest that acting as ubiquitous triggers of intercellular messenger release is one of the major functional roles of extracellular nucleotides. While initiation of messenger release by nucleotides has been unraveled in many contexts, it may have been overlooked in others. It can be anticipated that additional nucleotide-driven messenger functions will be uncovered with relevance for both understanding physiology and development of therapy.

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“…Prior to hearing onset, spontaneous Ca 2+ APs of IHCs are the result of ATP that is released from the organ of Kölliker and that drives small voltage input in IHCs after birth (Tritsch and Bergles 2010 ; Tritsch et al 2007 ; for a review, see Wang and Bergles 2014 ). ATP possibly activates IHCs through ligand-gated ionotropic P2X receptors or G-protein-coupled metabotropic P2Y receptors, both of which have been reported to induce increases of the intracellular Ca 2+ concentration ([Ca 2+ ] i ; Harada 2010 ). During the period of spontaneous Ca 2+ APs, the synaptic machinery of IHCs progressively evolves from multiple spherical bodies, typical of immature hair cells (Fig.…”

Section: Critical Maturation Steps Of Ihc Synapse Before Hearing Onsementioning

confidence: 99%

Specific synaptopathies diversify brain responses and hearing disorders: you lose the gain from early life

Knipper

Panford-Walsh²,

Singer

et al. 2015

Cell Tissue Res

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Before hearing onset, inner hair cell (IHC) maturation proceeds under the influence of spontaneous Ca2+ action potentials (APs). The temporal signature of the IHC Ca2+ AP is modified through an efferent cholinergic feedback from the medial olivocochlear bundle (MOC) and drives the IHC pre- and post-synapse phenotype towards low spontaneous (spike) rate (SR), high-threshold characteristics. With sensory experience, the IHC pre- and post-synapse phenotype matures towards the instruction of low-SR, high-threshold and of high-SR, low-threshold auditory fiber characteristics. Corticosteroid feedback together with local brain-derived nerve growth factor (BDNF) and catecholaminergic neurotransmitters (dopamine) might be essential for this developmental step. In this review, we address the question of whether the control of low-SR and high-SR fiber characteristics is linked to various degrees of vulnerability of auditory fibers in the mature system. In particular, we examine several IHC synaptopathies in the context of various hearing disorders and exemplified shortfalls before and after hearing onset.

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Role of nitric oxide on purinergic signalling in the cochlea

Cited by 8 publications

References 131 publications

The Effects of Noise on Oxidative and Antioxidative Balance in Human Erythrocytes

The Effects of Noise on Oxidative and Antioxidative Balance in Human Erythrocytes

Extracellular ATP and other nucleotides—ubiquitous triggers of intercellular messenger release

Specific synaptopathies diversify brain responses and hearing disorders: you lose the gain from early life

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