1995
DOI: 10.1016/0014-2999(94)00691-y
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Role of nitric oxide in hyporeactivity to noradrenaline of isolated aortic rings in portal hypertensive rats

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Cited by 33 publications
(15 citation statements)
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“…In rat aorta, there are reports that nitric oxide synthase inhibitors failed to restore responses to normal in portal hypertensive animals [26] or that nitric oxide synthase inhibitors restored responses to normal in portal hypertensive [27] and cirrhotic animals [28]. Removal of the endothelium failed to restore responses in portal hypertensive [29] and cirrhotic animals [28], but was found in another study to restore responses in aorta from cirrhotic animals [30].…”
Section: Strain Days Agonistmentioning
confidence: 83%
“…In rat aorta, there are reports that nitric oxide synthase inhibitors failed to restore responses to normal in portal hypertensive animals [26] or that nitric oxide synthase inhibitors restored responses to normal in portal hypertensive [27] and cirrhotic animals [28]. Removal of the endothelium failed to restore responses in portal hypertensive [29] and cirrhotic animals [28], but was found in another study to restore responses in aorta from cirrhotic animals [30].…”
Section: Strain Days Agonistmentioning
confidence: 83%
“…Different studies give evidence that either NOS (36,37) or iNOS (6,38) or even both enzymes (39) are responsible for excessive NO release. The crucial question arises: Which factor(s) stimulates NOS enzymes already at an early stage of cirrhosis?…”
Section: Discussionmentioning
confidence: 99%
“…There is evidence that nitric oxide plays a major role in vascular hyporeactivity (6,(8)(9)(10) and the hyperdynamic circulatory state (11)(12)(13)(14), since these effects can be at least partly abolished by inhibitors of nitric oxide synthesis.…”
mentioning
confidence: 99%
“…In rat aorta, there are reports that nitric oxide synthase inhibitors failed to restore responses to normal in portal hypertensive animals [26] or that nitric oxide synthase inhibitors restored responses to normal in portal hypertensive [27] and cirrhotic animals [28]. Removal of the endothelium failed to restore responses in portal hypertensive [29] and cirrhotic animals [28], but was found in another study to restore responses in aorta from cirrhotic animals [30].…”
Section: Strain Days Agonistmentioning
confidence: 96%