Role of nitric oxide in the control of coronary resistance in teleosts

Agnisola, Claudio

doi:10.1016/j.cbpb.2005.05.051

Cited by 25 publications

(9 citation statements)

References 47 publications

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“…Moreover, GSH-PX is worked on protection of membranes against the oxidative degradation of lipids (Ritola et al, 2002 ). Nitric oxide (NO) is one of the smallest a bioactive cellular component (Gong et al, 2004 ), which involves several physiological functions such as protecting from oxidative and hypoxia stress, homeostasis, cytotoxicity (Agnisola, 2005 ).…”

Section: Introductionmentioning

confidence: 99%

Transport Stress Changes Blood Biochemistry, Antioxidant Defense System, and Hepatic HSPs mRNA Expressions of Channel Catfish Ictalurus punctatus

Refaey

2018

Front. Physiol.

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Transport procedures usually cause fish stress. The purpose of this study was to investigate the effect of transport stress on blood biochemical profiles, oxidative stress biomarkers, and hepatic heat shock proteins (HSPs) of channel catfish (Ictalurus punctatus). Fish (body weight 55.57 ± 5.13 g) were randomly distributed to two groups, the control, and the treatment. The control group was kept under the normal culture conditions. The treatment group was exposed to the process of transport (3.5 h). Fish samples were collected before transport, after packing and at 0, 1, 6, 24, 72, and 168 h after transport, respectively. Transport caused a significant increase in the serum concentrations of cortisol, glucose, total cholesterol, and triglyceride, as well as, the activity of aspartate aminotransferase at 0 and 1 h after transport compared with non-transported fish and the basal level. Blood total protein content significantly declined in the transported fish. Total antioxidant capacity (T-AOC), malonaldehyde content, and the activities of both glutathione peroxidase and catalase significantly increased in fish within 6 h after transport. The transported fish exhibited a significant higher level in either the concentration of nitric oxide or the mRNA expressions of both hepatic HSP70 and HSP90. It is concluded that transport triggers stress response of I. punctatus, leading to the obvious change in antioxidant capacity. I. punctatus need to be more care after transport to recover from transport stress.

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Section: Introductionmentioning

confidence: 99%

Transport Stress Changes Blood Biochemistry, Antioxidant Defense System, and Hepatic HSPs mRNA Expressions of Channel Catfish Ictalurus punctatus

Refaey

2018

Front. Physiol.

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“…Teleost fish express NOS enzymes, and albeit conflicting results are available in the literature, it appears that the functional roles of NO in teleost fish and mammals are comparable (Tota et al, 2005;Agnisola, 2005;Pelster, 2007;Olson and Donald, 2009). Similarly, nitrite may function as a NO donor under hypoxic conditions in fish, and the importance could exceed that in mammals, given that many fish species naturally experience fluctuating or chronic low ambient P O2 values (Jensen, 2009a).…”

Section: Introductionmentioning

confidence: 99%

Nitric oxide metabolites in goldfish under normoxic and hypoxic conditions

Hansen

Frank

2010

Journal of Experimental Biology

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SUMMARYNitric oxide (NO), produced by nitric oxide synthases (NOS enzymes), regulates multiple physiological functions in animals. NO exerts its effects by binding to iron (Fe) of heme groups (exemplified by the activation of soluble guanylyl cyclase) and by Snitrosylation of proteins -and it is metabolized to nitrite and nitrate. Nitrite is used as a marker for NOS activity but it is also a NO donor that can be activated by various cellular proteins under hypoxic conditions. Here, we report the first systematic study of NO metabolites (nitrite, nitrate, S-nitroso, N-nitroso and Fe-nitrosyl compounds) in multiple tissues of a non-mammalian vertebrate (goldfish) under normoxic and hypoxic conditions. NO metabolites were measured in blood (plasma and red cells) and heart, brain, gill, liver, kidney and skeletal muscle, using highly sensitive reductive chemiluminescence. The severity of the chosen hypoxia levels was assessed from metabolic and respiratory variables. In normoxic goldfish, the concentrations of NO metabolites in plasma and tissues were comparable with values reported in mammals, indicative of similar NOS activity. Exposure to hypoxia [at P O2 (partial pressure of O 2 ) values close to and below the critical P O2 ] for two days caused large decreases in plasma nitrite and nitrate, which suggests reduced NOS activity and increased nitrite/nitrate utilization or loss. Tissue NO metabolites were largely maintained at their tissue-specific values under hypoxia, pointing at nitrite transfer from extracellular to intracellular compartments and cellular NO generation from nitrite. The data highlights the preference of goldfish to defend intracellular NO homeostasis during hypoxia.

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“…These results suggest that the reduced capacity of trout chromaffin cells to secrete catecholamines after repeated hypoxia reflects an increase in the expression of nNOS and a subsequent increase in NO production during chromaffin-cell activation. Hypoxia, nitric oxide and catecholamine secretion Nitric oxide (NO) is another such neurotransmitter (Furchgott, 1999) that, in addition to being implicated in cardiovascular control (Donald and Broughton, 2005;Tota et al, 2005;Agnisola, 2005;Eddy, 2005) and osmoregulation (Evans et al, 2004;Ebbesson et al, 2005), also plays an important role in the regulation of catecholamine secretion in fish (McNeill and Perry, 2005). As in mammals (Schwarz et al, 1998;Nagayama et al, 1998;Barnes et al, 2001;Kolo et al, 2004), NO profoundly inhibits agonist-evoked catecholamine secretion in rainbow trout (McNeill and Perry, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…In mammals, hypoxia is known to increase NO production in various tissues including skeletal muscle (Javeshghani et al, 2000), brain (Prabhakar et al, 1996) and lung (Vaughan et al, 2003). Although less well-studied, there is emerging evidence that hypoxia also evokes NO production in fish (McNeill and Perry, 2005;Agnisola, 2005;Swenson et al, 2005). Thus, although plasma catecholamine and NO levels presumably increase concurrently during hypoxia in rainbow trout, the consequences of NO production on catecholamine secretion during hypoxia in vivo have not been investigated.…”

Section: Introductionmentioning

confidence: 99%

The interactive effects of hypoxia and nitric oxide on catecholamine secretion in rainbow trout (Oncorhynchus mykiss)

McNeill

Perry

2006

Journal of Experimental Biology

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SUMMARY Experiments were performed to test the hypothesis that exposure of rainbow trout to repetitive hypoxia would result in a decreased capacity of chromaffin cells to secrete catecholamines owing to increased production of nitric oxide(NO), a potent inhibitor of catecholamine secretion. A partial sequence of trout neuronal nitric oxide synthase (nNOS) was cloned and its mRNA was found to be present in the posterior cardinal vein (PCV), the predominant site of chromaffin cells in trout. Using heterologous antibodies, nNOS and endothelial NOS (eNOS) were localized in close proximity to the chromaffin cells of the PCV. Exposure of trout to acute hypoxia (5.33 kPa for 30 min) in vivoresulted in significant increases in plasma catecholamine and NO levels. However, after 4 days of twice-daily exposures to hypoxia, the elevation of plasma catecholamine levels during hypoxia was markedly reduced. Associated with the reduction in plasma catecholamine levels during acute hypoxia was a marked increase in basal and hypoxia-evoked circulating levels of NO that became apparent after 2-4 days of repetitive hypoxia. The capacity of the chromaffin cells of the hypoxia-exposed fish to secrete catecholamine was assessed by electrical stimulation of an in situ saline-perfused PCV preparation. Compared with control (normoxic) fish, the PCV preparations derived from fish exposed to repeated hypoxia displayed a significant reduction in electrically evoked catecholamine secretion that was concomitant with a marked increased in NO production. This additional rise in NO secretion in preparations derived from hypoxic fish was prevented after adding NOS inhibitors to the perfusate; concomitantly, the reduction in catecholamine secretion was prevented. The increased production of NO during hypoxia in vivo and during electrical stimulation in situ was consistent with significant elevations of nNOS mRNA and protein; eNOS protein was unaffected. These results suggest that the reduced capacity of trout chromaffin cells to secrete catecholamines after repeated hypoxia reflects an increase in the expression of nNOS and a subsequent increase in NO production during chromaffin-cell activation.

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Role of nitric oxide in the control of coronary resistance in teleosts

Cited by 25 publications

References 47 publications

Transport Stress Changes Blood Biochemistry, Antioxidant Defense System, and Hepatic HSPs mRNA Expressions of Channel Catfish Ictalurus punctatus

Transport Stress Changes Blood Biochemistry, Antioxidant Defense System, and Hepatic HSPs mRNA Expressions of Channel Catfish Ictalurus punctatus

Nitric oxide metabolites in goldfish under normoxic and hypoxic conditions

The interactive effects of hypoxia and nitric oxide on catecholamine secretion in rainbow trout (Oncorhynchus mykiss)

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