Role of nitric oxide in orthodontic tooth movement (Review)

Yan, Tong; Xie, Yufeng; He, Hongwen; Fan, Wenguo; Huang, Fang

doi:10.3892/ijmm.2021.5001

Cited by 18 publications

(22 citation statements)

References 215 publications

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“…The expression of TRAF-6 is also dependent on i-NOS activity and positively correlated with the levels of NO thus, having its role in osteoclast activation (Jianbo et al, 2021). Conversely, other reports proposed that NO inhibits bone resorption by inhibiting leukocyte migration and increasing OPG levels (Yan et al, 2021). Silva et al also observed that in i-NOS knockout mice the expression of RANK was up-regulated while that of OPG was decreased thus the higher NO levels may be bene cial in reducing the RC progression towards periapical bone.…”

Section: Discussionmentioning

confidence: 95%

Hazardous Impact of Prophetic Variables in The Development of Radicular Cyst and Associated Periapical Osteo-Invasion

Fareed,

Ahmad,

Iqbal

et al. 2024

Preprint

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Background: The long-standing pulpitis may result in apical periodontitis, which, if left untreated, will ultimately develop into a periapical cyst. Our study aimed to evaluate the hazardous impact of prophetic variables on the development of radicular cysts and associated periapical osteo-invasion. Methodology: One hundred patients with radicular cysts and 100 samples of individuals with normal pulp were selected. For the analytical assessment, periapical tissue samples were obtained from patients experiencing periapical surgery. Tissue homogenate was prepared by using a Potter-Elvehjem homogenizer. The levels of antioxidants and pro-oxidants were assessed by their respective protocols. The anti-inflammatory status, levels of matrix metalloproteinases (MMPs), and bone remodeling biomarkers were determined by designated ELISA kits. Results: Increased levels of pro-oxidants and inflammatory agents while a diminished quantity of antioxidants were observed in the patients with radicular cysts. The levels of MMPs and sRANKL levels were raised, whereas OPG levels were reduced, indicating the osteo-invasion process in radicular cyst patients. Conclusions: The underlying mechanisms of progression of the radicular cyst into adjacent peri-apical bone provide interesting relationships among the biomarkers of oxidative stress, pro-inflammatory cytokines, and bone remodeling. Thus, novel therapies based on targeting MMPs through the action of TIMPs and abrogating sRANKL-RANK interactions can play a significant role in preventing radicular cyst proliferation.

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Section: Discussionmentioning

confidence: 95%

Hazardous Impact of Prophetic Variables in The Development of Radicular Cyst and Associated Periapical Osteo-Invasion

Fareed,

Ahmad,

Iqbal

et al. 2024

Preprint

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“…iNOS is strongly associated with bone resorption in compression side of periodontal ligament. The inflammatory process generated on the compression side leads to increased iNOS overexpression and osteoclastogenesis, causing orthodontic movement, 29 but the oxidative stress iNOS-mediated leads to synthesis of ROS in apical region and pulp inflammation. 30,31 Ford et al (2014) 6 showed a gradual increase in the quantification of NO levels in the gingival fluid soon after the application of tooth movement.…”

Section: Discussionmentioning

confidence: 99%

Intense orthodontic force induces the three dental pulp nitric oxide synthase isoforms and leads to orofacial discomfort in rats

Sobrinho

Aguiar

Machado

et al. 2022

Orthod Craniofacial Res

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Objective The objective of this study was to evaluate the role of nitric oxide synthase (NOS) isoforms influence during tooth movement with different forces. Settings and sample population 100 male Wistar rats (n = 10/group) were divided into a Sham group (animals not submitted to device installation nor Induced Toot Movement [ITM]), Negative Control Group (NCG) (animals submitted to device installation but not to ITM) and three experimental groups (F1, F2 and F3) (submitted to ITM with forces of 25, 50 and 100 gF respectively). Materials and methods A daily count of biting and scratching on the vibrissae and the Grimace scale were applied. After 4 (D4) and 11 (D11) days, the molar diastema was measured, and the animals were euthanized for histological (vascular parameters) and immunohistochemistry (iNOS, eNOS and nNOS) in the dental pulp. Results On D4, there was significant movement in the F3 group (P = .001) and on D11 in F1, F2 and F3 (P < .001). The number of bites (P < .001) and scratching (P = .006) was higher in F2‐F3, and F3 had higher Grimace scores (P < .001) and weight loss (P < .001). At D4, there was an increase in pulp ectasia in F2‐F3 (P = .021) and a reduction in the number of vessels in F3 (P = .005). In D4 and D11, there was a significant increase in immunostaining for iNOS and eNOS in F1 (P = .025 and P < .001 respectively) and F2 (P = .007 and P < .001 respectively). At D4, F2 and F3 showed higher immunostaining for nNOS (P = .027). Conclusion Thus, IDM induced inflammatory changes in the dental pulp reflecting in force‐dependent pain/suffering signs.

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“…At present, the role of NO in OTM has been reported. Using the intervention of L-arginine (NO precursor) and L-NMMA (nitric oxide synthase inhibitor), they demonstrated that NO can promote OTM, but the specific mechanism has not been elucidated [ 21 ]. The present study confirmed this conclusion, finding that force-induced endogenous NO can regulate the process of OTM, and then, we explored the role of NO in it.…”

Section: Discussionmentioning

confidence: 99%

Force-Induced Nitric Oxide Promotes Osteogenic Activity during Orthodontic Tooth Movement in Mice

Sun

Lin

et al. 2022

Stem Cells International

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Objectives. The aim of this study was to investigate the effect of nitric oxide (NO) on orthodontic tooth movement and the regulatory effect on bone formation. Design. A mouse orthodontic tooth movement model was established to measure the level of releasing NO. Besides, orthodontic tooth movement distance and the bone formation in the tension side of the orthodontic tooth were also analyzed. In vitro, human periodontal ligament stem cells (hPDLSCs) were cultured under tensile force stimulation. The production of NO and the expression level of nitric oxide synthase (NOS) were detected after mechanical stimulation. Furthermore, the downstream cellular signaling pathway regulated by NO was also explored. Results. The generation of NO steadily increased throughout the orthodontic tooth movement in mice. Orthodontic tooth movement was decreased in the NOS inhibitor group while it was accelerated in the NO precursor group. Force-induced NO promoted the osteogenic differentiation of human hPDLSCs under tensile force stimulation. And force-induced NO in hPDLSCs regulated the PI3K/Akt/β-catenin signal pathway. Conclusion. NO is involved in the regulation of orthodontic tooth movement and promotes bone formation on the tension side of the orthodontic tooth. The PI3K/Akt/β-catenin pathway is one of the downstream cell signal transduction pathways of NO in the orthodontic process.

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Role of nitric oxide in orthodontic tooth movement (Review)

Cited by 18 publications

References 215 publications

Hazardous Impact of Prophetic Variables in The Development of Radicular Cyst and Associated Periapical Osteo-Invasion

Hazardous Impact of Prophetic Variables in The Development of Radicular Cyst and Associated Periapical Osteo-Invasion

Intense orthodontic force induces the three dental pulp nitric oxide synthase isoforms and leads to orofacial discomfort in rats

Force-Induced Nitric Oxide Promotes Osteogenic Activity during Orthodontic Tooth Movement in Mice

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