1999
DOI: 10.1159/000014095
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Role of Nitric Oxide in Cardiovascular Responses to Endotoxemia in Neonatal Lambs

Abstract: To determine whether systemic cardiovascular responses to gram-negative endotoxemia are mediated by nitric oxide, we evaluated time-dependent changes in contractility and hemodynamics in a neonatal sheep model subjected to nitric oxide synthesis inhibition with L-Name (Nω-nitro-L-arginine methyl ester). Four groups were studied: control (C), endotoxin (E), endotoxin L-Name where the nitric oxide synthase inhibitor was given prior to endotoxin (ELN), and a control L-Name group pretreated with L-Name … Show more

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Cited by 2 publications
(1 citation statement)
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“…However, the role of CaSR in LPS-induced myocardial dysfunction has yet not been fully defined. LPS is a major structural component of Gram-negative bacteria, and a key mediator of the body’s response to infection [21, 22]. LPS induces expression of pro-inflammatory cytokines, such as TNF-α and IL-6, which are involved in the pathogenesis of sepsis and are also an early predictors of organ dysfunction [2325].…”
Section: Discussionmentioning
confidence: 99%
“…However, the role of CaSR in LPS-induced myocardial dysfunction has yet not been fully defined. LPS is a major structural component of Gram-negative bacteria, and a key mediator of the body’s response to infection [21, 22]. LPS induces expression of pro-inflammatory cytokines, such as TNF-α and IL-6, which are involved in the pathogenesis of sepsis and are also an early predictors of organ dysfunction [2325].…”
Section: Discussionmentioning
confidence: 99%