Role of neutrophils in the pathogenesis of imiquimod-induced psoriasis-like skin lesions

Kusuba, Nobuhiro; Kitoh, Akihiko; Kabashima, Kenji

doi:10.1016/j.jdermsci.2016.08.224

Cited by 5 publications

(2 citation statements)

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“…However, the development of psoriasis is not only linked to changes in the interaction between lymphocytes and keratinocytes; it also involves the activity of other cells of the immune system. For example, the actions of granulocytes [ 32 , 33 ] can significantly alter the profile of the signaling molecules in the plasma of psoriatic patients [ 34 ]. Such changes do not exclusively affect keratinocytes, and also have consequences for other skin-building cells, including dermal fibroblasts [ 24 , 30 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

Changes in Proteome of Fibroblasts Isolated from Psoriatic Skin Lesions

Gęgotek

Domingues

Wroński³

2020

IJMS

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The dermal fibroblasts are in constant contact with the cells of the immune system and skin epidermis. Therefore, they are essential for the development of lesions in psoriasis. The aim of this study was to assess the changes in the proteomic profile of fibroblasts in the dermis of psoriasis patients, and to discuss the most significant changes and their potential consequences. The proteomic results indicate that fibroblast dysfunction arises from the upregulation of proinflammatory factors and antioxidant proteins, as well as those involved in signal transduction and participating in proteolytic processes. Moreover, downregulated proteins in psoriatic fibroblasts are mainly responsible for the transcription/translation processes, glycolysis/ adenosine triphosphate synthesis and structural molecules. These changes can directly affect intercellular signaling and promote the hyperproliferation of epidermal cells. A better understanding of the metabolic effects of the proteomic changes observed could guide the development of new pharmacotherapies for psoriasis.

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Section: Discussionmentioning

confidence: 99%

Changes in Proteome of Fibroblasts Isolated from Psoriatic Skin Lesions

Gęgotek

Domingues

Wroński³

2020

IJMS

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“…They point to the possibility of using BTK as a therapeutic target in psoriasis because the use of a BTK inhibitor (Ibrutinib) allows a reduction in the level of oxidative stress [ 24 ]. Neutrophils secrete oxidants that have an effect on maintaining inflammation in psoriasis [ 88 ]. The BTK pathway in neutrophils increases the level of oxidative stress in the skin (iNOS induction) [ 89 ].…”

Section: Perspective Markers Of Oxidative Stress In Psmentioning

confidence: 99%

Oxidative Stress as an Important Contributor to the Pathogenesis of Psoriasis

Pleńkowska

Gabig-Cimińska

Mozolewski

2020

IJMS

107

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This review discusses how oxidative stress (OS), an imbalance between oxidants and antioxidants in favor of the oxidants, increased production of reactive oxygen species (ROS)/reactive nitrogen species (RNS), and decreased concentration/activity of antioxidants affect the pathogenesis or cause the enhancement of psoriasis (Ps). Here, we also consider how ROS/RNS-induced stress modulates the activity of transcriptional factors and regulates numerous protein kinase cascades that participate in the regulation of crosstalk between autophagy, apoptosis, and regeneration. Answers to these questions will likely uncover novel strategies for the treatment of Ps. Action in the field will avoid destructive effects of ROS/RNS-mediated OS resulting in cellular dysfunction and cell death. The combination of the fragmentary information on the role of OS can provide evidence to extend the full picture of Ps.

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