volume 192, issue 4, P1745-1752 2014
DOI: 10.4049/jimmunol.1302265
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Anna R. Huppler, Heather R. Conti, Nydiaris Hernández-Santos, Toni Darville, Partha S. Biswas, Sarah L. Gaffen

Abstract: Oropharyngeal candidiasis (OPC), caused by the commensal fungus Candida albicans, is an opportunistic infection associated with infancy, AIDS and IL-17-related primary immunodeficiencies. The Th17-associated cytokines IL-23 and IL-17 are crucial for immunity to OPC, but the mechanisms by which they mediate immunity are poorly defined. IL-17RA-deficient humans and mice are strongly susceptible to OPC, with reduced levels of CXC chemokines and concomitantly impaired neutrophil recruitment to the oral mucosa. Pa…

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