Role of neuropeptide FF in central cardiovascular and neuroendocrine regulation

Jhamandas, Jack H.; Goncharuk, Valeri D.

doi:10.3389/fendo.2013.00008

Cited by 42 publications

(37 citation statements)

References 65 publications

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“…Moreover, Gcglobulin functions as a potent macrophage-activating factor, which greatly enhances phagocytic activity in macrophages (Yamamoto and Homma, 1991). Neuropeptide FF receptors 1 and 2 are membrane proteins activated by neuropeptides NPAF and NPFF, which belong to the RFamide family of peptides (Jhamandas and Goncharuk, 2013). It has been shown that NPFF neuropeptides reduce production of nitric oxide in macrophages and exhibit antiinflammatory activity in a mouse model (Sun et al, 2013).…”

Section: Candidate Genes Within the Targeted Regionmentioning

confidence: 99%

Genome-wide association study using high-density single nucleotide polymorphism arrays and whole-genome sequences for clinical mastitis traits in dairy cattle

Sahana

Guldbrandtsen

Thomsen

et al. 2014

Journal of Dairy Science

100

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Mastitis is a mammary disease that frequently affects dairy cattle. Despite considerable research on the development of effective prevention and treatment strategies, mastitis continues to be a significant issue in bovine veterinary medicine. To identify major genes that affect mastitis in dairy cattle, 6 chromosomal regions on Bos taurus autosome (BTA) 6, 13, 16, 19, and 20 were selected from a genome scan for 9 mastitis phenotypes using imputed high-density single nucleotide polymorphism arrays. Association analyses using sequence-level variants for the 6 targeted regions were carried out to map causal variants using whole-genome sequence data from 3 breeds. The quantitative trait loci (QTL) discovery population comprised 4,992 progeny-tested Holstein bulls, and QTL were confirmed in 4,442 Nordic Red and 1,126 Jersey cattle. The targeted regions were imputed to the sequence level. The highest association signal for clinical mastitis was observed on BTA 6 at 88.97 Mb in Holstein cattle and was confirmed in Nordic Red cattle. The peak association region on BTA 6 contained 2 genes: vitamin D-binding protein precursor (GC) and neuropeptide FF receptor 2 (NPFFR2), which, based on known biological functions, are good candidates for affecting mastitis. However, strong linkage disequilibrium in this region prevented conclusive determination of the causal gene. A different QTL on BTA 6 located at 88.32 Mb in Holstein cattle affected mastitis. In addition, QTL on BTA 13 and 19 were confirmed to segregate in Nordic Red cattle and QTL on BTA 16 and 20 were confirmed in Jersey cattle. Although several candidate genes were identified in these targeted regions, it was not possible to identify a gene or polymorphism as the causal factor for any of these regions.

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Section: Candidate Genes Within the Targeted Regionmentioning

confidence: 99%

Genome-wide association study using high-density single nucleotide polymorphism arrays and whole-genome sequences for clinical mastitis traits in dairy cattle

Sahana

Guldbrandtsen

Thomsen

et al. 2014

Journal of Dairy Science

100

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“…NPFF is known to be involved in morphine tolerance, adipogenesis, and anorectic activity (40–45). In 2000, Tsutsui et al found a new RF-amide peptide, GnIH, in quail brain (5, 46).…”

Section: Evolutionary History Of Npff/npvf Qrfp and Prlhmentioning

confidence: 99%

Does Kisspeptin Belong to the Proposed RF-Amide Peptide Family?

et al. 2014

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Kisspeptin (KISS) plays a key role in regulating reproduction by binding to its receptor, GPR54. Because of the Arg-Phe (RF) sequence at its carboxyl terminus, KISS has been proposed to be a member of the RF-amide peptide family consisting of neuropeptide FF (NPFF), neuropeptide VF (NPVF), pyroglutamylated RF-amide peptide (QRFP), and prolactin-releasing hormone (PRLH). Evolutionary relationships of protein families can be determined through phylogenetic analysis. However, phylogenetic analysis among related peptide families often fails to provide sufficient information because only short mature peptide sequences from full preprohormone sequences are conserved. Considering the concept of the coevolution of peptide ligands and their cognate receptors, evolutionary relationships among related receptor families provide clues to explore relationships between their peptides. Although receptors for NPFF, NPVF, and QRFP are phylogenetically clustered together, receptors for PRLH and KISS are on different branches of the phylogenetic tree. In particular, KISS has been proposed to be a member of the KISS/galanin/spexin family based on synteny analysis and the phylogenetic relationship between their receptors. This article discusses the evolutionary history of the receptors for the proposed RF-amide peptide family and proposes that, from an evolutionary aspect, KISS has emerged from an ancestor, which is distinct from those of the other RF-amide peptides, and so should be classed separately.

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“…14 Additionally, NPFF displays potent effects on regulation of the core temperature, 15 reduction in food intake and changes in arterial blood pressure. 16 The neuropeptide FF receptor family is part of the G protein-coupled receptor superfamily. Several groups cloned two genes encoding two different receptors (NPFFR1 and NPFFR2) and two precursors in several mammalian species.…”

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confidence: 99%