Role of Neurite Outgrowth Inhibitor B Receptor in hepatic steatosis

Chen, Fangzhi; Zhang, Mo; Zhong, Qian; Li, Ming

doi:10.1016/j.acthis.2022.151977

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2023

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“…Scd1, a gene encoding stearoyl-CoA desaturase 1, which is located in the ER, caught our attention because of its high expression in Hepa3 and its indispensable role in the process of liver steatosis [ 40 ]. SCD1 catalyzes the transition from SFAs to MUFAs, including oleic acid and palmitoleic acid [ 41 ], the increase of which causes an increased triglyceride level and accumulation of lipids in hepatocytes, finally leading to hepatocyte steatosis [ [42] , [43] , [44] , [45] ]. Suppression of Scd1 showed inhibition of liver steatosis by regulating lipid metabolism [ 46 , 47 ].…”

Section: Resultsmentioning

confidence: 99%