Role of Nesfatin-1 in the Reproductive Axis of Male Rat

Gao, Xiaoxiao; Zhang, Kaifa; Song, Min; Li, Xiumei; Luo, Lei; Tian, Yuan; Zhang, Yunhai; Li, Yunsheng; Zhang, Xiaorong; Ling, Yinghui; Fang, Fugui; Liu, Ya

doi:10.1038/srep32877

Cited by 50 publications

(58 citation statements)

References 36 publications

(48 reference statements)

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“…Nesfatin‐1 provoked a rise in LH levels in both sexes in rats, when injected ICV (Garcia‐Galiano et al, , ). Central injection of nesfatin‐1 decreased serum testosterone, LH and FSH levels in puberty as well as in adult male rats (Gao et al, ). In addition, the same report has shown as well that nesfatin‐1 could increase the testosterone level in vitro (Gao et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Central injection of nesfatin‐1 decreased serum testosterone, LH and FSH levels in puberty as well as in adult male rats (Gao et al, ). In addition, the same report has shown as well that nesfatin‐1 could increase the testosterone level in vitro (Gao et al, ). Moreover, it was also demonstrated that central injections of anti‐NUCB2 morpholino oligonucleotides during pubertal maturity delayed vaginal opening, decreased ovarian weight and plasma LH titres in female rats in puberty (Garcia‐Galiano et al, ).…”

Section: Discussionmentioning

confidence: 99%

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Contingent role of phoenixin and nesfatin‐1 on secretions of the male reproductive hormones

et al. 2019

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Phoenixin (PNX) and nesfatin‐1 are localised in the hypothalamus and the pituitary gland. Moreover, the most of the PNX‐expressing neurons in the hypothalamus also co‐express nesfatin‐1. These outcomes may suggest that there is an interaction between PNX and nesfatin‐1, at least in terms of neuroendocrine‐mediated regulations. Hence, the study was planned to find out the effects of centrally delivered PNX and nesfatin‐1 on male sex hormones or to show the interactive association of intracerebroventricularly (ICV) injected PNX+nesfatin‐1 combination on the release of male hormones. PNX and nesfatin‐1, single or together, were delivered ICV to different male Wistar Albino rat groups. Both PNX and nesfatin‐1 induced a significant enhancement in plasma FSH, LH and testosterone without inducing any alteration in plasma GnRH in the rats. The central combinatorial treatment of both the neuropeptides produced a more potent rise in male plasma hormone levels than treating with single neuropeptide. In summary, our preliminary data show that centrally delivered PNX and nesfatin‐1 can affect plasma male hormone levels. Moreover, that the combinatorial treatment with both the neuropeptides in male rats leading to a more potent effect on the plasma male hormone levels might suggest that both these neuropeptides act synergistically in terms of regulation of male HPGA.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Contingent role of phoenixin and nesfatin‐1 on secretions of the male reproductive hormones

et al. 2019

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“…administration of nesfatin-1 significantly reduced the expression of GnRH mRNA in the hypothalamus and FSH and LH mRNA in the pituitary (Gao et al 2016), suggesting an inhibitory role of nesfatin-1 on the HPG axis. Matching observations were also made in fish after peripheral administration of nesfatin-1 (Gonzalez et al 2012).…”

Section: Reproductionmentioning

confidence: 99%

Nesfatin-1: functions and physiology of a novel regulatory peptide

Dore

Levata

Lehnert

et al. 2017

Journal of Endocrinology

110

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Nesfatin-1 was identified in 2006 as a potent anorexigenic peptide involved in the regulation of homeostatic feeding. It is processed from the precursor-peptide NEFA/ nucleobindin 2 (NUCB2), which is expressed both in the central nervous system as well as in the periphery, from where it can access the brain via non-saturable transmembrane diffusion. In hypothalamus and brainstem, nesfatin-1 recruits the oxytocin, the melancortin and other systems to relay its anorexigenic properties. NUCB2/nesfatin-1 peptide expression in reward-related areas suggests that nesfatin-1 might also be involved in hedonic feeding. Besides its initially discovered anorexigenic properties, over the last years, other important functions of nesfatin-1 have been discovered, many of them related to energy homeostasis, e.g. energy expenditure and glucose homeostasis. Nesfatin-1 is not only affecting these physiological processes but also the alterations of the metabolic state (e.g. fat mass, glycemic state) have an impact on the synthesis and release of NUCB2 and/or nesfatin-1. Furthermore, nesfatin-1 exerts pleiotropic actions at the level of cardiovascular and digestive systems, as well as plays a role in stress response, behavior, sleep and reproduction. Despite the recent advances in nesfatin-1 research, a putative receptor has not been identified and furthermore potentially distinct functions of nesfatin-1 and its precursor NUCB2 have not been dissected yet. To tackle these open questions will be the major objectives of future research to broaden our knowledge on NUCB2/nesfatin-1.

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“…Nesfatin-1 (an 82-amino acids hormone) has been reported to play a role in the regulation of energy stores via its anorectic actions and has also been implicated in gonadal function. Therefore, nesfatin-1 may play a role in the central control of reproduction [15] . Notwithstanding a role in reproductive behaviors, the widespread distribution of phoenixin in various subnuclei of the hypothalamus suggests that the peptide may mediate a broad range of physiological and/or pathophysiological functions.…”

Section: A Signaling Molecule In the Nervous Systemmentioning

confidence: 99%

Phoenixin: a novel brain-gut-skin peptide with multiple bioactivity

et al. 2018

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In this brief review we summarize the current fndings relative to the discovery of a small peptide ligand, phoenixin (PNX). Using a bioinformatic approach, two novel peptides PNX-14 and PNX-20 containing 14 and 20 amino acids, respectively, were isolated from diverse tissues including the brain, heart, lung and stomach. Mass spectrometry analysis identified a major and minor peak corresponding to PNX-14 and PNX-20, in rat or mouse spinal cord extracts. With the use of a rabbit polyclonal antiserum, phoenixin immunoreactivity (irPNX) was detected in discrete areas of the rodent brain including several hypothalamic subnuclei and dorsal motor nucleus of the vagus. In addition, irPNX was detected in a population of sensory ganglion cells including dorsal root ganglion, nodose ganglion and trigeminal ganglion, and in cell processes densely distributed to the superficial layers of the dorsal horn, nucleus of the solitary tract and spinal trigeminal tract. irPNX cell processes were also detected in the skin and myenteric plexus, suggesting a brain-gut and/or brain-skin connection. Pharmacological studies show that PNX-14 injected subcutaneously to the nape of the neck of mice provoked dose-dependent repetitive scratching bouts directed to the back of the neck with the hindpaws. Our result suggests that the peptide PNX-14 and/or PNX-20, may serve as one of the endogenous signal molecules transducing itch sensation. Additionally, results from other laboratories show that exogenous PNX may affect a number of diverse behaviors such as memory formation, depression, reproduction, food-intake and anxiolytic-like behaviors.

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Role of Nesfatin-1 in the Reproductive Axis of Male Rat

Cited by 50 publications

References 36 publications

Contingent role of phoenixin and nesfatin‐1 on secretions of the male reproductive hormones

Contingent role of phoenixin and nesfatin‐1 on secretions of the male reproductive hormones

Nesfatin-1: functions and physiology of a novel regulatory peptide

Phoenixin: a novel brain-gut-skin peptide with multiple bioactivity

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