Role of necroptosis in traumatic brain and spinal cord injuries

Hu, Xinli; Xu, Yu; Zhang, Haojie; Li, Yao; Wang, Xiangyang; Ni, Wenfei; Zhou, Kailiang

doi:10.1016/j.jare.2021.12.002

Cited by 23 publications

(10 citation statements)

References 118 publications

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“…Necroptosis of the classical pathway is considered a form of programmed cell death characterized by caspase-8 inhibition, wherein the death process involves the release of cellular contents, including damage-associated molecular patterns. Previous studies have regarded necroptosis as detrimental to SCI recovery, mainly due to the reduction in the number of NSCs and the increase in the in ammatory response [29,30] . However, recent research suggests that necroptosis can alter the mode of exosome secretion and the proteome of exosomes [20] .…”

Section: Discussionmentioning

confidence: 99%

Exosomes Originating from Neural Stem Cells Undergoing Necroptosis Participate in Cellular Communication Following Spinal Cord Injury

Li,

Chen

et al. 2023

Preprint

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In the aftermath of spinal cord injury (SCI), neural stem cells (NSCs) undergo programmed necroptosis, yet the alterations in exosomes and their associated functions remain unexplored. In this study, our data analysis briefly demonstrated that NSCs originate from ependymal cells and experience necroptosis through the classical pathway. Subsequently, NSCs were extracted from embryonic 16-17 mice. We established an in vitro necroptosis model and conducted exosomes extraction. Our findings revealed that necroptosis did not exert a significant impact on the fundamental properties and yield of exosomes. Subsequent to transcriptome sequencing, differentially expressed 108 mRNAs, 104 lncRNAs, 720 circRNAs, and 14 miRNAs were identified, with the first three significantly enriched for the ubiquitin-mediated proteolysis and autophagy signaling pathways. The construction of the competing endogenous RNA network was continued to screen for hubb genes including Tuberous sclerosis 2(Tcs2), Solute carrier family 16 member 3(Slc16a3) and Forkhead box protein P1(Foxp1). Further analysis of cellular communication after SCI revealed that Tsc2 was involved in ependymal cellular communication at 1 and 3 days after SCI through the EGF and MDK signaling pathways, while Slc16a3 participated in cellular communication in the control group and in ependymal cells at 7 days after SCI through the VEGF and MIF signaling pathways. This study introduces novel perspectives on the impacts of necroptosis in SCI.

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Section: Discussionmentioning

confidence: 99%

Exosomes Originating from Neural Stem Cells Undergoing Necroptosis Participate in Cellular Communication Following Spinal Cord Injury

Li,

Chen

et al. 2023

Preprint

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“…Necroptosis is a regulated form of necrotic cell death that is distinct from uncontrolled necrosis. It is initiated by death receptor signaling and involves the sequential activation of receptor-interacting serine/threonine-protein kinases (RIPKs), resulting in the formation of a necrosome complex [ 52 ]. Unlike apoptosis, necroptosis is characterized by cellular swelling, plasma membrane rupture, and the release of DAMP, contributing to inflammation and immune responses [ 53 ].…”

Section: Cell Death Pathways and Panoptosismentioning

confidence: 99%

The role of IFI16 in regulating PANoptosis and implication in heart diseases

Chang,

Wang,

Zhao

et al. 2024

Cell Death Discov.

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Interferon Gamma Inducible Protein 16 (IFI16) belongs to the HIN-200 protein family and is pivotal in immunological responses. Serving as a DNA sensor, IFI16 identifies viral and aberrant DNA, triggering immune and inflammatory responses. It is implicated in diverse cellular death mechanisms, such as pyroptosis, apoptosis, and necroptosis. Notably, these processes are integral to the emergent concept of PANoptosis, which encompasses cellular demise and inflammatory pathways. Current research implies a significant regulatory role for IFI16 in PANoptosis, particularly regarding cardiac pathologies. This review delves into the complex interplay between IFI16 and PANoptosis in heart diseases, including atherosclerosis, myocardial infarction, heart failure, and diabetic cardiomyopathy. It synthesizes evidence of IFI16’s impact on PANoptosis, with the intention of providing novel insights for therapeutic strategies targeting heart diseases.

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“…[17,33] When the activity of caspase-8 is suppressed or inhibited, RIPK1 recruits RIPK3, and the resulting complex recruits MLKL via the RIP homotypic interaction motif (RHIM) in a process that leads to the formation of complex IIb, which is also called the necrosome. [34,35] MLKL undergoes activation via phosphorylation at T357 and S358 sites, leading to its oligomerization and localization to the membrane. Oligomerized MLKL specifically binds to lipids, and by forming pores, it disrupts the integrity of the cell membrane, which finally induces necroptosis.…”

Section: Overview Of Necroptosismentioning

confidence: 99%

Ferroptosis, Necroptosis, and Pyroptosis in Gastrointestinal Cancers: The Chief Culprits of Tumor Progression and Drug Resistance

Zhu

2023

Advanced Science

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In recent years, the incidence of gastrointestinal cancers is increasing, particularly in the younger population. Effective treatment is crucial for improving patients’ survival outcomes. Programmed cell death, regulated by various genes, plays a fundamental role in the growth and development of organisms. It is also critical for maintaining tissue and organ homeostasis and takes part in multiple pathological processes. In addition to apoptosis, there are other types of programmed cell death, such as ferroptosis, necroptosis, and pyroptosis, which can induce severe inflammatory responses. Notably, besides apoptosis, ferroptosis, necroptosis, and pyroptosis also contribute to the occurrence and development of gastrointestinal cancers. This review aims to provide a comprehensive summary on the biological roles and molecular mechanisms of ferroptosis, necroptosis, and pyroptosis, as well as their regulators in gastrointestinal cancers and hope to open up new paths for tumor targeted therapy in the near future.

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Role of necroptosis in traumatic brain and spinal cord injuries

Cited by 23 publications

References 118 publications

Exosomes Originating from Neural Stem Cells Undergoing Necroptosis Participate in Cellular Communication Following Spinal Cord Injury

Exosomes Originating from Neural Stem Cells Undergoing Necroptosis Participate in Cellular Communication Following Spinal Cord Injury

The role of IFI16 in regulating PANoptosis and implication in heart diseases

Ferroptosis, Necroptosis, and Pyroptosis in Gastrointestinal Cancers: The Chief Culprits of Tumor Progression and Drug Resistance

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