Role of Neck Ultrasonography in the Follow-Up of Children Operated on for Thyroid Papillary Cancer

Antonelli, Alessandro; Miccoli, Paolo; Fallahi, Poupak; Grosso, M; Nesti, Claudia; Spinelli, Claudio; Ferrannini, Ele

doi:10.1089/105072503322021142

Cited by 103 publications

(69 citation statements)

References 42 publications

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“…Ultrasonography has been proven to be the most efficient first-line method for the diagnosis of thyroid diseases with advantages of non-invasiveness, real-time scanning, easy performance, and wide availability. Meanwhile, it is also a mean of assessing the degree of involvement of surrounding soft tissues as well as the area involved (9,(14)(15)(16) …”

Section: Resultsmentioning

confidence: 99%

“…It has been reported that preexisting Hashimoto's thyroiditis is a wellrecognized risk factor for the development of PTL, and the average incidence of Hashimoto's thyroiditis in patients with PTL is 80%, ranging from 30-100% in previous studies (12,14). There is also evidence that large cell lymphoma probably evolves from persistent low-grade MALT malignant lymphoma, suggesting a morphological progression from chronic lymphocytic thyroiditis to lowgrade MALT lymphoma, and subsequently, to highgrade large-cell lymphoma (42).…”

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confidence: 99%

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Comparison of sonographic characteristics of primary thyroid lymphoma and anaplastic thyroid carcinoma

Gu¹,

Cui²,

Wang³

et al. 2017

J. Thorac. Dis.

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Background: Although primary thyroid lymphoma (PTL) and anaplastic thyroid carcinoma (ATC) both account for a rare portion of the morbidity of all thyroid malignancies, the therapeutic methods and prognosis for these two diseases are different. The purpose of this study was to investigate the sonographic characteristics of PTL and ATC and to compare the sonographic findings of PTL and ATC. Methods:The study included 42 patients with histopathologically proven PTL (n=27) and ATC (n=15). The Clinical characteristics and sonographic findings were retrospectively reviewed and compared between the two groups.Results: The mean age of patients with ATC was not significantly different from that in patients with PTL (P=0.601). The female-to-male ratio of patients with ATC was significantly lower than that of patients with PTL (P=0.029). Both PTL and ATC commonly present as a relatively large, solid mass on sonography with compressive symptoms, in which hoarseness was seen more frequently in ATC group (66.7%) than in PTL group (14.8%) (P=0.001). There is no significant difference in thyroid size, nodular size, margin, shape, echo texture, echogenicity, cystic change, vascularity and local invasion on sonography between ATC and PTL groups. Echogenic strands, markedly hypoechoic and enhanced posterior echo were seen more frequently in PTL group (92.6%, 92.6%, and 85.2%, respectively) than those in ATC group (6.7%, 60.0%, and 33.3%, respectively) (P<0.05), and calcification was seen more frequently in ATC group (80.0%) than in PTL group (0%) (P<0.001). Three ultrasound patterns were observed for PTL including diffuse type (25.9%), nodular type (48.2%) and mixed type (25.9%), while all ATC cases presented with nodular type (100.0%). AssociatedHashimoto's thyroiditis occurred more frequently in PTL group (59.3%) than in ATC group (20.0%) (P=0.023). Conclusions: Certain sonographic features as a markedly hypoechogenicity, the presence of an enhanced posterior echo and linear echogenic strands, lack of calcification and associated Hashimoto's thyroiditis were valuable for distinguishing PTL from ATC. In contrast, heterogeneous echogenicity, uncircumscribed margin, irregular shape, and vascular pattern were not specific features for differential diagnosis.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Comparison of sonographic characteristics of primary thyroid lymphoma and anaplastic thyroid carcinoma

Gu¹,

Cui²,

Wang³

et al. 2017

J. Thorac. Dis.

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“…For lymph node scanning on the 2 sides of the neck and collarbone, we referred to Antonelli et al (2003) criteria.…”

Section: Thyroid Ultrasound Scanningmentioning

confidence: 99%

Correlation analysis of ultrasonic characteristics, pathological type, and molecular markers of thyroid nodules

Su¹,

Liu²,

Cheng³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The present study was conducted to analyze the correlation between ultrasonic characteristics, pathological type, and molecular markers of thyroid-tumor-related genes as well as to evaluate the diagnosis and prognosis of thyroid nodules. The acoustic characteristics of 130 thyroid specimens were detected. Pathological sectioning and immunohistochemical detection were performed to determine the correlation between tumor gene expression and ultrasonic characteristics. Ultrasonic testing revealed that malignant nodules were normally accompanied by lymph nodes. Expression of the human telomerase reverse transcriptase, Ki67, vascular endothelial growth factor, Ret, and P53 genes exhibited statistically significant differences in malignant, benign, and normal tissues. The performance of thyroid malignant nodules showed different degrees of correlation with the expression of the human telomerase reverse transcriptase, Ki67, VEGF, Ret, and P53 genes. Color Doppler ultrasound is highly sensitive for thyroid nodules and is therefore

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“…Thyroid volume was calculated by the ellipsoid formula, as previously described (14,16,17). The presence of hypoechoic and dyshomogeneous echogenicity was arbitrarily rated at three levels (0 ¼ normal echogenicity; 1 ¼ slight hypoechoic and dyshomogeneous; 2 ¼ severely hypoechoic and dyshomogeneous) to evaluate structural abnormalities of thyroid tissue associated with thyroid autoimmunity (18,19).…”

Section: Ultrasonography Of the Neck And Fnamentioning

confidence: 99%

Increased serum CXCL10 in Graves’ disease or autoimmune thyroiditis is not associated with hyper- or hypothyroidism per se, but is specifically sustained by the autoimmune, inflammatory process

et al. 2006

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Objective: Serum CXCL10 (an interferon-g-inducible chemokine) levels (sCXCL10) are increased in several autoimmune conditions, including Graves' disease (GD) and autoimmune thyroiditis (AT). Longitudinal assessment of sCXCL10 in autoimmune hypo-or hyperthyroidism has not yet been performed. Design and methods: We longitudinally assayed sCXCL10 in the following groups: 1. thirty-three GD and 11 toxic nodular goiter (TNG) patients when hyperthyroid (Hyper) and when reaching euthyroidism (Eu) with methimazole therapy (MMI) 2. sixty-six AT (33 hypothyroid (Hypo) and 33 Eu) patients, basally and after reaching EU (for Hypo) with levothyroxine (L-T 4 ) therapy 3. twenty-two patients with thyroid cancer (CA) under L-T 4 -suppressive treatment, of whom 11 were re-evaluated after L-T 4 withdrawal for diagnostic WBS, and 11 after recombinant TSH (rhTSH) administration 4. thirty-three healthy controls. Results: At initial evaluation, Hyper GD and AT (Hypo significantly higher than Eu) showed significantly higher mean sCXCL10 than all other groups. MMI treatment led to a significant decrease in sCXCL10 only in GD (not in TNG), while restoration of Eu, in Hypo AT, by L-T 4 was not accompanied by significant sCXCL10 change. CA showed sCXCL10 comparable to controls, and both Hypo after L-T 4 withdrawal and rhTSH injection had no effect on sCXCL10. Conclusions: Treatment of Hyper leads to a significant decrease in sCXCL10 only in GD, and this probably depends upon the MMI immunomodulatory effect. L-T 4 correction of Hypo is not accompanied by significant modification of sCXCL10 in AT. Increased sCXCL10 is not associated with Hyper or Hypo per se, but is specifically sustained by the autoimmune inflammatory event occurring in both GD and AT.

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Role of Neck Ultrasonography in the Follow-Up of Children Operated on for Thyroid Papillary Cancer

Cited by 103 publications

References 42 publications

Comparison of sonographic characteristics of primary thyroid lymphoma and anaplastic thyroid carcinoma

Comparison of sonographic characteristics of primary thyroid lymphoma and anaplastic thyroid carcinoma

Correlation analysis of ultrasonic characteristics, pathological type, and molecular markers of thyroid nodules

Increased serum CXCL10 in Graves’ disease or autoimmune thyroiditis is not associated with hyper- or hypothyroidism per se, but is specifically sustained by the autoimmune, inflammatory process

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