Role of NCC in the pathophysiology of hypertension in primary aldosteronism
Germán Ricardo Magaña-Ávila,
María Castañeda-Bueno
Abstract:Purpose of review
An increasing amount of evidence points out to a role for the thiazide-sensitive Na+:Cl- cotransporter, NCC, in the blood pressure alterations observed in conditions of pathologically high or pathologically low aldosterone. Here, we briefly review this evidence that is changing our perception of the pathophysiology of primary aldosteronism.
Recent findings
Although initially NCC was thought to be a direct target of aldosterone, more re… Show more
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