Role of Natural Bio-active Compounds as Antidiabetic Agents

Jiménez-García, Sandra Neli; García-Mier, Lina; Vazquez-Cruz, Moises Alejandro; Ramírez-Gómez, Xóchitl Sofía; Guevara-González, Ramón Gerardo; García‐Trejo, Juan Fernando; Feregrino-Pérez, Ana A.

doi:10.1007/978-3-030-54027-2_15

Cited by 4 publications

(2 citation statements)

References 137 publications

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“…This emphasizes that the OLE might give the best results if it is used as an adjuvant agent with standard antidiabetic drugs. The use of olive leaf extract (OLE) may regulate the level of blood glucose in diabetic rats induced by STZ by enhancing the regeneration of β-cells of the pancreas [ 53 ]. Olive leaf extract is associated with improved glucose homeostasis in humans through the reduction of starch digestion and absorption, and may represent an effective adjunct therapy that normalizes glucose homeostasis in individuals with diabetes [ 15 ].…”

Section: Resultsmentioning

confidence: 99%

Antioxidant and Anti-Diabetic Properties of Olive (Olea europaea) Leaf Extracts: In Vitro and In Vivo Evaluation

Mansour,

Zeitoun,

Abd-Rabou

et al. 2023

Antioxidants

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(1) Objective: The main objective of the current study was to evaluate in vitro and in vivo an antioxidant property of three genotypes of olive leaf extract (OLE) (picual, tofahi and shemlali), and furthermore to assess potential activity in the treatment and/or prevention of diabetes mellitus type II and related implications. (2) Methodology: Antioxidant activity was determined by using three different methods (DDPH assay, reducing power and nitric acid scavenging activity). In vitro α-glucosidase inhibitory activity and hemolytic protective activity were assessed for the OLE. Five groups of male rats were used in in vivo experiment for evaluating the antidiabetic potential of OLE. (3) Results: The genotypes of the extracts of the three olive leaves exhibited meaningful phenolic and flavonoids content with superiority for picual extract (114.79 ± 4.19 µg GAE/g and 58.69 ± 1.03 µg CE/g, respectively). All three genotypes of olive leaves demonstrated significant antioxidant activity when using DPPH, reducing power and nitric oxide scavenging activity with IC50 ranging from 55.82 ± 0.13 to 19.03 ± 0.13 μg/mL. OLE showed a significant α-glucosidase inhibition activity and dose-dependent protection from hemolysis. In vivo experimentation revealed that the administration of OLE alone and the combination of OLE+ metformin clearly restored the blood glucose and glycated hemoglobin, lipid parameters and liver enzymes to the normal level. The histological examination revealed that the OLE and its combination with metformin successfully repaired the liver, kidneys and pancreatic tissues to bring them close to the normal status and maintain their functionality. (4) Conclusion: Finally, it can be concluded that the OLE and its combination with metformin is a promising treatment for diabetes mellitus type 2 due to their antioxidant activity, which emphasizes the potential use of OLE alone or as an adjuvant agent in the treatment protocol of diabetes mellitus type II.

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Section: Resultsmentioning

confidence: 99%

Antioxidant and Anti-Diabetic Properties of Olive (Olea europaea) Leaf Extracts: In Vitro and In Vivo Evaluation

Mansour,

Zeitoun,

Abd-Rabou

et al. 2023

Antioxidants

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“…They are rich in protein, minerals, vitamins, and polyphenols including; phenolic acids and flavonoids [5], [6]. Bioactive compounds include polyphenols, vitamins, dietary fibers, and fatty acids; they have shown positive effects on hypertension, diabetes, and lipid profile [7]. Male rats fed on a high-fat and fructose diet and received different concentrations of chia and quinoa seeds as well as their extracts showed a  ISSN: Int J Public Health Sci, Vol.…”

Section: Introductionmentioning

confidence: 99%

Potential hepato-protective effect of Salvia hispanica (chia) and Chenopodium quinoa (quinoa) in diabetic male albino rats

Eshraa,

El Sahn,

Aborhyem

2024

IJPHS

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Chia and quinoa seeds are novel sources of bioactive compounds that may improve lipid profile, blood glucose homeostasis, and body weight in diabetic rats. This work aims to study the effect of different percentages of chia and quinoa consumption, alone or in a mixture, compared to Metformin drug on regulating lipid profile, blood glucose level, and weight of male diabetic rats. The consumption of quinoa and chia seeds showed a significant decline in fasting blood glucose (FBG), fasting insulin level, Hemoglobin A1C (HbA1c), and Homeostatic Model Assessment for Insulin (HOMA-IR), while the best results were obtained with Metformin and chia seeds. A decrease in mean body weight, triglycerides, total cholesterol, low density lipoprotein (LDL-C), and very low-density lipoprotein (VLDL-C), and an increase in high density lipoprotein (HDL-C) occurred, which was significant when consuming chia and quinoa seeds rather than treatment with metformin. Chia and quinoa seeds could improve blood glucose homeostasis and lipid profile in diabetic rats. These research findings could promote the daily consumption of quinoa and chia as great functional foods that could improve blood glucose homeostasis and lipid profile.

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