Role of nasal allergy in chronic maxillary sinusitis—Diagnostic value of nasal challenge with allergen+

Pelikán, Z; Pelikan-Filipek, M

doi:10.1016/s0091-6749(05)80203-9

Cited by 121 publications

(39 citation statements)

References 12 publications

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“…These findings might explain the high incidence of chronic rhinosinusitis in patients with allergic rhinitis. 11,[17][18][19][20] Our data suggest that the T H genetic background plays an important role in allergy induction, an augmented infectious process, and infection control. A T H 2 genetic tendency leads to an exaggerated allergic response.…”

Section: Commentmentioning

confidence: 99%

Effect of Genetic Background on the Response to Bacterial Sinusitis in Mice

Kirtsreesakul

Luxameechanporn²,

Klemens³

et al. 2006

Arch Otolaryngol Head Neck Surg

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To study the importance of ongoing allergen exposure and T H 1/T H 2 genetic background in augmented bacterial and inflammatory responses in allergic and infected mice.Design: BALB/c and C57BL/6 mice were made allergic to ovalbumin. After 1 day of intranasal allergen exposure, they were inoculated intranasally with Streptococcus pneumoniae. The numbers of bacteria and inflammatory cells in the sinuses were determined, and nasal responsiveness to histamine was assessed.Results: Infected BALB/c and C57BL/6 mice that received ongoing ovalbumin challenge following intraperitoneal sensitization showed significantly greater bacterial load and phagocyte level compared with the infected-only mice. Differences were diminished after the allergen challenge was stopped. Allergic and infected C57BL/6 mice showed fewer bacteria and phagocytes compared with the allergic and infected BALB/c mice. Surprisingly, in contrast to the nonallergenic C57BL/6 mice, the infected BALB/c mice showed a larger number of bacteria 28 days after infection.Conclusions: Ongoing allergic reaction augments bacterial load in both BALB/c and C57BL/6 mice and induces nasal hyperreactivity to histamine. Allergic and infected C57BL/6 mice show less allergic inflammation and bacterial load compared with allergic and infected BALB/c mice. Stopping allergen exposure reduces the response. Infected BALB/c mice, which favor a T H 2 response, were less able to clear infection than C57BL/6 mice, which favor a T H 1 response. Inflammation and bacterial load are affected by genetic background of mice and ongoing allergen stimulation.

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Section: Commentmentioning

confidence: 99%

Effect of Genetic Background on the Response to Bacterial Sinusitis in Mice

Kirtsreesakul

Luxameechanporn²,

Klemens³

et al. 2006

Arch Otolaryngol Head Neck Surg

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“…(12)(13)(14)(15) Some authors, while studying patients with allergic rhinitis, have demonstrated that nasal challenge with allergens can cause symptoms and radiological abnormalities that are consistent with sinusitis. (2) Others have used nasal challenge with antigens to induce influx of eosinophils into the sinuses of allergic volunteers. (16) Biopsy studies of paranasal sinus mucosa have demonstrated that the most prominent histological characteristic in patients with chronic sinusitis is eosinophil infiltrate.…”

Section: Discussionmentioning

confidence: 99%

“…There is evidence that the inflammatory process in the paranasal sinuses may have an allergic etiology. (2)(3)(4) It has been consistently demonstrated that there is an interrelationship between the upper and lower airways in asthma and allergic rhinitis. Analysis of a random sample of patients who participated in the European Community Respiratory Health Survey demonstrated that asthma was strongly correlated with rhinitis, even in nonatopic patients.…”

Section: Introductionmentioning

confidence: 99%

Alterações tomográficas de seios paranasais em pacientes adultos com rinite alérgica

et al. 2005

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Objective: To evaluate, using computerized tomography, the frequency of paranasal sinus involvement in patients with allergic rhinitis. Methods: From among outpatients diagnosed with rhinitis and complaining of nasal obstruction, 60were selected for evaluation. The patients were submitted to anterior rhinoscopy, skin prick test for reactivity to aeroallergens and computed tomography of the paranasal sinuses. In addition, questionnaires designed to evaluate symptom severity were administered. The Lund score was used to evaluate paranasal sinus involvement on computed tomography scans. Results: Computed tomography scans of the paranasal sinuses were abnormal in 31 patients (52%).The sum of the largest diameters of cutaneous reactions to the aeroallergens, symptom severity and anterior rhinoscopy findings did not differ between patients with paranasal sinus involvement and those without. All the patients with paranasal sinus abnormalities also presented ostiomeatal complex abnormalities, whereas only 11 patients (38%) without paranasal sinus involvement presented such abnormalities (p < 0.01). Conclusion: In a sample of patients with allergic rhinitis, the frequency of paranasal sinus abnormalities on computed tomography scans was elevated and did not correlate with symptom severity or skin prick test reactivity but was correlated with osteomeatal complex obstruction.

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“…Pelikan & Pelikan-Filipek, à investigação por exame radiológico de seios da face pré e pós-provocação nasal com alérgeno, encontraram acentuação do espessamento da mucosa e opacificação dos seios paranasais em 32/73 pacientes e demonstraram a relação entre sinusite e rinite alérgica 20 .…”

Section: Discussionunclassified

Mediadores inflamatórios, citograma em lavado nasal e tomografia computadorizada de seios paranasais em crianças atópicas

Kovalhuk¹,

Carvalho²

2001

J. Pediatr. (Rio J.)

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ResumoObjetivos: os objetivos deste estudo foram avaliar a celularidade e os mediadores inflamatórios no lavado nasal (LN) e a extensão de comprometimento da mucosa dos seios paranasais, em atópicos assintomáticos para sinusite.Métodos: foram estudados 48 atópicos com rinite alérgica (RA), 33/48 com asma; 13 crianças não atópicas constituíram o grupo controle. Foram excluídos os casos com sinusite aguda, crônica ou recorrente. A extensão de lesão da mucosa paranasal, avaliada por tomografia computadorizada (TC) coronal dos seios da face (SF), foi graduada por escore padronizado (0-30). Escore maior ou igual a 12 indicava comprometimento extenso da mucosa dos SF. O LN foi obtido para quantificar a celularidade total e diferencial. Uma alíquota do sobrenadante foi usada para dosagem de mediadores inflamatórios: Interleucina-8 (IL-8), Mieloperoxidase (MPO), Proteína catiônica eosinofílica (ECP). A albumina foi usada como marcador de permeabilidade vascular. Estas determinações foram realizadas em amostras do fluido nasal (FN) de todos os atópicos e em 6/13 dos casos-controle. Foram realizados nos 3 grupos hemograma e espirometria.Resultados: o comprometimento da mucosa paranasal foi extenso em 7/33 (21%) dos asmáticos (Grupo I), 2/15 (13%) dos pacientes com RA (Grupo II). No grupo controle (Grupo III) o maior escore de TC foi 7. A contagem total de células e de eosinófilos/ml e a concentração de albumina do FN foram maiores entre asmáticos com escore de TC acima de 12. O nível de IL-8, o número de neutrófilos e de células epiteliais/ml no FN foram semelhantes nos 3 grupos. Os atópicos (n=48) apresentaram uma correlação positiva entre escore de TC, eosinofilia periférica, número de eosinófilos/ml e concentração de ECP no FN. Houve uma associação entre o número de neutrófilos e concentrações de IL-8 e MPO e entre IL-8 e eosinófilos.Conclusões: em asmáticos assintomáticos para sinusite, o comprometimento extenso da mucosa paranasal está associado à eosinofilia periférica e do lavado nasal e à ativação celular. A infiltração e a ativação de neutrófilos não estavam relacionadas com a maior extensão de lesão da mucosa paranasal.J Pediatr (Rio J) 2001; 77 (4): 271-8: sinusite, asma, rinite, tomografia computadorizada, lavado nasal, interleucina-8, mieloperoxidase, proteína catiônica eosinofílica. AbstractObjective: the aims of this study were to evaluate inflammatory cells, the profile of inflammatory mediators in nasal lavage (NL), and the involvement of the paranasal mucosa in atopic infants with no symptoms of sinusitis.Methods: 48 atopic patients with allergic rhinitis (AR), and 33/ 48 patients with asthma were studied; the control group consisted of 13 nonatopic children. Those individuals with acute, chronic or recurrent sinusitis were excluded. The involvement of the paranasal mucosa was assessed by coronal computed tomography (CT) and graded by a standard protocol (0-30). A CT score greater than or equal to 12 indicated extensive involvement. Nasal lavage was used to quantify total and differential nasal cell coun...

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Role of nasal allergy in chronic maxillary sinusitis—Diagnostic value of nasal challenge with allergen+

Cited by 121 publications

References 12 publications

Effect of Genetic Background on the Response to Bacterial Sinusitis in Mice

Effect of Genetic Background on the Response to Bacterial Sinusitis in Mice

Alterações tomográficas de seios paranasais em pacientes adultos com rinite alérgica

Mediadores inflamatórios, citograma em lavado nasal e tomografia computadorizada de seios paranasais em crianças atópicas

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