Role of Mycoplasma and Ureaplasma Species in Female Lower Genital Tract Infections

Patel, M.; Nyirjesy, Paul

doi:10.1007/s11908-010-0136-x

Cited by 41 publications

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References 34 publications

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“…Ureaplasma species (Ureaplasma parvum and Ureaplasma urealyticum) and Mycoplasma species (Mycoplasma hominis and Mycoplasma genitalium), generally referred to as "genital mycoplasmas", have been associated to a large variety of infections in adults and infants, in particular may be responsible of nogonococcal urethritis, cervicitis, pelvic inflammatory disease and adverse pregnancy outcome [1][2][3][4][5][6]. However, since they are found in the vagina of up to 80% of pregnant and non-pregnant women [7], their pathogenic role is difficult to prove.…”

Section: Introductionmentioning

confidence: 99%

“…Tetracyclines, macrolides, and quinolones can be used for treatment of infections caused by genital mycoplasmas [6]. While ureaplasmas are generally susceptible to macrolides, they are resistant to lincosamides except in high concentrations.…”

Section: Introductionmentioning

confidence: 99%

“…M. hominis, in contrast, is naturally resistant to C14 and C15 macrolides (e.g. clarithromycin, erythromycin, azithromycin and roxithromycin), but susceptible to 16-membered macrolides (josamycin and miocamycin) and lincomycin [6]. Increasing resistance to fluoroquinolones have been documented in several reports [8,9].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Mycoplasma IES, Mycofast Revolution and Mycoplasma IST2 to detect genital mycoplasmas in clinical samples

D’Inzeo

Angelis

Fiori

et al. 2017

J Infect Dev Ctries

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Introduction: Culture is regarded as the gold standard for the detection of genital mycoplasma in clinical samples. Commercially available diagnostic kits, based on liquid broth cultures, provide interesting alternatives to conventional culture. We assessed the laboratory performances of Mycoplasma IES (IES), the Mycofast Revolution (REV) and Mycoplasma IST 2 (IST2) compared to A7 agar plates for the detection of Ureaplasma urealyticum and Mycoplasma hominis in clinical samples. Methodology: From April to July 2013, endocervical or vaginal samples were collected from sexually active women with abnormal vaginal discharge. Each specimen was tested in parallel using the three commercial kits and the A7 agar plates. Results: A total of 303 samples were included in this study, 35.6% (108/303) of which were positive on A7 plates. Sensitivities for the detection of U. urealyticum of IES, REV and IST2 were 100%, 96.2% and 95.3%, respectively while those for M. hominis were of 92.8%, 92.8% and 85.7%, respectively. Specificity was 100% for the 3 methods. Concerning antimicrobial susceptibility testing, full agreement between IES and REV was documented. Conclusions: The Mycoplasma IES kit was found to be equivalent or superior compared to other commercial culture-based assays for a rapid and accurate identification of U. urealyticum and M. hominis and detection of resistance. It might be considered a cost-effective tool for detection of these organisms, particularly attractive in developing countries.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparison of Mycoplasma IES, Mycofast Revolution and Mycoplasma IST2 to detect genital mycoplasmas in clinical samples

D’Inzeo

Angelis

Fiori

et al. 2017

J Infect Dev Ctries

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“…Mycoplasmas infecting humans mainly colonize the mucosal surfaces of the respiratory and genitourinary tracts [Cassell et al, 1994, Patel & Nyirjesy, 2010Taylor-Robinson, 1996]. The mycoplasma species commonly isolated from humans and their attributes are listed in Lo et al,1993;b Lo et al, 1992;c Yáñez et al, 1999. and M. penetrans are primarily urogenital residents, but exceptionally they can be isolated from other unusual tissues and organs, especially in immunocompromised patients or in patients undergoing solid organ transplantation [Cassel et al, 1993;Waites & Talkington, 2004;Waites et al, 2008].…”

Section: Relevant Features Of Mycoplasmasmentioning

confidence: 99%

Molecular Diagnostics of Mycoplasmas: Perspectives from the Microbiology Standpoint

Flores-Medina¹,

Soriano-Becerril²,

Díaz-García³

2012

Polymerase Chain Reaction

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“…The organism could cause pyelonephritis, pelvic inflammatory disease, postpartum and postabortion fever in addition to extragenital diseases including septicemia, joint infections, central nervous system infections, respiratory tract infections and wound infections particularly after surgery (Thomsen and Lindskov, 1979;Taylor-Robinson, 1996a;1996b;Stellrecht et al, 2004;Waites et al, 2005;Totten et al, 2008;Patel and Nyirjesy, 2010;Taylor-Robinson and Furr, 2010;Taylor-Robinson and Jensen, 2011). In newborn children, this pathogen can also can cause meningitis, pneumonia and abcess (Pereyre et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

DETECTION OF <i>MYCOPLASMA HOMINIS</i> IN PATIENTS WITH URINARY TRACT INFECTIONS

Abdul-Wahab¹

2014

American Journal of Infectious Diseases

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Mycoplasma hominis is one of the well known genital mycoplasma agent that has been recognized as potentially pathogenic species and associated with various infectious diseases in adult men and woman. The organism could cause pelvic inflammatory disease, postpartum, postabortion fever and pyelonephritis. The Aim of this prospective study was to detemine the occurrence and prevalence of Mycoplasma hominis in patients with urinary tract infections, since they are usually not detected by routine microbiological examination of urine samples in laboratory department. For this purpose, Culture method was to be attempted as the current laboratory methods of choice for detection urogenital mycoplasmas infections. This study was designed as a case-control study in which a total of 100 patients with mean age of the of 42.78±22.49 (95% CI = 39-49.17) in case group as well as a mean age of 48.18±18.81 ((95% CI = 42.83-53.53) in the control group. The patients of both sexes were investigated for the presence of M. hominis and they were admitted to the urology department at asser central hospital in Abha (a city in southwest region of Saudi Arabia), during over a period of one year (February, 2013-March, 2014. A detailed history with specific urinary symptoms and signs was obtained as a result. These patients were divided into two groups: The first group (or case group) and the second group (or control group): The case group, included 50 symptomatic patients who had been admitted in hospital and they were examined for the presence of one or more of the following specific urinary symptoms and signs: Urinary frequency, dysuria, suprapubic/pelvic pain. Unlike the case group, the control group included 50 asymptomatic patients who were free of any specific urinary symptoms and they were matched by the first group for their age index. First voided urine specimens were tested using urine microscopy, culture for M hominis was performed and the isolates were identified serologically by growth inhibition test (disc method). In the case group, 8 cases out of 50 and in control group 1 out 50 were positive for M. hominis infection. The incidence of M. hominis was higher and statistically significant among case symptomatic patients group (8/50, 16%) than control asymptomatic patients group patients (1/50, 2%). On applying tests of significance to the observed data for isolation of Mycolplasma hominis among cases and controls, the values were found to statistically significant. Chisquare test with Yate's correction [χ AJIDArabia. Infection caused by M hominis was associated with higher incidence rate in patients with symptomatic urinary tract diseases. Further work studies is needed for their rapid detection of these organism in urine samples using other diagnostic methods such as PCR. Further knowledge of the role and the effect of this pathogen in patients with urinary tract infections can be a prospective field of study.

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Role of Mycoplasma and Ureaplasma Species in Female Lower Genital Tract Infections

Cited by 41 publications

References 34 publications

Comparison of Mycoplasma IES, Mycofast Revolution and Mycoplasma IST2 to detect genital mycoplasmas in clinical samples

Comparison of Mycoplasma IES, Mycofast Revolution and Mycoplasma IST2 to detect genital mycoplasmas in clinical samples

Molecular Diagnostics of Mycoplasmas: Perspectives from the Microbiology Standpoint

DETECTION OF <i>MYCOPLASMA HOMINIS</i> IN PATIENTS WITH URINARY TRACT INFECTIONS

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