Role of Mushrooms in Neurodegenerative Diseases

Lee, Wooseok; Fujihashi, Ayaka; Govindarajulu, Manoj; Ramesh, Sindhu; DeRuiter, Jack; Majrashi, Mohammed; Almaghrabi, Mohammed; Nadar, Rishi M.; Moore, Timothy; Agrawal, Dinesh Chandra; Dhanasekaran, Muralikrishnan

doi:10.1007/978-981-13-6382-5_8

Cited by 9 publications

(4 citation statements)

References 65 publications

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“…Both edible and wild mushrooms play an imperative role in the prevention of many age-related neurological disorders. Some of these mushrooms, such as Hericium, Ganoderma, Sarcodon, Antrodia, Pleurotus, Lignosus , and Grifola , are used in the treatment of nervous system diseases (such as neurotoxicity) and ensure the protection of the nervous system [ 125 , 126 ]. In a study conducted on Basidiomycetes, Ascomycetes , and Hericium mushrooms, it was reported that these mushrooms exhibit a wide range of health benefits, such as immunological, anticancer, neuroprotective, nephroprotective, and characteristics due to the presence of various biologically active ingredients with many pharmaceutical properties [ 127 ].…”

Section: Pharmacological and Pharmaceutical Propertiesmentioning

confidence: 99%

A review of the therapeutic and biological effects of edible and wild mushrooms

Anusiya¹,

Prabu²,

Yamini³

et al. 2021

Bioengineered

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Throughout history, mushrooms have occupied an inseparable part of the diet in many countries. Mushrooms are considered a rich source of phytonutrients such as polysaccharides, dietary fibers, and other micronutrients, in addition to various essential amino acids, which are building blocks of vital proteins. In general, mushrooms offer a wide range of health benefits with a large spectrum of pharmacological properties, including antidiabetic, antioxidative, antiviral, antibacterial, osteoprotective, nephroprotective, hepatoprotective, etc. Both wild edible and medicinal mushrooms possess strong therapeutic and biological activities, which are evident from their in vivo and in vitro assays. The multifunctional activities of the mushroom extracts and the targeted potential of each of the compounds in the extracts have a broad range of applications, especially in the healing and repair of various organs and cells in humans. Owing to the presence of the aforementioned properties and rich phytocomposition, mushrooms are being used in the production of nutraceuticals and pharmaceuticals. This review aims to provide a clear insight on the commercially cultivated, wild edible, and medicinal mushrooms with comprehensive information on their phytochemical constituents and properties as part of food and medicine for futuristic exploitation. Future outlook and prospective challenges associated with the cultivation and processing of these medicinal mushrooms as functional foods are also discussed.

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Section: Pharmacological and Pharmaceutical Propertiesmentioning

confidence: 99%

A review of the therapeutic and biological effects of edible and wild mushrooms

Anusiya¹,

Prabu²,

Yamini³

et al. 2021

Bioengineered

View full text Add to dashboard Cite

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“…( 7) Group of neurodegenerative diseases Some medicinal mushrooms such as Grifola frondosa, Hericium erinaceus, Lignosus rhinocerotis, Paxillus panuoides, Pleurotus giganteus, and Sarcodon scabrosus can improve human cognitive functions. Many bioactive ingredients can be used from this group of mushrooms against many diseases such as hericenones, scabronines, ganoderic acids, and aqueous and ethanolic extracts [17,188]. (8) DNA damage group This group includes mushrooms such as Agaricus blazei and Ganoderma lucidum, which have extracts such as polysaccharides that may work against DNA damage [189].…”

Section: (V) Antiviral Mushrooms Against Other Virusesmentioning

confidence: 99%

Edible Mushrooms for Sustainable and Healthy Human Food: Nutritional and Medicinal Attributes

et al. 2022

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Global food production faces many challenges, including climate change, a water crisis, land degradation, and desertification. These challenges require research into non-traditional sources of human foods. Edible mushrooms are considered an important next-generation healthy food source. Edible mushrooms are rich in proteins, dietary fiber, vitamins, minerals, and other bioactive components (alkaloids, lactones, polysaccharides, polyphenolic compounds, sesquiterpenes, sterols, and terpenoids). Several bioactive ingredients can be extracted from edible mushrooms and incorporated into health-promoting supplements. It has been suggested that several human diseases can be treated with extracts from edible mushrooms, as these extracts have biological effects including anticancer, antidiabetic, antiviral, antioxidant, hepatoprotective, immune-potentiating, and hypo-cholesterolemic influences. The current study focuses on sustainable approaches for handling edible mushrooms and their secondary metabolites, including biofortification. Comparisons between edible and poisonous mushrooms, as well as the common species of edible mushrooms and their different bioactive ingredients, are crucial. Nutritional values and the health benefits of edible mushrooms, as well as different biomedical applications, have been also emphasized. Further research is needed to explore the economic sustainability of different medicinal mushroom bioactive compound extracts and their potential applications against emerging diseases such as COVID-19. New approaches such as nano-biofortification are also needed to supply edible mushrooms with essential nutrients and/or to increase their bioactive ingredients.

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“…In this field, the potential role of mushrooms for AD treatment or prevention, has been highlighted [ 37 ]. Studies using mushroom extracts and compounds have demonstrated neuroprotective, neuromodulatory, and immunomodulatory activities, as well as an anti-inflammatory and antioxidant potential in neurodegenerative diseases [ 37 , 38 , 39 ]. Well know mushroom species such as Ganoderma lucidum (Curtis) P.…”

Section: Introductionmentioning

confidence: 99%

Tracing the Path between Mushrooms and Alzheimer’s Disease—A Literature Review

et al. 2023

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Alzheimer’s disease (AD) is well-known among neurodegenerative diseases for the decline of cognitive functions, making overall daily tasks difficult or impossible. The disease prevails as the most common form of dementia and remains without a well-defined etiology. Being considered a disease of multifactorial origin, current targeted treatments have only managed to reduce or control symptoms, and to date, only two drugs are close to being able to halt its progression. For decades, natural compounds produced by living organisms have been at the forefront of research for new therapies. Mushrooms, which are well-known for their nutritional and medicinal properties, have also been studied for their potential use in the treatment of AD. Natural products derived from mushrooms have shown to be beneficial in several AD-related mechanisms, including the inhibition of acetylcholinesterase (AChE) and β-secretase (BACE 1); the prevention of amyloid beta (Aβ) aggregation and neurotoxicity; and the prevention of Tau expression and aggregation, as well as antioxidant and anti-inflammatory potential. Several studies in the literature relate mushrooms to neurodegenerative diseases. However, to the best of our knowledge, there is no publication that summarizes only AD data. In this context, this review aims to link the therapeutic potential of mushrooms to AD by compiling the anti-AD potential of different mushroom extracts or isolated compounds, targeting known AD-related mechanisms.

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Role of Mushrooms in Neurodegenerative Diseases

Cited by 9 publications

References 65 publications

A review of the therapeutic and biological effects of edible and wild mushrooms

A review of the therapeutic and biological effects of edible and wild mushrooms

Edible Mushrooms for Sustainable and Healthy Human Food: Nutritional and Medicinal Attributes

Tracing the Path between Mushrooms and Alzheimer’s Disease—A Literature Review

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