Role of muscle-derived cells in hematopoietic reconstitution of irradiated mice

Pang, Wenxin

doi:10.1182/blood.v95.3.1106

Cited by 39 publications

(8 citation statements)

References 3 publications

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“…Moreover, it was reported that enriched HSCs could produce cardiac myocytes and endothelial cells (Jackson et al 2001); purified HSCs could produce functional hepatocytes (Lagasse et al 2000); and single HSCs could produce epithelial cells of the liver, gut, lung, and skin (Krause et al 2001). It was also reported that BM stromal cells (MSCs) could produce brain astrocytes (Kopen et al 1999), and cells enriched for stem cells from adult mouse skeletal muscle could produce blood cells (Gussoni et al 1999, Jackson et al 1999, Pang 2000. Perhaps most remarkable of all, it was reported that NSCs from adult mouse brain produce blood cells and immune cells (Bjornson et al 1999), skeletal muscle cells (Galli et al 2000), and, when injected into a blastocyst, a wide variety of embryonic cell types (Clarke et al 2000).…”

Section: Claims For Adult Stem Cell Plasticitymentioning

confidence: 99%

“…In most cases, a mixed population of donor cells was used, and thus the nature of the cells that apparently switched lineage is unknown. An example of how this problem can lead to misinterpretation is provided by the initial reports that skeletal muscle stem cells (satellite cells) could produce blood cells (Gussoni et al 1999, Jackson et al 1999, Pang 2000. When the blood-forming cells from muscle were better characterized, they turned out to be HSCs present in muscle, rather than satellite cells (Asakura et al 2002, McKinney-Freeman et al 2002, Seale et al 2000.…”

Section: Identification Of the Switching Cellsmentioning

confidence: 99%

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Adult Stem Cell Plasticity: Fact or Artifact?

Raff

2003

Annu. Rev. Cell Dev. Biol.

261

200

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There has been unprecedented recent interest in stem cells, mainly because of the hope they offer for cell therapy. Adult stem cells are an attractive source of cells for therapy, especially in view of the recent claims that they are remarkably plastic in their developmental potential when exposed to new environments. Some of these claims have been either difficult to reproduce or shown to be misinterpretations, leaving the phenomenon of adult stem cell plasticity under a cloud. There are, however, other examples of plasticity where differentiated cells or their precursors can be reprogrammed by extracellular cues to alter their character in ways that could have important implications for cell therapy and other forms of regenerative treatment.

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Section: Claims For Adult Stem Cell Plasticitymentioning

confidence: 99%

Section: Identification Of the Switching Cellsmentioning

confidence: 99%

Adult Stem Cell Plasticity: Fact or Artifact?

Raff

2003

Annu. Rev. Cell Dev. Biol.

261

200

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Section: Evidence For and Against Lineage Promiscuity By Adult Stem Cmentioning

confidence: 92%

Integrative molecular and developmental biology of adult stem cells

Bunting

Hawley

2003

Biology of the Cell

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Stem cells are believed to be important for regeneration of several adult tissues. Recently, adult stem cells with very broad differentiation potential have been identified although whether they represent vestigial primitive pluripotent stem cells or products of extremely rare de-differentiation events involving tissue-specific stem cells is not known. Transdifferentiation of tissue-specific stem cells across lineage boundaries has also been demonstrated but the relative inefficiency of the process in vivo, even in the presence of tissue damage, questions whether such a mechanism is of physiologic relevance. Interestingly, among adult stem cells, the capacity for lineage switching appears to be greatest in stem cells that can be cultured ex vivo for extended periods. If the normal cell fate decisions of diverse adult stem cell types could be reliably redirected at high frequency in situ, possible regenerative therapies for a wide variety of diseases could be envisioned. An integrated understanding of the transcriptional regulatory networks that comprise the various adult stem cell entities as well as the signaling pathways governing their differentiation into therapeutically useful cell types will facilitate clinical application of these exciting findings.

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“…The muscle SP cells were also capable of contributing at low levels to skeletal muscle engraftment. Several other groups have confirmed that cells derived from murine skeletal muscle have hematopoietic repopulating potential following intravenous transplantation [76,77,78]. Goodell and colleagues transplanted muscle cells that had been cultured for 5 days and, using a competitive repopulation assay, showed that these cells had approximately 10 to 14 times more hematopoietic repopulating activity than whole bone marrow [76].…”

Section: Unexpected Differentiative Potential Of Hscs and Other Tissumentioning

confidence: 98%

The Tao of Hematopoietic Stem Cells: Toward a Unified Theory of Tissue Regeneration

Bunting

Hawley

2002

The Scientific World JOURNAL

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Hematopoietic stem cells (HSCs) are the best studied of the tissue-specific stem cells. By definition, HSCs have long been regarded as restricted to formation of blood cells of both the lymphoid and myeloid lineages. HSCs residing in the bone marrow microenvironment have self-renewal capacity and can repopulate the hematopoietic system of irradiated transplant recipients for the lifetime of the individual. Therefore, HSCs are extremely important targets for gene therapy applications aimed toward the treatment of inherited and acquired blood disorders. However, recent studies have suggested that a subpopulation of HSCs may have the ability to contribute to diverse cell types such as hepatocytes, myocytes, and neuronal cells, especially following induced tissue damage. Preclinical amelioration of liver disease and myocardial infarcts by HSC-enriched bone marrow cell populations raises the possibility that HSC transplants have the potential to provide therapeutic benefit for a wide variety of diseases. These surprising findings contradict the dogma that adult stem cells are developmentally restricted. Extrapolation of these findings to the clinic will be facilitated by prospective identification of the stem cells that possess this developmental plasticity. Furthermore, characterization of the signaling pathways and molecular determinants regulating the remarkable transdifferentiation capacity of these stem cells may provide insight into novel approaches for modulating frequency of differentiative potential.

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Role of muscle-derived cells in hematopoietic reconstitution of irradiated mice

Cited by 39 publications

References 3 publications

Adult Stem Cell Plasticity: Fact or Artifact?

Adult Stem Cell Plasticity: Fact or Artifact?

Integrative molecular and developmental biology of adult stem cells

The Tao of Hematopoietic Stem Cells: Toward a Unified Theory of Tissue Regeneration

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