Role of Mucins from Human Whole Saliva in the Protection of Tooth Enamel against Demineralization in vitro

Amerongen, A. van Nieuw; Oderkerk, C.H.; Driessen, A.

doi:10.1159/000261033

Cited by 119 publications

(97 citation statements)

References 22 publications

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“…The teeth will be protected by it against acidic attacks both by the salivary buffer systems and by the pellicle of salivary proteins that is formed on dental enamel [20]. In addition, salivary antimicrobial systems, including antimicrobial proteins and peptides, e.g.…”

Section: Discussionmentioning

confidence: 99%

Xerostomia Management for Pediatric Oncology Patients with Lactoperoxidase Included Oral Health Care Products

B¹

2013

Dentistry

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Aim: Evaluating the efficacy of lactoperoxidase included oral care products for xerostomia in children with cancer undergoing chemotherapy and / or radiotherapy and to present an easy to follow oral care protocol. Design:The study subjects consisted of twenty one pediatric cancer patients (mean age of 11,3±) with either leukemia or lymphoma used lactoperoxidase-system-containing mouth rinse (Biotene ® ) combined with (Biotene ® ) gel or (Biotene ® ) chewing gum for 3 weeks. Unstimulated saliva samples were collected at the base line and 4 weeks after the usage of the products. They were analyzed for selected biochemical factors and subjective symptoms as intra-oral dryness (xerostomia), eating ability and oral discomfort were graded by visual analogue scale. Results:No major changes occurred in the level of saliva Thiocyanite and Peroxidase activity, but there was a increase in salivary pH and also salivary flow rate was notably higher in groups using Lactoperoxidase products. Changes related to buffering capacity of saliva were also recorded. Conclusion:There is no clearly effective treatment for xerostomia but we have observed in our practice that the use of non-immunologic antimicrobial agents relieves subjective oral symptoms in most xerostomic pediatric patients.

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Section: Discussionmentioning

confidence: 99%

Xerostomia Management for Pediatric Oncology Patients with Lactoperoxidase Included Oral Health Care Products

B¹

2013

Dentistry

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“…Intact histatins were identified in vivo and are responsible for salivary pellicle formation [27]. Moreover, the organic components are attributed to anti-demineralization properties [27,28]. The mucins prevent desiccation because their viscoelastic properties provide adequate lubrication and contribute to protector effect of salivary pellicle against metalloproteinases and biocorrosion [28].…”

Section: Saliva Roles As Protective Signaling and Diagnostic Agentmentioning

confidence: 99%

“…The mucins prevent desiccation because their viscoelastic properties provide adequate lubrication and contribute to protector effect of salivary pellicle against metalloproteinases and biocorrosion [28]. Before contacting the enamel, acids must diffuse through a film of mucins, glycoproteins and other enzymes to reach the tooth [28,29].…”

Section: Saliva Roles As Protective Signaling and Diagnostic Agentmentioning

confidence: 99%

“…On the other hand, the presence of calcium and total protein is responsible to form the salivary pellicle and to difficult the acids effects on dental surface [28,34]. This pellicle acts as diffusion barrier of serous saliva in intimate contact and strongly adhered to the dental surface [17,36].…”

Section: Saliva Roles As Protective Signaling and Diagnostic Agentmentioning

confidence: 99%

“…This pellicle acts as diffusion barrier of serous saliva in intimate contact and strongly adhered to the dental surface [17,36]. Furthermore, many proteins present salivary pellicle, which shows an important role against dental chemistry degradation [17,28,34,36].…”

Section: Saliva Roles As Protective Signaling and Diagnostic Agentmentioning

confidence: 99%

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The dentin chemical degradation and saliva roles on Noncarious Cervical Lesions – literature review

Souza

Machado

Pereira

et al. 2018

Rev. Odonto Ciênc. (Online)

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This review elucidates the dental structure chemical degradation and saliva roles in the origin and progression of NCCLs. Dentin chemical degradation is a predominant factor that contributes to the origin and progression of noncarious cervical lesions, which includes the biocorrosive factors: chemical, biochemical, electrochemical and piezoelectric dentin effects. The biocorrosive process involves endogenous and exogenous agents. As regard to saliva roles, the flow rate, buffering capacity, pH and its protein composition are valid parameters to identify biocorrosive factors. Thus, the association of acids agents, altered salivary parameters and specifics proteases are important conditions to promote dental wear. It can be concluded that endogenous and exogenous acids agents, salivary parameters and specific oral biomarkers are important to support the diagnostic and management of dental wear and noncarious cervical lesions.Keywords: diet; gastroesophageal reflux; saliva; tooth erosion; tooth wear.A degradação química da dentina e os papéis da saliva nas lesões cervicais não cariosas -revisão da literatura RESUMO Esta revisão elucida a degradação química da estrutura dental e os papéis da saliva na origem e progressão de lesões cervicais não cariosas. A degradação química da dentina é um fator predominante que contribui para a origem e progressão de lesões cervicais não cariosas que incluem fatores biocorrosivos: efeitos químicos, bioquímicos, eletroquímicos e proteolíticos da dentina. O processo biocorrosivo envolve agentes endógenos e exógenos. No que diz respeito aos papéis da saliva, a taxa de fluxo, a capacidade de tamponamento, o pH e sua composição proteica são parâmetros válidos para identificar fatores biocorrosivos. Assim, a associação de agentes ácidos, parâmetros salivares alterados e proteases específicas são condições importantes para promover o desgaste dental. Pode-se concluir que os agentes ácidos endógenos e exógenos, parâmetros salivares e biomarcadores orais específicos são importantes para apoiar o diagnóstico e manejo do desgaste dentário e lesões cervicais não cariosas.

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Making sense of medieval mouths: Investigating sex differences of dental pathological lesions in a late medieval Italian community

Trombley

Beauchesne

Goodson

et al. 2019

American J Phys Anthropol

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Objectives: Bioarchaeological investigations of sex-based differences in the prevalence of dental pathological lesions, particularly caries, have drawn considerable attention, and out of this work, two dominant models have emerged. Traditionally, the first model interprets sex-related patterns in caries as a product of gendered differences in diet. A more recent model interprets a generally higher propensity for caries prevalence in females in light of reproductive ecology. To test the hypothesis that females have higher risk of caries in accordance with reproductive ecology, we examined and analyzed caries prevalence and other potentially synergistic oral pathological lesions in a late medieval (A.D. 1300-1500) Italian archaeological sample.Materials and methods: We examined sex-and age-related prevalence in caries and other oral pathological lesions in a late medieval Italian skeletal assemblage excavated from Villamagna consisting of 38 females and 37 males (n = 1,534 teeth). We examined age-and sex-related patterns in six dental traits: antemortem tooth loss, caries, calculus, periapical inflammation, tooth wear, and periodontitis.Results: Significant age-related increases in antemortem tooth loss, caries, calculus, and tooth wear were observed in both males and females. However, there was a lack of expected sex differences in oral pathological lesions, with instead older males exhibiting significantly more antemortem tooth loss and corrected caries than females.Discussion: Results are discussed in relation to the ethnohistoric context of medieval rural dietary practices as well as biomedical salivary literature, which suggest that dietary changes throughout the life course may have facilitated trade-offs that buffered females from higher rates of dental pathological lesions. K E Y W O R D Sbioarchaeology, caries, dental anthropology, reproductive ecology, saliva

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Role of Mucins from Human Whole Saliva in the Protection of Tooth Enamel against Demineralization in vitro

Cited by 119 publications

References 22 publications

Xerostomia Management for Pediatric Oncology Patients with Lactoperoxidase Included Oral Health Care Products

Xerostomia Management for Pediatric Oncology Patients with Lactoperoxidase Included Oral Health Care Products

The dentin chemical degradation and saliva roles on Noncarious Cervical Lesions – literature review

Making sense of medieval mouths: Investigating sex differences of dental pathological lesions in a late medieval Italian community

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