Role of MRI in the Assessment of Cervical Cancer

Re, Giuseppe Lo; Cucinella, Giuseppe; Zaccaria, Giulia; Crapanzano, Agata; Salerno, Sergio; Pinto, Antonio; Casto, Antonio Lo; Chiàntera, Vito

doi:10.1053/j.sult.2023.03.010

Cited by 6 publications

(3 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The pre-treatment staging of cervical cancer is pivotal in determining the patient’s treatment trajectory, and MRI contributes to this planning [ 4 , 5 ]. Previously, the International Federation of Gynecology and Obstetrics (FIGO) 2009 staging was based solely on clinical examination and did not account for nodal status, which resulted in inaccuracies in advanced disease identified on imaging [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Systematic Review—Role of MRI in Cervical Cancer Staging

Chen,

Kitzing,

2024

Cancers

View full text Add to dashboard Cite

A systematic review of the diagnostic accuracy of MRI in the staging of cervical cancer was conducted based on the literature from the last 5 years. A literature search was performed in the Cochrane Library, EMBASE, MEDLINE and PubMed databases using the MeSH terms “cervical cancer”, “MRI” and “neoplasm staging”. A total of 110 studies were identified, of which 8 fit the inclusion criteria. MRI showed adequate accuracy (74–95%) and high sensitivity (92–100%) in assessing stromal invasion. The data for MRI in terms of assessing vaginal and pelvic side wall involvement were wide ranging and inconclusive. In assessing lymph node metastasis, MRI showed an adequate accuracy (73–90%), specificity (75–91%) and NPV (71–96%) but poor sensitivity (52–75%) and PPV (52–75%). MRI showed high accuracy (95%), sensitivity (78–96%), specificity (87–94%), and NPV (98–100%) but poor PPV (27–42%) in detecting bladder involvement. There was a paucity of data on the use of MRI in assessing rectal involvement in cervical cancer. Overall, the literature was heterogenous in the definitions and language used, which reduced the comparability between articles. More research is required into the diagnostic accuracy of MRI in the staging of cervical cancer and there must be increased consistency in the definitions and language used in the literature.

show abstract

Section: Introductionmentioning

confidence: 99%

Systematic Review—Role of MRI in Cervical Cancer Staging

Chen,

Kitzing,

2024

Cancers

View full text Add to dashboard Cite

show abstract

“…The ability to preoperatively gauge the LVSI status of a given patient is thus vital to support therapeutic decision-making, yet only postoperative pathological examinations can currently con rm the presence of LVSI. Magnetic resonance imaging (MRI) approaches are widely used to diagnose CC as they can provide a high level of soft tissue resolution, but conventional MRI scans are poorly suited to the assessment of patient LVSI status [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

An MRI radiomics-based model for the prediction of invasion of the lymphovascular space in patients with cervical cancer

Ma,

Wang,

2023

Preprint

View full text Add to dashboard Cite

Background Cervical cancer (CC) remains the second deadliest cancer-associated cause of mortality among women, and the ability to adequately predict the presence or absence of lymphovascular space invasion (LVSI) is vital to ensuring optimal patient outcomes. The objective of this study was to establish and verify an MRI radiomics-based model for the purpose of predicting the status of LVSI in patients with CC. Methods The present study conducted a retrospective analysis, wherein a total of 86 patients were included in the training cohort, and 38 patients were involved in the testing group, specifically focusing on patients with CC. The radiomics feature extraction process involved the utilization of ADC, T2WI-SPAIR, and T2WI sequences. Training group data were utilized for initial radionics-based model development, and model predictive performance was then validated based on data for patients enrolled in the experimental group. Results Radiomics scoring model construction was performed using 17 selected features. The study identified several risk variables associated with LVSI. These risk factors included elevated combined sequence-based radiomics scores (P < 0.001), more advanced FIGO staging (P = 0.03), cervical stromal invasion depth of a minimum of 1/2 (P = 0.02), and poorer tumor differentiation (P < 0.001). Radiomics scores based on combined sequences, ADC, T2WI-SPAIR, and T2WI exhibited AUCs of 0.931, 0.839, 0.815, 0.698, and 0.739 in the training cohort, respectively, with corresponding testing cohort values of 0.725, 0.692, 0.683, 0.833, and 0.854. The calibration curve analyses demonstrated an enhanced level of agreement between the actual and predicted LVSI status, indicating excellent consistency. Furthermore, the results of the decision curve study provided evidence for the clinical utility of this prediction model. Conclusions An MRI radiomics model was successfully developed and validated as a tool capable of predicting CC patient LVSI status, achieving high levels of overall diagnostic accuracy.

show abstract

“…Para-aortic lymph node involvement occurs in approximately 10-50% of LACC patients, and considering the limitations of imaging modalities, para-aortic surgical staging is also an option for these patients. However, this remains a controversial topic among gynecologic oncologists, and the clinical practice varies widely among different centers [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Urinary, Gastrointestinal, and Sexual Dysfunctions after Chemotherapy, Radiotherapy, Radical Surgery or Multimodal Treatment in Women with Locally Advanced Cervical Cancer: A Multicenter Retrospective Study

Di Donna,

Cucinella,

Giallombardo

et al. 2023

Cancers

Self Cite

View full text Add to dashboard Cite

Background: Different strategies have been proposed for the treatment of locally advanced cervical cancer (LACC), with different impacts on patient’s quality of life (QoL). This study aimed to analyze urinary, bowel, and sexual dysfunctions in a series of LACC patients who underwent chemotherapy, radiotherapy, radical surgery, or a combination of these treatments. Methods: Patients with LACC who underwent neoadjuvant radio–chemotherapy (NART/CT; n = 35), neoadjuvant chemotherapy (NACT; n = 17), exclusive radio–chemotherapy (ERT/CT; n = 28), or upfront surgery (UPS; n = 10) from November 2010 to September 2019 were identified from five oncological referral centers. A customized questionnaire was used for the valuation of urinary, gastrointestinal, and sexual dysfunctions. Results: A total of 90 patients were included. Increased urinary frequency (>8 times/day) was higher in ERT/CT compared with NACT/RT (57.1% vs. 28.6%; p = 0.02) and NACT (57.1% vs. 17.6%; p = 0.01). The use of sanitary pads for urinary leakage was higher in ERT/CT compared with NACT/RT (42.9% vs. 14.3%; p = 0.01) and NACT (42.9% vs. 11.8%; p = 0.03). The rate of reduced evacuations (<3 times a week) was less in UPS compared with NACT/RT (50% vs. 97.1%; p < 0.01), NACT (50% vs. 88.2, p < 0.01), and ERT/CT (50% vs. 96.4%; p < 0.01). A total of 52 women were not sexually active after therapy, and pain was the principal reason for the avoidance of sexual activity. Conclusions: The rate and severity of urinary, gastrointestinal, and sexual dysfunction were similar in the four groups of treatment. Nevertheless, ERT/CT was associated with worse sexual and urinary outcomes.

show abstract

Role of MRI in the Assessment of Cervical Cancer

Cited by 6 publications

References 38 publications

Systematic Review—Role of MRI in Cervical Cancer Staging

Systematic Review—Role of MRI in Cervical Cancer Staging

An MRI radiomics-based model for the prediction of invasion of the lymphovascular space in patients with cervical cancer

Urinary, Gastrointestinal, and Sexual Dysfunctions after Chemotherapy, Radiotherapy, Radical Surgery or Multimodal Treatment in Women with Locally Advanced Cervical Cancer: A Multicenter Retrospective Study

Contact Info

Product

Resources

About