Role of moxibustion in inflammatory responses during treatment of rat ulcerative colitis

Han, Yang; Ma, Tao; Lu, Maolin; Ren, Lu; Ma, Xiande; Bai, Zeng-Hua

doi:10.3748/wjg.v20.i32.11297

Cited by 26 publications

(11 citation statements)

References 35 publications

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“…The current study intends primarily to assess the effects of electroacupuncture and moxibustion in managing UC symptoms. Results have shown that both of these therapeutics can significantly improve the symptoms of UC as indicated by the measurement of DAI which is adopted in most clinical [ 25 ] and animal researches [ 26 ]. Further comparison has also indicated that both electroacupuncture and moxibustion may regulate the intestinal immune response mediated by rebalancing the Treg/Th17 axis [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…Wu et al [ 40 ] have suggested that moxibustion and acupuncture inhibited expression of inflammatory cytokines by observing IL-1 β and IL-6 mRNA expression in the spleen and colonic mucosa of UC rats. In Han's study [ 26 ], moxibustion treatment improves disease activity, repairs damaged colonic mucosa, and suppresses secretion of serum IL-8 while it activates that of IL-10, inhibits activation of NF- κ B p65, and decreases expression of TLR-9 in UC rats [ 26 ]. In our study, results indicate that both electroacupuncture and moxibustion treatment can improve disease activity, repair damaged colonic mucosa, decrease the protein expression of TLR2 and TLR4, increase the content of CD4+CD25+Foxp3+ Treg cells, and decrease the level of CD3+CD8+IL-17+Th17 cells.…”

Section: Discussionmentioning

confidence: 99%

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Regulating the Balance of Th17/Treg via Electroacupuncture and Moxibustion: An Ulcerative Colitis Mice Model Based Study

Sun

Zhang

Chengyulin

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Aim To investigate the relationship between the effects of electroacupuncture/moxibustion and the balance of Th17/Treg in treating ulcerative colitis (UC) and to preliminary compare the effects of the above two methods. Methods DSS-induced UC mice were treated by electroacupuncture and moxibustion. Disease activity index (DAI) was scored; intestinal pathological structure and ultrastructure were observed. The levels of IL-2, IL-6, IL-10, IL-17A, IL-17F, and TGF-β in plasma were measured by ELISA. The percentages of Treg and Th17 in spleen lymphocytes were analyzed by flow cytometry. Also, the expressions of TLR2, TLR4, RORγt, and FOXP3 in the distal colon were detected by immunohistochemistry or western blot. Results Both electroacupuncture and moxibustion can relieve UC. These effects are further supported by ELISA results. In addition, the ratio of Treg and Th17 in spleen lymphocytes and the expression of TLR2 and TLR4 are significantly improved. Also, the expression of RORγt and FOXP3 in distal colon were improved. Besides, the effect of moxibustion is better than that of electroacupuncture on TLR2, TLR4, and FOXP3 expression (P < 0.05). ConclusionBoth electroacupuncture and moxibustion may ameliorate UC by regulating the balance of Th17/Treg. Whether moxibustion has better efficacy than electroacupuncture needs further study.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Regulating the Balance of Th17/Treg via Electroacupuncture and Moxibustion: An Ulcerative Colitis Mice Model Based Study

Sun

Zhang

Chengyulin

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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“…The ancients believed that moxibustion can warm channels to dispel coldness, promote blood circulation to remove meridian obstruction, dissipate mass and relieve pain, compensate weakness and yang deficiency, and so forth [ 13 ]. Modern research has also shown that moxibustion can promote the metabolism of organisms, effectively improve the immunity and endocrine function of organisms, and treat systemic diseases involving circulation, digestion, respiration, immunity, and so forth [ 14 – 17 ]. With the development of science and technology, people have begun to study the mechanism of moxibustion from the standpoint of biology, chemistry, and physics [ 18 – 20 ].…”

Section: Introductionmentioning

confidence: 99%

Analysis of the Spectral Characteristics of Pure Moxa Stick Burning by Hyperspectral Imaging and Fourier Transform Infrared Spectroscopy

Song

Wang

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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The objective of this study was to investigate the spectra characteristics (SC) at wavelengths of 400~1000 nm and 2.5~15.5 μm of pure moxa stick (MS) during its 25-minute burning process using new spectral imaging techniques. Spectral images were collected for the burning pure MS at 5, 10, 15, 20, and 25 min using hyperspectral imaging (HSI) and Fourier transform infrared spectroscopy (FTIR) for the first time. The results showed that, at wavelengths of 400~1000 nm, the spectral range of the cross section of MS burning was 750~980 nm; the peak position was 860 nm. At wavelengths of 2.5~15.5 μm, the spectral range of the cross section of MS burning was 3.0~4.0 μm; the peak position was approximately 3.5 μm. The radiation spectra of MS burning include litter red and amount of infrared (but mainly near infrared) wavelengths. The temperature, blood perfusion, and oxygen saturation increase of Shenshu (BL23) after moxibustion radiation were observed too. According to mechanism of photobiological effects and moxibustion biological effects, it was inferred that moxibustion effects should be linked with moxibustion SC. This study provided new data and means for physical properties of moxibustion research.

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“…miRNAs play important roles in immune regulation in the colon. Acupuncture and moxibustion have immune regulatory and inflammation inhibition functions, and moxibustion can inhibit colitis in UC subjects [ 42 – 45 ]. The results in this study suggested that changes in miR-184 and miR-490-5p expression levels in colon tissues under the UC pathological status were reversed in the UCHM group.…”

Section: Discussionmentioning

confidence: 99%

Effects of Herb-Partitioned Moxibustion on the miRNA Expression Profiles in Colon from Rats with DSS-Induced Ulcerative Colitis

Huang

Dong

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Objective. This study explored the mechanism of herb-partitioned moxibustion (HM) on dextran sulfate sodium- (DSS-) induced ulcerative colitis (UC) from the miRNA perspective. Methods. Rats were randomly divided into 3 groups [normal control (NC) group, UC model (UC) group, and herb-partitioned moxibustion (UCHM) group]. The UC and UCHM groups were administered 4% DSS for 7 days. The UCHM group received HM at the Tianshu (bilateral, ST25). The effect of HM on UC was observed and the miRNA expression profile in the colon tissues was analyzed. Results. Compared with the UC group, the body weights were significantly higher in the UCHM group on day 14 (P < 0.001); the macroscopic colon injury scores and microscopic histopathology scores in the UCHM group decreased (P < 0.05); and there were 15 differentially expressed miRNAs in the UCHM group. The changes in miR-184 and miR-490-5p expression levels on the UC were reversed by HM intervention. Validation using qRT-PCR showed that two miRNAs expression trend was consistent with the sequencing results. Conclusion. HM at ST25 might regulate miR-184 and miR-490-5p expression, act on the transcription of their target genes to regulate inflammatory signaling pathways, and attenuate inflammation and tissue injury in the colons of rats with DSS-induced UC.

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Role of moxibustion in inflammatory responses during treatment of rat ulcerative colitis

Abstract: Moxibustion repairs damaged colonic mucosa, suppresses serum IL-8, activates serum IL-10 level, and decreases expression of TLR-9 and NF-κB p65 in UC rats.

Cited by 26 publications

References 35 publications

Regulating the Balance of Th17/Treg via Electroacupuncture and Moxibustion: An Ulcerative Colitis Mice Model Based Study

Regulating the Balance of Th17/Treg via Electroacupuncture and Moxibustion: An Ulcerative Colitis Mice Model Based Study

Analysis of the Spectral Characteristics of Pure Moxa Stick Burning by Hyperspectral Imaging and Fourier Transform Infrared Spectroscopy

Effects of Herb-Partitioned Moxibustion on the miRNA Expression Profiles in Colon from Rats with DSS-Induced Ulcerative Colitis

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