Role of molecular weight and hydrophobicity of amphiphilic tri-block copolymers in temperature-dependent co-micellization process and drug solubility

Lee, Chin-Fen; Yang, Ching-Hsun; Lin, Tsang–Lang; Bahadur, Pratap; Chen, Li‐Jen

doi:10.1016/j.colsurfb.2019.110461

Cited by 19 publications

(12 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was found that 0.2 wt % ibuprofen cannot be fully dissolved in 5 and 8 wt % F108 aqueous solutions. Thus, 0.1 wt % ibuprofen, around 50 times more than the solubility of ibuprofen in pure water at 37 °C, 9 was chosen and used in this study. The phase diagrams of the F108 aqueous solution in the presence of 0.1 wt % ibuprofen determined using HSDSC at 0.1 °C/min and rheological measurements at 10 °C/min are illustrated in Figure S4 in the Supporting Information.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Dynamic Behavior of the Structural Phase Transition of Hydrogel Formation Induced by Temperature Ramp and Addition of Ibuprofen

et al. 2020

Self Cite

View full text Add to dashboard Cite

Understanding the dynamic behavior of hydrogel formation induced by a temperature ramp is essential for the design of gel-based injectable formulation as drugdelivery vehicles. In this study, the dynamic behavior of the hydrogel formation of Pluronic F108 aqueous solutions within different heating rates was explored in both macroscopic and microscopic views. It was discovered that when the heating rate is increased, the gelation temperature window (hard gel region) shrinks and the mechanical strength of the hydrogel decreases. A given system at different heating rates would lead to different crystalline structural evolutions. The time-resolved small-angle X-ray scattering (SAXS) experiments at a heating rate of 10 °C/min disclose that the crystalline structure of micelle packing in the hydrogel exhibits a series of transitions: hexagonal close-packed (HCP) to face-centered cubic (FCC) and body-centered cubic (BCC) structures coexisting and then to the BCC structure along with the increasing temperature. For the system at equilibrium, the BCC structure exclusively dominates the system. Furthermore, the addition of a hydrophobic model drug (ibuprofen) to the F108 aqueous solution promotes hard gel formation at even lower temperatures and concentrations of F108. The SAXS results for the system with ibuprofen at a heating rate of 10 °C/min demonstrate a mixture of FCC and BCC structures coexisting over the whole gelation window compared to the BCC structure that exclusively dominates the system at equilibrium. The addition of ibuprofen would alter the structural evolution to change the delivery path of the encapsulated drug, which is significantly related to the performance of drug release.

show abstract

Section: ■ Results and Discussionmentioning

confidence: 99%

Dynamic Behavior of the Structural Phase Transition of Hydrogel Formation Induced by Temperature Ramp and Addition of Ibuprofen

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…[ 179 ] The temperature below which the surfactant remain as monomers is called critical micellization temperature (CMT). [ 180 ] The core of the self‐orienting micelles structure is lipophilic; hence, hydrophobic drugs and therapeutic agent can be loaded inside of the structure. In addition, hydrophobic surface ligand stabilized magnetic particles and hydrophobic drug‐loaded magnetic particles can also potentially be loaded inside the micelle structure for targeted therapeutic applications.…”

Section: Biomedical Applications Of Mnpsmentioning

confidence: 99%

Recent progress of magnetic nanoparticles in biomedical applications: A review

et al. 2021

View full text Add to dashboard Cite

Magnetic nanoparticles (MNPs) offer tremendous potentialities in biomedical applications for a long while. Since these materials' interactions in biological media largely rely on their crystal structures, sizes, and shapes, detailed studies on their synthesis mechanism for medicinal aspects are crucial. Despite many review reports that have already been published on MNPs, they mainly have focused either on their perspective in biomedical applications or their synthesis and characterization along with functionalization mechanisms as individual entities. For this reason, this review uncovers a comprehensive insight into the ongoing improvement of fabrication processes, surface functionalization of MNPs for biomedical applications together. Besides, various magnetic nanocomposite (MNCs) for smart drug delivery, recent hyperthermia treatment, lab‐on‐a‐chip, and magnetic bio‐separation, and some of the recent emerging imaging techniques using MNPs are discussed. A detailed analysis of toxicity, challenges, and recent progress of clinical trials of MNPs is sketched out to open numerous entryways for advanced research on MNPs for biomedical applications.

show abstract

“…These transitions primarily rely on temperature and additive existence or hydrophobicity and on copolymer concentration. Like electrolytes (inorganic salts, ionic liquids), nonelectrolytes (urea, sugar, alcohol), and amphiphilic compounds (hydrotropes and ionic surfactants with low molecular weight and other copolymers) additives [93][94][95][96][97]. The CMC or CMT is reduced by dehydration of PEO-PPO interface by additives with beneficial interactions with water.…”

Section: Modulation In Aggregation Behavior Of Pluronic Micellesmentioning

confidence: 99%

Functionalized Polymeric Nanoparticles: A Novel Targeted Approach for Oncology Care

Raikar

Dandagi

2021

Int J App Pharm

View full text Add to dashboard Cite

Popular cancer therapies face extreme disadvantages, including multimedicament tolerance and non-target impact. These issues will lead to poorer patient conformity and poor levels of survival. Successful medical therapies for cancer patients are desperately required. Nano-particulate structures with a pluronic base represent revolutionary platforms for anti-cancer agent provision. These structures provide great potential for the advancement of cancer therapy due to their pharmacological properties and sufficient physicochemical characteristics. This review aims to offer a more detailed description of the pluronic drug delivery mechani sms that are currently available and explains pluronic as a medicinal polymer. Hydrophobic payload formulations and updated, targeted distribution mechanisms are explained based on pluronic formulations. This analysis offers a rundown of the current situation art related to the theranostic application of polymer micelles targeting the microenvironment of cancer cells. Some guidelines for the future scope and possible opportunities are also been addressed. Search criteria: Primary sources such as Medline a principal component of PubMed, an online, searchable, and biomedical and life science research literature database has been used. It brings readers to almost any area of interest with research and journal articles. One of the internet resources of importance to get scientific publications is specialized scientific search engines known as Google Scholar a database of research material that can be searched for. I have used the online electronic access portal of Elsevier, such as Science Direct to its publications. Scopus is the biggest abstract and peer-reviewed literature database for scientific journals, books, and conference work. Keywords like Cancer, Pluronic, Nanoparticles, Chemotherapy, Cancer, Theranostic, Targeted, Micelles, and Core-shell are crucial as they notify search engines of the content of the site. Range of years: 1992-2020.

show abstract

Role of molecular weight and hydrophobicity of amphiphilic tri-block copolymers in temperature-dependent co-micellization process and drug solubility

Cited by 19 publications

References 36 publications

Dynamic Behavior of the Structural Phase Transition of Hydrogel Formation Induced by Temperature Ramp and Addition of Ibuprofen

Dynamic Behavior of the Structural Phase Transition of Hydrogel Formation Induced by Temperature Ramp and Addition of Ibuprofen

Recent progress of magnetic nanoparticles in biomedical applications: A review

Functionalized Polymeric Nanoparticles: A Novel Targeted Approach for Oncology Care

Contact Info

Product

Resources

About