Role of molecular and genetic factors in survival from uveal melanoma

Saakyan, S.V.; Tsygankov, Alexander Y.; Amiryan, A.G.; Sklyarova, N V; Zaletaev, D. V.

doi:10.17116/oftalma201613213-9

Cited by 3 publications

(3 citation statements)

References 17 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Меланома хориоидеи (МХ) является одной из самых злокачественных опухолей органа зрения, характеризуется возможностью развития метастазов и летального исхода в различные сроки от начала лечения [1][2][3][4][5][6]. Не вызывает сомнения, что ранняя диагностика опухоли, как и своевременное начало лечения определяют витальный прогноз.…”

unclassified

“…ОКТА , в основе которой лежит алгоритм декорреляционной амплитудной ангиографии с разделением спектра (split-spectrum amplitude decorrelation angiography -SSADA), дает возможность без введения красителя получать изображения микрососудистой сети с высоким разрешением, а также неинвазивно определять форму, калибр, структуру и локализацию новообразованных сосудов [17][18][19][20][21][22][23]. Значительное количество работ в офтальмоонкологии посвящено применению ОКТА для дифференциальной диагностики внутриглазных новообразований, A diagnostic assessment of angioarchitectonics of choroidal melanoma Irina E. Panova 1 , Elena V. Samkovich 1  , Pavel A. Nechiporenko 2 , Nyurguyana N. Grigoryeva 3,4 невусов и начальных меланом, а также для оценки постлучевых изменений заднего отдела глаза [24][25][26][27][28].…”

unclassified

See 1 more Smart Citation

A diagnostic assessment of angioarchitectonics of choroidal melanoma

Панова

Samkovich

Nechiporenko

et al. 2021

Rossijskij oftalʹmologičeskij žurnal

View full text Add to dashboard Cite

Purpose: to study angioarchitectonics of choroidal melanoma with varied biometric characteristics by comparing the results of indocyanine green angiography (IAG) and OCT angiography (OCTA).Material and methods. Angiography with indocyanine green and OCT angiography was performed in 45 choroidal melanoma patients (45 eyes, 20 men, 25 women, mean age 57.36 ± 15.11 years) to see the features of angioarchitectonics for various tumor elevations: up to 3 mm (small choroidal melanomas) and within the 3.1– 5.0 mm range (medium choroidal melanomas) and assess the informative value of the techniques.Results. We established a high diagnostic value of angiography with indocyanine green and OCT angiography in the diagnosis of vasculature of choroidal melanoma (89% and 71 %, respectively), an acceptable significance in small choroidal melanomas, and a higher informative value of angiography with indocyanine green in medium choroidal melanomas. The vasculature of small choroidal melanomas is characterized by type 1 angioarchitectonics predominance (59 %), while that of medium-sized melanomas corresponds to type 2 angioarchitectonics (81 %). The pattern match in angiography with indocyanine green and OCT angiography took place in 93.8 % of patients. The average depth of vessel identification during OCT angiography was determined to stay within the range of 186 μm for choroidal melanomas of up to 1.9 mm high, 220 μm for melanomas between 2 and 3 mm high, and 255 μm for melanomas higher than 3 mm.Conclusions. The use of contrast and non-contrast angiography in assessing the vasculature of choroidal melanoma is highly informative and useful for the assessment of the type of angioarchitectonics. The use of OCT angiography is more informative for tumors with an elevation of up to 3 mm. In order to increase the accuracy and effectiveness of OCTA, the identification of newly formed vessels should be carried out with regard to the parameters established.

show abstract

unclassified

A diagnostic assessment of angioarchitectonics of choroidal melanoma

Панова

Samkovich

Nechiporenko

et al. 2021

Rossijskij oftalʹmologičeskij žurnal

View full text Add to dashboard Cite

show abstract

“…Исследования последних десятилетий в области изучения молекулярно-генетических характеристик МХ свидетельствуют об ее значительных, отличных от меланомы кожи особенностях, что в определенной степени определяет характер ее биологического поведения, а именно более позднее метастазирование (в ряде случаев -спустя 10-15 и более лет) [11][12][13][14][15]. Несмотря на значимость проведения подобных исследований, в рутинной клинической практике важным является выделение группы риска больных МХ по метастазированию с учетом клинических, в ряде случаев -патоморфологических критериев.…”

unclassified

Determining the risk of metastasis of choroidal melanoma: clinical and instrumental criteria

Панова

Власова

Гюнтнер

et al. 2019

Rossijskij oftalʹmologičeskij žurnal

View full text Add to dashboard Cite

The purpose was to study the prevalence of metastasis of choroidal melanoma (CM) and clinical and instrumental criteria of the risk of such metastasis.Material and methods. A detailed analysis of clinical material for the period of 2000–2018 is presented, involving 304 patients with CM under continuous observation by an ophthalmic oncology center of a multidisciplinary cancer institution. Results. Metastatic lesion of various organs was diagnosed in 66 (21.7 %) patients. The average age of patients at the time of metastatic lesion verification was 55.65 ± 13.4 years, with the number of women patients prevailing (36 patients out of 66, or 54.5 %). Liver metastases were found in 63.6 %, lungs metastases, 4.5 %, multiple metastases — 31.9 % of patients. With regular follow-up, the critical period for metastasis detection was between one to five years — 77.2 % of patients with metastatic lesions and 16.8 % of the total number of the treated patients. The average time of metastasis appearance after the liquidation treatment was 27.75 ± 22.06 months, in cases of organ preservation treatment it was 61.57 ± 50.32 months. A metastatic process was diagnosed predominantly in large (63.6 %) and medium (28.8 %) CM. The risk criteria for metastatic development in CM were found to be: male gender, pre-equatorial localization, fungoid shape, large tumor size, pigmented tumor, transudative retinal detachment, mixed histopathological tumor variant.Conclusion. The established clinical and instrumental criteria of the risk of metastatic lesion in choroidal melanoma should be considered when planning follow-up monitoring of this group of patients.

show abstract