Role of MKP-1 (DUSP1) in clozapine-induced effects on the ERK1/2 signaling pathway in the rat frontal cortex

Kim, Se Hyun; Yu, Hyun Sook; Park, Hong Geun; Park, Soyoung; Seo, Mi Hae; Jeon, Wonjin; Ahn, Yong Min; Ha, Kyooseob; Shin, Soon Young; Kim, Yong Sik

doi:10.1007/s00213-013-3165-y

Cited by 8 publications

(2 citation statements)

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“…Clozapine also induces an initial increase followed by a decrease ERK1/2 phosphorylation 76). Interestingly, the dephosphorylation of ERK1/2 was shown to be mediated by mitogen-activated protein kinase phosphatases 1 (MKP1), which regulates ERK1/2 through direct binding 76). These results provided critical information on the dephosphorylation mechanism of MAPK in the typical and atypical antipsychotics.…”

Section: Main Subjectsmentioning

confidence: 91%

“…For example, a single injection of haloperidol has been to induce an acute increase followed by a decrease in mitogen-activated protein kinase kinas (MEK), ERK1/2, and p90 ribosomal S6 kinase (p90RSK) phosphorylation in the rat frontal cortex; this occurs without changes in Raf-1 phosphorylation, and these dephosphorylation of MEK and ERK1/2 were regulated by protein phosphatase 2A (PP2A) 75). Clozapine also induces an initial increase followed by a decrease ERK1/2 phosphorylation 76). Interestingly, the dephosphorylation of ERK1/2 was shown to be mediated by mitogen-activated protein kinase phosphatases 1 (MKP1), which regulates ERK1/2 through direct binding 76).…”

Section: Main Subjectsmentioning

confidence: 99%

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Potential Molecular and Cellular Mechanism of Psychotropic Drugs

Seo

Scarr

Lai

et al. 2014

Clin Psychopharmacol Neurosci

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Psychiatric disorders are among the most debilitating of all medical illnesses. Whilst there are drugs that can be used to treat these disorders, they give sub-optimal recovery in many people and a significant number of individuals do not respond to any treatments and remain treatment resistant. Surprisingly, the mechanism by which psychotropic drugs cause their therapeutic benefits remain unknown but likely involves the underlying molecular pathways affected by the drugs. Hence, in this review, we have focused on recent findings on the molecular mechanism affected by antipsychotic, mood stabilizing and antidepressant drugs at the levels of epigenetics, intracellular signalling cascades and microRNAs. We posit that understanding these important interactions will result in a better understanding of how these drugs act which in turn may aid in considering how to develop drugs with better efficacy or increased therapeutic reach.

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Section: Main Subjectsmentioning

confidence: 91%