Role of Mitomycin-C in Prevention of Post Operative Adhesions After Endoscopic Sinus Surgery––A Prospective Study

Abstract

To evaluate the role of Mitomycin-C in preventing synaechiae formation and ostial stenosis following endoscopic sinus surgery. This prospective study was conducted in VMMC and Safdarjung hospital from

Efficacy of Mitomycin C for postoperative endoscopic sinus surgery: a systematic review and meta‐analysis

“…polypoid mucosa, granulation tissue, crusting and discharge, and mucosal hypertrophy) were also reported. Clinical symptoms were also reported in some studies; these included recurrent symptoms of rhinosinusitis, nasal obstruction, nasal discharge and hyposmia . A saccharin test was reported by only one study …”

“…Characteristics of the included studies are described in Table . Among 11 trials, 10 were paired designs, in which each patient received two treatments (bilateral sinusitis) and only one trial was a parallel RCT (unilateral sinusitis). Most trials had a percentage of male patients ranged from 47% to 70%.…”

“…Mitomycin C or saline solution was applied after endoscopic sinus surgery. The concentrations of Mitomycin C used were 0.4, 0.45, 0.5, 0.8, and 1.0 mg/mL with a volume of 1, 1.5, and 5 mL . The application time ranged from 4 to 5 min.…”

“…Recently, Mitomycin C has been used in endoscopic sinus surgery, and some studies have found a benefit in prevention of scar formation whereas other studies did not . The treatment effects across these studies were relatively imprecise because of small sample size.…”

Efficacy of Mitomycin-C for Prevention of Adhesion Formation after Functional Endoscopic Sinus Surgery in Cases of Chronic Rhinosinusitis: A Prospective Cross-sectional Study

“…1,2 Functional endoscopic sinus surgery (FESS)/endoscopic sinus surgery (ESS) as described by Messerklinger has been accepted as the choice of treatment modality for chronic sinus disease. 3 Though there are advances in instrumentation and surgical technique, postoperative adhesions, synechiae formation continue to occur between 1 and 27%. 4 The incidence of adhesions requiring surgical intervention is 1 to 2%.…”