Role of mitochondrial peroxidation of lipids in their hydrolysis by endogenous phospholipase A2

Marzoev, A. I.; Mirtalipov, D T; Almatov, K T

doi:10.1007/bf00841894

Cited by 1 publication

(1 citation statement)

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“…It has been demonstrated that ROS production could activate phospholipases (van Rossum et al, 2004). This activating effect has been shown for different form of ROS including the product of oxidative stresslipid peroxidation (Hermann et al, 2014;Marzoev et al, 1987;Timusheva et al, 1998). Lipid peroxidation is affecting different isoforms of phospholipase A in mitochondria, cytosol and lysosomes.…”

Section: Mitochondrial Ros As Activators Of Phospholipasesmentioning

confidence: 96%

Functional role of mitochondrial reactive oxygen species in physiology

Angelova

Abramov

2016

Free Radical Biology and Medicine

210

169

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Emails: p. stroh@ucl.ac.uk or a.abramov@ucl.ac.uk ABSTRACT The major energy generator in the cell -mitochondria produce reactive oxygen species as a by-product of a number of enzymatic reactions and ATP production. Emerging evidence suggests that mitochondrial ROS regulate diverse physiological parameters and that dysregulated ROS signalling may contribute to a development of pathologies which leads to human diseases. ROS produced in mitochondrial enzymes are trigger for monoamine-induced calcium signal in astrocytes, playing important role in physiological and pathophysiological response to dopamine. Generation of ROS in mitochondria leads to peroxidation of lipids, which is considered to be one of the most important mechanisms of cell injury under condition of oxidative stress. However, it also can induce activation of mitochondrial and cellular phospholipases that can trigger variety of the signals -from activation of ion channels to stimulation of calcium signal. Mitochondria are shown to be the oxygen sensor in astrocytes, therefore inhibition of respiration by hypoxia induces ROS production which leads to lipid peroxidation, activation of phospholipase C and induction of IP3-mediated calcium signal. Propagation of astrocytic calcium signal stimulates breathing activity in response to hypoxia. Thus, ROS produced in mitochondrial enzymes or electron transport chain can be used as a trigger for signalling cascades in central nervous system and deregulation of this process leads to pathology.

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Section: Mitochondrial Ros As Activators Of Phospholipasesmentioning

confidence: 96%