Role of miRs in immune suppression

Seliger, Barbara; Jasinski‐Bergner, Simon; Gonschorek, Evamaria; Teren, M.; Stoehr, Christine; Meinhardt, Anne; Stehle, Franziska; Schulz, Kristin; Wullich, Bernd; Hartmann, Arndt

doi:10.1186/2051-1426-2-s3-p268

Cited by 1 publication

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“…MiRNAs play a crucial role as clinical biomarkers in cancer, exerting an impact on prognosis, diagnosis, and treatment responses. These entities demonstrate substantial influence as oncogenes and tumor suppressors, which affects conventional treatments and immune reactions within the tumor microenvironment (TME) ( Seliger et al, 2014 ). The utilisation of therapeutics that target miRNAs exhibits potential for enhancing immunotherapy in combination with established treatments.…”

Section: Mirna and Cancer Immune Evasionmentioning

confidence: 99%

Mapping the function of MicroRNAs as a critical regulator of tumor-immune cell communication in breast cancer and potential treatment strategies

Abdul Manap,

Wisham,

Wong

et al. 2024

Front. Cell Dev. Biol.

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Among women, breast cancer ranks as the most prevalent form of cancer, and the presence of metastases significantly reduces prognosis and diminishes overall survival rates. Gaining insights into the biological mechanisms governing the conversion of cancer cells, their subsequent spread to other areas of the body, and the immune system’s monitoring of tumor growth will contribute to the advancement of more efficient and targeted therapies. MicroRNAs (miRNAs) play a critical role in the interaction between tumor cells and immune cells, facilitating tumor cells’ evasion of the immune system and promoting cancer progression. Additionally, miRNAs also influence metastasis formation, including the establishment of metastatic sites and the transformation of tumor cells into migratory phenotypes. Specifically, dysregulated expression of these genes has been associated with abnormal expression of oncogenes and tumor suppressor genes, thereby facilitating tumor development. This study aims to provide a concise overview of the significance and function of miRNAs in breast cancer, focusing on their involvement as tumor suppressors in the antitumor immune response and as oncogenes in metastasis formation. Furthermore, miRNAs hold tremendous potential as targets for gene therapy due to their ability to modulate specific pathways that can either promote or suppress carcinogenesis. This perspective highlights the latest strategies developed for miRNA-based therapies.

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Section: Mirna and Cancer Immune Evasionmentioning

confidence: 99%