Role of miRNAs in melanin metabolism: Implications in melanin‐related diseases

Zhang, Zhigang; Shen, Wanlu; Liu, Weimin; Lyu, Lechun

doi:10.1111/jocd.14762

Cited by 5 publications

(4 citation statements)

References 97 publications

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“…In contrast to our results, Dong et al found overexpression of miR-137 in their study that targets c-KIT in melanocytes 73 . Overexpression of miR-137 may reduce the expression of Tyrosinase Related Protein 2 (TYRP2) and c-KIT and reduce the increase in melanin production caused by ultraviolet (UV) treatment 74 . It is suggested that miR-137 can inhibit melanogenesis in mouse skin melanocytes by inhibiting the expression of c-KIT and TYRP2 in the SCF/c-KIT signaling pathway 75 .…”

Section: Discussionmentioning

confidence: 99%

Investigating melanogenesis-related microRNAs as disease biomarkers in vitiligo

Abdallah

Abdelhamid

Mohammed

et al. 2022

Sci Rep

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Vitiligo is considered a disabling disease that affects physical, social, psychological, and occupational aspects of an individual's quality of life. The search for non-invasive and reliable biomarkers for vitiligo's early diagnosis, prognosis, and treatment prediction is under intensive investigation. There is currently an emerging interest in employing miRNAs as biomarkers to predict vitiligo diagnosis and prognosis, inspired by the well-preserved nature of miRNAs in serum or plasma. In the current study, we assessed a panel of 20 melanogenesis pathway-related microRNAs (miRNAs) using quantitative real-time PCR technique in 85 non-segmental vitiligo (NSV) patients compared to 85 normal controls followed by function and pathway enrichment analysis for the miRNAs with significant results. Twelve out of the 20 circulating miRNAs showed significantly higher expression levels in vitiligo patients relative to controls where miR-423 show the highest expression level followed by miR-182, miR-106a, miR-23b, miR-9, miR-124, miR-130a, miR-203a, miR-181, miR-152, and miR-320a. While six miRNAs (miR-224, miR-148a, miR-137, and miR-7, miR-148b, miR-145, miR-374b, and miR-196b) didn’t show significant expression level. The analysis of the receiver operating curve indicated that miR-423, miR-106a, and miR-182 were outstanding biomarkers with the highest areas under the curve in vitiligo. This study is the first Egyptian study to investigate a panel of miRNAs expression profile in the plasma of patients with NSV. Our results suggest that specific circulating miRNAs signature might be implicated in vitiligo pathogenesis and could potentially be used as biomarkers in vitiligo.

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Section: Discussionmentioning

confidence: 99%

Investigating melanogenesis-related microRNAs as disease biomarkers in vitiligo

Abdallah

Abdelhamid

Mohammed

et al. 2022

Sci Rep

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“…Melanogenesis is the name of the process that produces different types of melanin [ 1 , 2 ]. Although melanin protects skin from the harmful effects of ultraviolet radiation, overproduction results in unwanted complications in the skin, such as freckles, lesions, and discoloration, to name few [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Quercetin 3-O-Galactoside Isolated from Limonium tetragonum Inhibits Melanogenesis by Regulating PKA/MITF Signaling and ERK Activation

Karadeniz

Seo

et al. 2023

IJMS

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Quercetin 3-O-galactoside (Q3G) is a common dietary flavanol that has been shown to possess several bioactivities, including anti-melanogenesis. However, how Q3G exerts its anti-melanogenic effect has not been studied. The current study, therefore aimed to investigate the anti-melanogenesis potential of Q3G and elucidate the underlying action mechanism in α-melanocyte-stimulating hormone (α-MSH)-induced hyperpigmentation model of B16F10 murine melanoma cells. Results showed that α-MSH stimulation significantly increased tyrosinase (TYR) and melanin production, which were significantly downregulated by Q3G treatment. The treatment with Q3G suppressed the transcriptional and protein expressions of melanogenesis-related enzymes TYR, tyrosinase related protein-1 (TRP-1), and TRP-2, along with the melanogenic transcription factor microphthalmia-associated transcription factor (MITF) in B16F10 cells. It was shown that Q3G downregulated MITF expression and suppressed its transcriptional activity by inhibiting the cAMP-dependent protein kinase A (PKA)-mediated activation of CREB and GSK3β. In addition, MAPK-regulated MITF activation signaling was also involved in the inhibition of melanin production by Q3G. The results suggest that the anti-melanogenic properties of Q3G rationalize further studies in vivo to confirm its action mechanism and consequent utilization as a cosmetic ingredient against hyperpigmentation.

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“…Cao et al (2020) analyzed the pathogenic factors and pathogenesis of chloasma from the perspective of traditional Chinese medicine and western medicine, providing theoretical basis for the treatment of chloasma. Zhang et al (2022) discussed the effect and mechanism of miRNA, and analyzed the significance of miRNA in the pathogenesis of chloasma. Chen et al (2020) treated chloasma with Bletilla striata polysaccharide cream and Honghua Xiaoyao tablets.…”

Section: Introductionmentioning

confidence: 99%

TGF-β Mediates the Role of P53 and microRNA-Related Signaling Pathways in the Pathogenesis of Diabetic Nephropathy in Rats

Ma¹

2023

PJZ

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The objective of this study was to discuss the effect of Beauty and Freckle Removing Soup (BFRS) combined with reduced glutathione on oxidative stress (OS) and disease-related factors in patients with chloasma. Patients with chloasma were selected in West Anhui Health Vocational College between January 2021 and June 2022. Eighty patients were randomly separated into a combination group (Group J) and glutathione group (Group G). Patients in the Group G were treated with reduced glutathione. For patients in the Group J, on the basis of Group G, they were treated with BFRS. After a 2-month treatment, the scores of TCM symptoms, chloasma area, total score of skin lesions, loss of trans epidermal water shunt, MDA level, SIL-2, TNF-α, MSH and DLQI in group J were remarkably lower than group G. The skin cuticle water content, SOD level, and GSH-Px level were remarkably superior to those of group G. It was concluded that BFRS combined with reduced glutathione performs excellent on treating chloasma, which is able to enhance the status of patients with chloasma significantly.

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Role of miRNAs in melanin metabolism: Implications in melanin‐related diseases

Cited by 5 publications

References 97 publications

Investigating melanogenesis-related microRNAs as disease biomarkers in vitiligo

Investigating melanogenesis-related microRNAs as disease biomarkers in vitiligo

Quercetin 3-O-Galactoside Isolated from Limonium tetragonum Inhibits Melanogenesis by Regulating PKA/MITF Signaling and ERK Activation

TGF-β Mediates the Role of P53 and microRNA-Related Signaling Pathways in the Pathogenesis of Diabetic Nephropathy in Rats

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