Role of miRNAs in Coronary Artery Disease

Xie, Leixing; Du, Ronghui; Niu, Jingxue; Liu, Hongbin

doi:10.2174/1574362410666141224210818

Cited by 1 publication

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“…Over the past decade, miR-1 and miR-21 have been some of the most frequently studied miRNAs in the CVD area, especially in the CAD, acute coronary syndrome and HF field [ 105 , 106 ]. Evaluations revealed that these molecules are confirmed to impact signaling pathways involved in atherosclerosis, hypertrophy, myocardial remodeling and fibrosis [ 107 ].…”

Section: The Essential Role Of Mirnas In the Regulation Of Dcm Pathogmentioning

confidence: 99%

MicroRNAs and long non-coding RNAs in the pathophysiological processes of diabetic cardiomyopathy: emerging biomarkers and potential therapeutics

Jakubik

Fitas

Eyileten

et al. 2021

Cardiovasc Diabetol

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The epidemic of diabetes mellitus (DM) necessitates the development of novel therapeutic and preventative strategies to attenuate complications of this debilitating disease. Diabetic cardiomyopathy (DCM) is a frequent disorder affecting individuals diagnosed with DM characterized by left ventricular hypertrophy, diastolic and systolic dysfunction and myocardial fibrosis in the absence of other heart diseases. Progression of DCM is associated with impaired cardiac insulin metabolic signaling, increased oxidative stress, impaired mitochondrial and cardiomyocyte calcium metabolism, and inflammation. Various non-coding RNAs, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), as well as their target genes are implicated in the complex pathophysiology of DCM. It has been demonstrated that miRNAs and lncRNAs play an important role in maintaining homeostasis through regulation of multiple genes, thus they attract substantial scientific interest as biomarkers for diagnosis, prognosis and as a potential therapeutic strategy in DM complications. This article will review the different miRNAs and lncRNA studied in the context of DM, including type 1 and type 2 diabetes and the contribution of pathophysiological mechanisms including inflammatory response, oxidative stress, apoptosis, hypertrophy and fibrosis to the development of DCM .

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Section: The Essential Role Of Mirnas In the Regulation Of Dcm Pathogmentioning

confidence: 99%