Role of miRNA in head and neck squamous cell carcinoma

Masood, Yaghma; Kqueen, Cheah Yoke; Rajadurai, Pathmanathan

doi:10.1586/14737140.2015.978294

Cited by 22 publications

(18 citation statements)

References 129 publications

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“…Several recent studies have shown differential miRNA expression in HNSCC (Jamali et al., ; Koshizuka et al., ; Masood, Kqueen, & Rajadurai, ). Barker et al.…”

Section: Introductionmentioning

confidence: 99%

“…Decreased expression of hsa‐miR‐200b‐5p and hsa‐miR‐29c‐3p in tumor was found to be associated with higher tumor grade, and decreased expression of hsa‐miR‐29c‐3p in adjacent tumor tissue was associated with worse survival and with worse relapse‐free survival. These miRNA profiles were found to correlate with disease etiology, pathogenesis, metastasis, and recurrence of HNSCC (Barker et al., ; Chen et al., ; Hui et al., ; Masood et al., ). Thus, studies till date suggest distinct miRNA profiles may have potential as diagnostic and prognostic markers in HNSCC but these observations still need to be validated in larger cohorts and in different ethnic populations.…”

Section: Introductionmentioning

confidence: 99%

“…miR‐21 was the first miRNA to be termed an “oncomiR” and was found to be overexpressed in several different cancer types. Till date, several other oncogenic miRNAs have been identified including miR‐155, miR‐106b‐25, miR‐130b, miR‐16, miR‐184, miR‐210, miR‐211, miR‐35b, miR‐221, miR‐222, and miR‐1297 (Chang, Jiang et al., ; Chen et al., ; Masood et al., ). In a recent study, aggressive tumors were found to have higher levels of let‐7c, miR‐130a‐3p, miR‐361‐5p, miR‐99a‐5p, miR‐29c‐3p, and let‐7d‐5p as compared to non‐aggressive tumors in OSCC suggesting their pro‐oncogenic role (Hilly et al., ).…”

Section: Introductionmentioning

confidence: 99%

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Role of non‐coding RNAs in head and neck squamous cell carcinoma: A narrative review

et al. 2017

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Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide with high recurrence, metastasis, and poor treatment outcome. Recent studies have reported that non-coding RNA (ncRNA) might play critical role in regulating different types of cancer. MicroRNAs (miRs) are short ncRNAs (20-25 nucleotides) responsible for post-transcriptional regulation of gene expression and may have a role in oncogenesis by acting as oncomiRs or tumor suppressor miRs. Long non-coding RNAs (lncRNAs) are heterogenous group of ncRNAs more than 200 nucleotides long, can act in cis and/or in trans, and have been also implicated in carcinogenesis. These molecules have been suggested to be promising candidates as diagnostic and prognostic biomarkers and for development of novel therapeutic approaches. In this review, we have summarized recent findings on role of these ncRNAs in HPV-negative (HPV-ve) and HPV-positive (HPV+ve) HNSCC. The available literature supports differential expression of both microRNAs and long non-coding RNAs, which include oncogenic ncRNAs (miR-21, miR-31, miR-155, miR-211, HOTAIR, and MALAT1) and tumor suppressor ncRNAs (let7d, miR-17, miR-375, miR-139, and MEG3) in HPV+ve HNSCC tumors as compared to HPV-ve tumors and they have distinct role in the pathophysiology of these two types of HNSCCs.

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“…Several recent studies have shown differential miRNA expression in HNSCC (Jamali et al., ; Koshizuka et al., ; Masood, Kqueen, & Rajadurai, ). Barker et al.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Role of non‐coding RNAs in head and neck squamous cell carcinoma: A narrative review

et al. 2017

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“…These are noncoding RNAs derived from loci in the homeobox (HOX) gene clusters 21 in human chromosomes 17q21.32 (MIR196A1), 12q13.13 (MIR196A2) and 7p15.2 (MIR196B), among which the mature microRNAs miR-196a1 and a2 are identical and miR-196b differs by one nucleotide. As individual microRNAs can regulate multiple genes 17, 18 including those encoding transcription factors, we also investigated the potential contribution of transcriptional control by analysis of ANXA1 promoter activity.…”

Section: Introductionmentioning

confidence: 99%

Annexin A1 down-regulation in head and neck squamous cell carcinoma is mediated via transcriptional control with direct involvement of miR-196a/b

Álvarez-Teijeiro

Menéndez

Villaronga

et al. 2017

Sci Rep

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Annexin A1 (ANXA1) down-regulation is an early and frequent event in the development of head and neck squamous cell carcinomas (HNSCC). In an attempt to identify the underlying mechanisms of reduced ANXA1 protein expression, this study investigated ANXA1 mRNA expression in HNSCC specimens by both in situ hybridization and RT-qPCR. Results showed a perfect concordance between the pattern of ANXA1 mRNA and protein detected by immunofluorescence in tumors, precancerous lesions and normal epithelia, reflecting that ANXA1 down-regulation occurs at transcriptional level. We also found that both miR-196a and miR-196b levels inversely correlated with ANXA1 mRNA levels in paired HNSCC tissue samples and patient-matched normal mucosa. In addition, endogenous levels of ANXA1 mRNA and protein were consistently and significantly down-regulated upon miR-196a and miR-196b over-expression in various HNSCC-derived cell lines. The direct interaction of both mature miR-196a and miR-196b was further confirmed by transfection with Anxa1 3′UTR constructs. Combined bioinformatics and functional analysis of ANXA1 promoter activity contributed to identify key regions and potential mediators of ANXA1 transcriptional control. This study unveils that, in addition to miR-196a, miR-196b also directly targets ANXA1 in HNSCC.

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“…11 According to several studies miRNAs expression profile is also emerging among the best markers for diagnosis, staging, and treatment of cancer, including head and neck squamous cell carcinoma. [12][13][14] In particular, our group together with others has observed a correlation between the expression of specific miRNAs and outcome of head and neck squamous cell carcinoma patients. 12,[14][15][16] Here, we aimed at identifying key alterations of miRNAs expression occurring in tumor-surrounding mucosa (referred to as 'peritumoral' mucosa hereafter) from head and neck squamous cell carcinoma patients, which predict local recurrence.…”

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confidence: 99%

Altered peritumoral microRNA expression predicts head and neck cancer patients with a high risk of recurrence

Ganci¹,

Sacconi²,

Manciocco³

et al. 2017

Modern Pathology

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Head and neck squamous cell carcinoma is typically characterized by a high incidence of local recurrences. It has been extensively shown that mucosa from head and neck squamous cell carcinoma patients carries both genetic and gene expression alterations, which are mostly attributable to major etiologic agents of head and neck squamous cell carcinoma. We previously identified a signature of microRNAs (miRNAs) whose high expression in tumors is predictive of recurrence. Here, we investigated whether the deregulation of miRNA expression in the tumor-surrounding mucosa is correlated to disease recurrence. Specifically, comparing the miRNA expression in matched tumoral, peritumoral, and normal tissues collected from head and neck squamous cell carcinoma patients, we identified 35 miRNAs that are deregulated in both tumoral and peritumoral tissues as compared with normal matched samples. Four of these composed a miRNA signature that predicts head and neck squamous cell carcinoma local recurrence independently from prognostic clinical variables. The predictive power of the miRNA signature increased when using the expression levels derived from both the peritumoral and the tumoral tissues. The expression signal of the miRNAs composing the predictive signature correlated with the transcriptional levels of genes mostly associated with proliferation. Our results show that expression of miRNAs in tumor-surrounding mucosa may strongly contribute to the identification of head and neck squamous cell carcinoma patients at high risk of local recurrence.

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Role of miRNA in head and neck squamous cell carcinoma

Cited by 22 publications

References 129 publications

Role of non‐coding RNAs in head and neck squamous cell carcinoma: A narrative review

Role of non‐coding RNAs in head and neck squamous cell carcinoma: A narrative review

Annexin A1 down-regulation in head and neck squamous cell carcinoma is mediated via transcriptional control with direct involvement of miR-196a/b

Altered peritumoral microRNA expression predicts head and neck cancer patients with a high risk of recurrence

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