Role of microvascular dysfunction in left ventricular dysfunction in type 2 diabetes mellitus

Halabi, Amera; Nolan, Mark; Potter, Elizabeth; Wright, Leah; Asham, Atef; Marwick, Thomas H.

doi:10.1016/j.jdiacomp.2021.107907

Cited by 4 publications

(3 citation statements)

References 42 publications

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“…Therefore, a total of 67 independent populations were included. Among the 47 studies, 22 were from Japan [ 19 – 21 , 23 – 37 , 42 , 44 , 45 , 47 ], eight from the United States [ 7 , 14 , 22 , 40 , 41 , 48 , 51 , 55 ], five from Sweden [ 12 , 16 , 17 , 53 , 54 ], three from Germany and Sweden [ 11 , 15 , 46 ], two from Finland [ 38 , 39 ], and one each from Australia [ 18 ], France [ 43 ], Italy [ 9 ], Norway [ 13 ], Turkey [ 10 ], the United Kingdom [ 49 ], Switzerland [ 7 ], and the Netherlands [ 50 ]. Year of publication ranged from 1992 to 2022.…”

Section: Resultsmentioning

confidence: 99%

“…Year of publication ranged from 1992 to 2022. In 35 studies, 1.5T CMR systems were used [ 7 , 9 – 12 , 15 – 17 , 19 – 21 , 24 – 32 , 34 – 40 , 42 , 46 – 49 , 51 , 52 , 54 ]; in nine studies, 3T CMR systems were used [ 13 , 14 , 18 , 22 , 33 , 41 , 43 , 53 , 55 ]; in one study, both 1.5 and 3T CMR units were used [ 44 ]; and in one study, a 0.6T CMR system was used [ 50 ]. Information on pharmacological stress was extracted from 41 studies.…”

Section: Resultsmentioning

confidence: 99%

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Coronary flow reserve evaluated by phase-contrast cine cardiovascular magnetic resonance imaging of coronary sinus: a meta-analysis

Tanigaki

Kato

Azuma

et al. 2023

Journal of Cardiovascular Magnetic Resonance

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Background Phase-contrast cine cardiovascular magnetic resonance (CMR) of the coronary sinus has emerged as a non-invasive method for measuring coronary sinus blood flow and coronary flow reserve (CFR). However, its clinical utility has not yet been established. Here we performed a meta-analysis to clarify the clinical value of CMR-derived CFR in various cardiovascular diseases. Methods An electronic database search was performed of PubMed, Web of Science Core Collection, Cochrane Advanced Search, and EMBASE. We compared the CMR-derived CFR of various cardiovascular diseases (stable coronary artery disease [CAD], hypertrophic cardiomyopathy [HCM], dilated cardiomyopathy [DCM]) and control subjects. We assessed the prognostic value of CMR-derived CFR for predicting major adverse cardiac events (MACE) in patients with stable CAD. Results A total of 47 eligible studies were identified. The pooled CFR from our meta-analysis was 3.48 (95% confidence interval [CI], 2.98–3.98) in control subjects, 2.50 (95% CI, 2.38–2.61) in stable CAD, 2.01 (95% CI, 1.70–2.32) in cardiomyopathies (HCM and DCM). The meta-analysis showed that CFR was significantly reduced in stable CAD (mean difference [MD] = −1.48; 95% CI, −1.78 to −1.17; p < 0.001; I2 = 0%; p for heterogeneity = 0.33), HCM (MD = −1.20; 95% CI, −1.63 to −0.77; p < 0.001; I2 = 0%; p for heterogeneity = 0.49), and DCM (MD = −1.53; 95% CI, −1.93 to −1.13; p < 0.001; I2 = 0%; p for heterogeneity = 0.45). CMR-derived CFR was an independent predictor of MACE for patients with stable CAD (hazard ratio = 0.52 per unit increase; 95% CI, 0.37–0.73; p < 0.001; I2 = 84%, p for heterogeneity < 0.001). Conclusions CMR-derived CFR was significantly decreased in cardiovascular diseases, and a decreased CFR was associated with a higher occurrence of MACE in patients with stable CAD. These results suggest that CMR-derived CFR has potential for the pathological evaluation of stable CAD, cardiomyopathy, and risk stratification in CAD.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Coronary flow reserve evaluated by phase-contrast cine cardiovascular magnetic resonance imaging of coronary sinus: a meta-analysis

Tanigaki

Kato

Azuma

et al. 2023

Journal of Cardiovascular Magnetic Resonance

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“…Obesity frequently coexists with type 2 diabetes and has an additive detrimental effect on diastolic function ( 18 ). Although diastolic dysfunction has been linked to such processes as myocardial fibrosis, myocardial triglyceride accumulation and insulin resistance, echocardiographic features of diastolic dysfunction have been also attributable to coronary microvascular dysfunction ( 19 ).…”

Section: The Role Of Echocardiography In the Diagnosis Of Diabetic Ca...mentioning

confidence: 99%

Multi-modality cardiac imaging in the management of diabetic heart disease

Wamil

Gonçalves²,

Rutherford

et al. 2022

Front. Cardiovasc. Med.

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Diabetic heart disease is a major healthcare problem. Patients with diabetes show an excess of death from cardiovascular causes, twice as high as the general population and those with diabetes type 1 and longer duration of the disease present with more severe cardiovascular complications. Premature coronary artery disease and heart failure are leading causes of morbidity and reduced life expectancy. Multimodality cardiac imaging, including echocardiography, cardiac computed tomography, nuclear medicine, and cardiac magnetic resonance play crucial role in the diagnosis and management of different pathologies included in the definition of diabetic heart disease. In this review we summarise the utility of multi-modality cardiac imaging in characterising ischaemic and non-ischaemic causes of diabetic heart disease and give an overview of the current clinical practice. We also describe emerging imaging techniques enabling early detection of coronary artery inflammation and the non-invasive characterisation of the atherosclerotic plaque disease. Furthermore, we discuss the role of MRI-derived techniques in studying altered myocardial metabolism linking diabetes with the development of diabetic cardiomyopathy. Finally, we discuss recent data regarding the use of artificial intelligence applied to large imaging databases and how those efforts can be utilised in the future in screening of patients with diabetes for early signs of disease.

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Editorial for “Coronary Microvascular Dysfunction and Diffuse Myocardial Fibrosis in Patients with Type 2 Diabetes Using Quantitative Perfusion MRI”

Bernard,

Kober

2024

Magnetic Resonance Imaging

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Role of microvascular dysfunction in left ventricular dysfunction in type 2 diabetes mellitus

Cited by 4 publications

References 42 publications

Coronary flow reserve evaluated by phase-contrast cine cardiovascular magnetic resonance imaging of coronary sinus: a meta-analysis

Coronary flow reserve evaluated by phase-contrast cine cardiovascular magnetic resonance imaging of coronary sinus: a meta-analysis

Multi-modality cardiac imaging in the management of diabetic heart disease

Editorial for “Coronary Microvascular Dysfunction and Diffuse Myocardial Fibrosis in Patients with Type 2 Diabetes Using Quantitative Perfusion MRI”

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