Role of microRNA in diabetic cardiomyopathy: From mechanism to intervention

Guo, Rui; Nair, Sreejayan

doi:10.1016/j.bbadis.2017.03.013

Cited by 79 publications

(65 citation statements)

References 123 publications

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“…For example, miRNA-21 augments pathological cardiac remodelling by stimulating MAP kinase signalling in fibroblasts [192]. Similarly, miRNAs are differentially regulated in diabetic hearts [85, 126, 178]. One example is miRNA-223, which is upregulated in LV biopsies from T2D patients and regulates GLUT4 expression and glucose uptake [126].…”

Section: Mechanisms Contributing To Myocardial Dysfunction In Diabetimentioning

confidence: 99%

“…One example is miRNA-223, which is upregulated in LV biopsies from T2D patients and regulates GLUT4 expression and glucose uptake [126]. As previously reviewed, miRNA expression is altered in rodent models of T1D and T2D [85, 176]. One example of this has been observed in T2D ZDF rats, in which dysregulated miRNA-29 expression is correlated with cardiac structural damage [8].…”

Section: Mechanisms Contributing To Myocardial Dysfunction In Diabetimentioning

confidence: 99%

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Of mice and men: models and mechanisms of diabetic cardiomyopathy

2018

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Diabetes mellitus increases the risk of heart failure independent of co-existing hypertension and coronary artery disease. Although several molecular mechanisms for the development of diabetic cardiomyopathy have been identified, they are incompletely understood. The pathomechanisms are multifactorial and as a consequence, no causative treatment exists at this time to modulate or reverse the molecular changes contributing to accelerated cardiac dysfunction in diabetic patients. Numerous animal models have been generated, which serve as powerful tools to study the impact of type 1 and type 2 diabetes on the heart. Despite specific limitations of the models generated, they mimic various perturbations observed in the diabetic myocardium and continue to provide important mechanistic insight into the pathogenesis underlying diabetic cardiomyopathy. This article reviews recent studies in both diabetic patients and in these animal models, and discusses novel hypotheses to delineate the increased incidence of heart failure in diabetic patients.

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Section: Mechanisms Contributing To Myocardial Dysfunction In Diabetimentioning

confidence: 99%

Section: Mechanisms Contributing To Myocardial Dysfunction In Diabetimentioning

confidence: 99%

Of mice and men: models and mechanisms of diabetic cardiomyopathy

2018

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“…These microRNAs exhibit essential roles in regulating genes related to the aforementioned pathophysiologic pathways of DCM including hypertrophy, apoptosis, and fibrosis. MicroRNA-9, 21, 29, 30d, 34a, 144, 150, 320, and 378 correlated strongly with DCM and could be used as potential serum biomarkers in patients with DCM [131]. Although it is not clear whether exercise can normalize certain microRNAs expression in the myocardium, it is exciting to consider that exercise might be able to restore the expression of some microRNAs through cross-talk effect.…”

Section: Prospective New Biomarkers In Dcmmentioning

confidence: 99%

Exercise as A Potential Therapeutic Target for Diabetic Cardiomyopathy: Insight into the Underlying Mechanisms

Seo

Jang

et al. 2019

IJMS

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Diabetes mellitus is associated with cardiovascular, ophthalmic, and renal comorbidities. Among these, diabetic cardiomyopathy (DCM) causes the most severe symptoms and is considered to be a major health problem worldwide. Exercise is widely known as an effective strategy for the prevention and treatment of many chronic diseases. Importantly, the onset of complications arising due to diabetes can be delayed or even prevented by exercise. Regular exercise is reported to have positive effects on diabetes mellitus and the development of DCM. The protective effects of exercise include prevention of cardiac apoptosis, fibrosis, oxidative stress, and microvascular diseases, as well as improvement in cardiac mitochondrial function and calcium regulation. This review summarizes the recent scientific findings to describe the potential mechanisms by which exercise may prevent DCM and heart failure.

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“…An miRNA is a small ncRNA molecule (containing about 22 nucleotides) found in plants, animals, and some viruses that functions in RNA silencing and posttranscriptional regulation of gene expression. Recently, miRNAs have been identified as a critical element involved in cardiac gene remodelling in diabetic heart . It has been shown that changes in synthesis and specific miRNA levels play a crucial role in the progress of cardiac remodelling and heart failure .…”

Section: The Possible Mechanism Of Lncrna In Dcmmentioning

confidence: 99%

“…Recently, miRNAs have been identified as a critical element involved in cardiac gene remodelling in diabetic heart. 154,155 It has been shown that changes in synthesis and specific miRNA levels play a crucial role in the progress of cardiac remodelling and heart failure. 156 Long noncoding RNAs can be used as a platform for the presentation of miRNAs to RNA binding proteins (RBPs) or mRNAs as intracellular, extracellular, or intercellular transporters.…”

Section: Lncrnas Regulation Relate To the Expression Of Dcm-relatedmentioning

confidence: 99%

Long noncoding RNAs: A new player in the prevention and treatment of diabetic cardiomyopathy?

Luo

Liu

et al. 2018

Diabetes Metabolism Res

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Diabetic cardiomyopathy (DCM) can cause extensive necrosis of the heart muscle by metabolic disorders and microangiopathy, with subclinical cardiac dysfunction, and eventually progress to heart failure, arrhythmia, and cardiogenic shock; severe patients may even die suddenly. Long noncoding RNAs (lncRNAs) are a class of nonprotein-coding RNAs longer than 200 nucleotides. They have critical roles in various biological processes, including gene expression regulation, genomic imprinting, nuclear-cytoplasmic trafficking, RNA splicing, and translational control. Recent studies indicated that lncRNAs extensively participate in the development of diverse cardiac diseases, such as cardiac ischaemia, hypertrophy, and heart failure. Little is known about lncRNA in DCM. In this review, we summarize the current literature on lncRNAs in DCM studies, aiming to provide new methods for DCM's future prevention and treatment strategies.

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Role of microRNA in diabetic cardiomyopathy: From mechanism to intervention

Cited by 79 publications

References 123 publications

Of mice and men: models and mechanisms of diabetic cardiomyopathy

Of mice and men: models and mechanisms of diabetic cardiomyopathy

Exercise as A Potential Therapeutic Target for Diabetic Cardiomyopathy: Insight into the Underlying Mechanisms

Long noncoding RNAs: A new player in the prevention and treatment of diabetic cardiomyopathy?

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