Role of microRNA Deregulation in Breast Cancer Cell Chemoresistance and Stemness

Tekiner, Tuğçe Ayça; Başağa, Hüveyda

doi:10.2174/09298673113209990003

Cited by 16 publications

(13 citation statements)

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“…MicroRNA (miRNA) belong to a class of conserved endogenous non‐coding small RNA, which negatively regulate gene expression at the post‐transcriptional level by matching to the 3'‐untranslated region (UTR), 5'‐UTR or coding region of mRNA . They are important regulators related to tumor malignant biobehaviors, including proliferation, invasion, metastasis, angiogenesis and chemoresistance . Recently, several groups have also reported aberrant expression of miRNA, such as miR‐7, miR‐21 and miR‐210 in the radioresistance of multiple cancers .…”

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confidence: 99%

miR‐185‐3p regulates nasopharyngeal carcinoma radioresistance by targeting WNT2B in vitro

et al. 2014

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Aberrant microRNA (miRNA) expression contributes to a series of malignant cancer behaviors, including radioresistance. Our previous study showed differential expression of miR-185-3p in post-radiation nasopharyngeal carcinoma (NPC) cells. To investigate the role of miR-185-3p in NPC radioresistance, CNE-2 and 5-8F cells were transfected with miR-185-3p mimic and miR-185-3p inhibitor, respectively. CCK-8 assay and colony formation experiment confirmed that the expression of miR-185-3p affected the radioresistance of NPC cells. A negative correlation between miR-185-3p and WNT2B expression was observed in NPC cells and tissues. Luciferase reporter assays confirmed that miR-185-3p directly targeted the coding region of WNT2B. Furthermore, we found radioresistance decreased in WNT2B-silenced NPC cells. Activation of the WNT2B/β-catenin pathway was accompanied by epithelial–mesenchymal transition biomarker changes in NPC. We concluded that miR-185-3p contributed to the radioresistance of NPC via modulation of WNT2B expression in vitro.

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confidence: 99%

miR‐185‐3p regulates nasopharyngeal carcinoma radioresistance by targeting WNT2B in vitro

et al. 2014

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“…Emerging evidence indicates that cancer stem cells or cancer‐initiating cells may contribute to radiation resistance of breast cancer . Deregulation of tumor‐associated miRNA, proteins and signal transduction pathways is involved in breast cancer chemoresistance . Trastuzumab resistance is partly induced by cancer‐associated fibroblasts through increasing cancer stem cells and activating multiple pathways in HER2‐positive breast cancer .…”

Section: Exosomes In Breast Cancer Resistancementioning

confidence: 99%

Exosomes in development, metastasis and drug resistance of breast cancer

et al. 2015

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Transport through the cell membrane can be divided into active, passive and vesicular types (exosomes). Exosomes are nano-sized vesicles released by a variety of cells. Emerging evidence shows that exosomes play a critical role in cancers. Exosomes mediate communication between stroma and cancer cells through the transfer of nucleic acid and proteins. It is demonstrated that the contents and the quantity of exosomes will change after occurrence of cancers. Over the last decade, growing attention has been paid to the role of exosomes in the development of breast cancer, the most life-threatening cancer in women. Breast cancer could induce salivary glands to secret specific exosomes, which could be used as biomarkers in the diagnosis of early breast cancer. Exosome-delivered nucleic acid and proteins partly facilitate the tumorigenesis, metastasis and resistance of breast cancer. Exosomes could also transmit anti-cancer drugs outside breast cancer cells, therefore leading to drug resistance. However, exosomes are effective tools for transportation of anti-cancer drugs with lower immunogenicity and toxicity. This is a promising way to establish a drug delivery system.

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“…These short RNAs behave as regulators of signaling pathways and are important key regulators in tumor progression [151].…”

Section: Hyperactivation Of Prosurvival Signaling Pathwaysmentioning

confidence: 99%

“…miR-7, miR-10, miR-15a, and miR-16 have been described to target MDR1, homeobox D10 (HOXD10), BCL-2, and cyclin-D1 (CCND1) genes, respectively, and induce resistance to cisplatin, taxol, tamoxifen, and docetaxel in breast cancer [151]. Altered expression of miRNA has been noted to induce chemotherapy resistance by targeting vital signaling molecules, such as phosphatase and tensin homolog (PTEN) and estrogen receptor (ESR) 1 in AKT, K-RAS and MAPK in PI3K/AKT signaling pathways, and BCL-6 and BCL-2 molecules.…”

Section: Hyperactivation Of Prosurvival Signaling Pathwaysmentioning

confidence: 99%

Mechanisms of tumor cell resistance to the current targeted-therapy agents

et al. 2016

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Resistance to chemotherapy agents is a major challenge infront of cancer patient treatment and researchers. It is known that several factors, such as multidrug resistance proteins and ATP-binding cassette families, are cell membrane transporters that can efflux several substrates such as chemotherapy agents from the cell cytoplasm. To reduce the adverse effects of chemotherapy agents, various targeted-based cancer therapy (TBCT) agents have been developed. TBCT has revolutionized cancer treatment, and several agents have shown more specific effects on tumor cells than chemotherapies. Small molecule inhibitors and monoclonal antibodies are specific agents that mostly target tumor cells but have low side effects on normal cells. Although these agents have been very useful for cancer treatment, however, the presence of natural and acquired resistance has blunted the advantages of targeted therapies. Therefore, development of new options might be necessary. A better understanding of tumor cell resistance mechanisms to current treatment agents may provide an appropriate platform for developing and improving new treatment modalities. Therefore, in this review, different mechanisms of tumor cell resistance to chemotherapy drugs and current targeted therapies have been described.

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Role of microRNA Deregulation in Breast Cancer Cell Chemoresistance and Stemness

Cited by 16 publications

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miR‐185‐3p regulates nasopharyngeal carcinoma radioresistance by targeting WNT2B in vitro

miR‐185‐3p regulates nasopharyngeal carcinoma radioresistance by targeting WNT2B in vitro

Exosomes in development, metastasis and drug resistance of breast cancer

Mechanisms of tumor cell resistance to the current targeted-therapy agents

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