Role of Micronutrients on Type Ii Diabetes Mellitus

Rajalakshmy, P.

doi:10.31080/asnh.2019.03.0444

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…There is an increasing accumulation of evidence linking micronutrient deficiency to diabetes both as a causative factor and as a consequence of the disease [ 71 ]. A systematic review and meta-analysis of the effects of individual micronutrients on blood pressure in patients with type 2 diabetes suggested that vitamin D and possibly vitamin C have beneficial effects on blood pressure, specifically in patients with type 2 diabetes [ 72 ].…”

Section: Role Of Nutrition In Healthy Ageing In Asiamentioning

confidence: 99%

The Role of Micronutrients in Ageing Asia: What Can Be Implemented with the Existing Insights

Inui¹,

Hanley

Tee

et al. 2021

Nutrients

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Life expectancy as a measure of population health does not reflect years of healthy life. The average life expectancy in the Asia-Pacific region has more than doubled since 1900 and is now above 70 years. In the Asia-Pacific region, the proportion of aged people in the population is expected to double between 2017 and 2050. Increased life expectancy leads to an increase in non-communicable diseases, which consequently affects quality of life. Suboptimal nutritional status is a contributing factor to the prevalence and severity of non-communicable diseases, including cardiovascular, cognitive, musculoskeletal, immune, metabolic and ophthalmological functions. We have reviewed the published literature on nutrition and healthy ageing as it applies to the Asia-Pacific region, focusing on vitamins, minerals/trace elements and omega-3 fatty acids. Optimal nutritional status needs to start before a senior age is reached and before the consequences of the disease process are irreversible. Based on the nutritional status and health issues in the senior age in the region, micronutrients of particular importance are vitamins A, D, E, C, B-12, zinc and omega-3 fatty acids. The present paper substantiates the creation of micronutrient guidelines and proposes actions to support the achievement of optimal nutritional status as contribution to healthy ageing for Asia-Pacific populations.

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Section: Role Of Nutrition In Healthy Ageing In Asiamentioning

confidence: 99%

The Role of Micronutrients in Ageing Asia: What Can Be Implemented with the Existing Insights

Inui¹,

Hanley

Tee

et al. 2021

Nutrients

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“…Several works explained the relation between the trace elements (Zn, Cr, and Mg) and the antidiabetic activity. ey explained also the deficiency of some trace elements in diabetic patients that play a great role in the development of diabetes mellitus [64][65][66][67]. Ahmed et al reported that several trace elements are significantly reduced in people with diabetes mellitus [67,68].…”

Section: 42mentioning

confidence: 99%

Characterization of an Endemic Plant Origanum grosii from Morocco: Trace Element Concentration and Antihyperglycemic Activities

Hassouni

hajji²,

Bnouham

et al. 2021

Journal of Chemistry

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Origanum genus is one of the most widely used herbs in folk medicine for its biological properties. The present investigation aims to characterize, for the first time, endemic Origanum grosii collected from the Taounate region, Morocco. This characterization was realized by determining the concentration of metals in different parts of the plant (flowers, leaves, and stems) by ICP-MS, and the results were studied statistically by Principal Component Analysis (PCA). Phytochemical screening with the dosage of polyphenols and flavonoids has been conducted. To know more about this species, antihyperglycemic tests have been performed to highlight the presence or absence of the antidiabetic effect for this plant. An Oral Glucose Tolerance Test (OGTT) has been performed on normal mice which were divided into two groups of six mice each. Group 1 (control group) was treated with distilled water, and group 2 was treated with an aqueous extract of O. grosii by gavage at 150 mg/kg. Digestive enzyme α-amylase inhibition assay has also been evaluated to study the inhibition effect of the studied extract using acarbose as a control. The results showed that the leaves exhibited a high concentration of trace elements (Ca, Mg, and K) and total absence of heavy metals, which were found in small quantities (Cr, Ni, and B) on the stems, and this makes the plant safe to use. On the other hand, tannins, flavonoids, triterpenes, and steroids were the major families strongly present in this species. The antidiabetic results showed that O. grosii have significantly reduced postprandial hyperglycemia after glucose loading in normal rats. It showed also that this species has a significant antihyperglycemic activity reflected by the inhibition of α-amylase. The one responsible for this property could be the synergy between the trace elements and the nature of the chemical families of O. grosii species, which can make this plant useful in the management of postprandial hyperglycemia.

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“…Oxidative stress significantly contributes to the pathophysiology of diabetes and its consequences 13 14. Micronutrients regulate the expression of genes, metabolism and the onset or progression of chronic diseases like diabetes.…”

Section: Introductionmentioning

confidence: 99%

“…Oxidative stress significantly contributes to the pathophysiology of diabetes and its consequences. 13 14 Micronutrients regulate the expression of genes, metabolism and the onset or progression of chronic diseases like diabetes. Micronutrient deficiencies of zinc, chromium, magnesium, copper, manganese and vitamin B are linked to glucose intolerance.…”

Section: Introductionmentioning

confidence: 99%

Hidden hunger in patients with type 2 diabetes (T2D) and its effect on glycaemic control: a protocol for systematic review and meta-analysis

Mangal,

Gautam,

Pandey

et al. 2024

BMJ Open

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IntroductionHidden hunger or micronutrient deficiencies are quite common in many parts of the world, particularly in the countries of sub-Saharan Africa and South Asia. Micronutrient deficiencies may impact insulin signalling pathways and glucose metabolism, potentially accelerating the onset and development of type 2 diabetes (T2D). This review aims to estimate the prevalence of multiple micronutrient deficiencies among patients with T2D and assess the effect of their deficiency on glycaemic control.MethodologyThe review follows the Cochrane Handbook and PRISMA 2020 guidelines. It includes all eligible studies reporting the prevalence of micronutrient deficiencies and their effect on glycaemic control in T2D patients. We would undertake a comprehensive literature search across databases: PubMed, Scopus, EMBASE, LILACS, ProQuest, Google Scholar and grey literature, and identify the studies meeting the inclusion criteria. We would perform data extraction using a prepiloted data extraction sheet and record relevant study characteristics and outcomes.AnalysisData will be analysed using JBI Sumari software and R software. Pooled prevalence/incidence of micronutrient deficiency will be estimated, and variance will be stabilised using logit transformation and a double-arcsine transformation of the data. The OR and risk ratio of glycaemic control among T2D cases with and without micronutrient deficiency will be estimated using the ‘rma’ function under the ‘meta’ and ‘metafor’ packages.The study findings will have implications for diabetes management strategies and may inform interventions targeting improved glycaemic control through addressing micronutrient deficiencies.Ethics and disseminationThis systematic review will be based on the scientific information available in the public domain; therefore, ethics approval is not required. We will share the study findings at national and international conferences and submit them for publication in relevant scientific journals.PROSPERO registration numberCRD42023439780.

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Role of Micronutrients on Type Ii Diabetes Mellitus

Cited by 4 publications

References 8 publications

The Role of Micronutrients in Ageing Asia: What Can Be Implemented with the Existing Insights

The Role of Micronutrients in Ageing Asia: What Can Be Implemented with the Existing Insights

Characterization of an Endemic Plant Origanum grosii from Morocco: Trace Element Concentration and Antihyperglycemic Activities

Hidden hunger in patients with type 2 diabetes (T2D) and its effect on glycaemic control: a protocol for systematic review and meta-analysis

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