Role of microbiological tests in diagnosis of genital tuberculosis of women with infertility: A view

Agrawal, Manindra; Roy, Partha; Bhatia, Vinay; Dutt, Sarjana; Gaur, Rajiv L.

doi:10.1016/j.ijtb.2019.03.003

Cited by 7 publications

(2 citation statements)

References 13 publications

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“…Similar result was found in Bharti Malhotra et al 28 where TB-PCR was positive in 23.78% and in study of Goel et al 29 TB-PCR was positive in 22.2%. In two separate study, Monika et al 31 and Indu Goutam & group 35 were found positive in 3.6% and 10 % of cases respectively for TB-PCR which were lower than those in our study. In a study PCR was found positive result in 38.5% samples whereas Gunjan Sribastava et al 36 found 86% samples positive by PCR.…”

Section: Discussioncontrasting

confidence: 77%

Evaluation of culture, molecular assay (TB-PCR), GeneXpert system and histopathology for detection of genital tuberculosis

Das¹,

Mahata

Gupta³

2022

PJMS

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Female genital tuberculosis (FGTB) has a crucial role in many gynaecological complaint and delay in diagnosis can cause irreversible damages. The new diagnostic technique GeneXpert system is accurate and rapid test can make paradigm shift in FGTB treatment. The aim of the study to estimate efficacy of different tests i.e. AFB BACTEC culture, molecular assay (TB-PCR) and histopathology in comparison to GeneXpert system to detect FGTB. The prospective observational study was conducted in between January, 2018 and June, 2019. Randomly selected total 62 patients were put under all four diagnostic tests from endometrial sampling. The positivity of genital TB and efficacy of the tests were compared with test result of GeneXpert assay.In our study, out of 62 patients, most commonly 33.9% were each from age group of 21-30 and 31-40 years i.e. reproductive ages, 45.2% were overweight, primary infertility of 48.4% patients were predominant symptomatology. Overall positivity by GeneXpert test was 21% (3/62), histopathology 8.1% (5/62), AFB BACTEC culture 12.9% (8/62) and 24.2% (15/62%) by molecular assay (TB-PCR). On evaluating against our diagnostic tests, specificity of histopathology, AFB BACTEC Culture and TB-PCR was 97.96%, 95.92% and 75.51%. The diagnostic tests were analysed by Kappa measure agreement in comparison to GeneXpert assay. The histopathology and AFB BACTEC Culture showed fair and moderate agreement respectively, but on the contrary TB-PCR have not showed any agreement with GeneXpert assay.High degree of suspicion and battery of tests needed for diagnosis of genital TB. Rapid diagnosis by GeneXpert assay may play a crucial role in TB control programme. Female genital tuberculosis (FGTB) has a crucial role in many gynaecological complaint and delay in diagnosis can cause irreversible damages. The new diagnostic technique GeneXpert system is accurate and rapid test can make paradigm shift in FGTB treatment.

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Section: Discussioncontrasting

confidence: 77%

Evaluation of culture, molecular assay (TB-PCR), GeneXpert system and histopathology for detection of genital tuberculosis

Das¹,

Mahata

Gupta³

2022

PJMS

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“…Incidence of infertility in developed communities is reported on a rise from those in developing countries 5,6 . Tuberculosis is considered among the major causes of infertility on a global basis along with post abortion and postpartum infections 7 . An accurate diagnosis is the first step…”

Section: Introductionmentioning

confidence: 99%

Frequency of Genital Tuberculosis in Patients Undergoing Diagnostic Laparoscopy for Infertility

Niaz

Khan

2022

J Gandhara Med Dent Sci

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OBJECTIVES: To determine the frequency of genital tuberculosis in patients undergoing diagnostic laparoscopy for infertility. METHODOLOGY: It is a descriptive (cross-sectional) prospective study. The study was performed within the duration of six months i.e., February 12th, 2020 to August 12th, 2020 at the Department of Obstetrics and Gynecology, Khyber Teaching Hospital, Peshawar. A total of 196 patients were observed by using 47.1% proportion of genital tuberculosis in infertility, 95% confidence interval with margin of error 7%, using software of WHO for sample size calculation. Further, sample collection was performed using non-probability (consecutive) sampling techniques. RESULTS: The mean age of the patients in our study was 30 years (SD+3.92). Fifty seven percent of cases were having primary infertility and 43% of patients were having secondary infertility. The incidence of genital tuberculosis undergoing infertility was 45%. CONCLUSION: Our study concludes that the incidence of genital TB in infertility in our setup was 45%.

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Genital tb-diagnostic algorithm and treatment

Sharma

et al. 2020

Indian Journal of Tuberculosis

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Role of microbiological tests in diagnosis of genital tuberculosis of women with infertility: A view

Cited by 7 publications

References 13 publications

Evaluation of culture, molecular assay (TB-PCR), GeneXpert system and histopathology for detection of genital tuberculosis

Evaluation of culture, molecular assay (TB-PCR), GeneXpert system and histopathology for detection of genital tuberculosis

Frequency of Genital Tuberculosis in Patients Undergoing Diagnostic Laparoscopy for Infertility

Genital tb-diagnostic algorithm and treatment

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