Role of micellar interface in the synthesis of chitosan nanoparticles formulated by reverse micellar method

Orellano, María Soledad; Longo, Gabriel S.; Porporatto, Carina; Correa, N. Mariano; Falcone, R. Darío

doi:10.1016/j.colsurfa.2020.124876

Cited by 36 publications

(18 citation statements)

References 75 publications

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“…To avoid turbidity, an aqueous chitosan solution was added while continuously stirring. Under steady stirring, a crosslinking agent was added to this translucent solution [66]. Previous research employing Na 1,4-bis-2-ethylhexyl sulfosuccinate reverse micelles as very small reactors showed that the final molecule dimension could be affected by adjusting the reagent concentration and reverse micelles water amount.…”

Section: Reverse Micelle Methodsmentioning

confidence: 99%

Retracted: Advances in chitosan biopolymer composite materials: from bioengineering, wastewater treatment to agricultural applications

Chadha

Bhardwaj

Selvaraj

et al. 2022

Mater. Res. Express

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Chitosan has become the most known and second abundantly available recyclable, non-hazardous and eco-friendly biopolymer after cellulose with several advantageous biomedical, agriculture, and wastewater treatment applications. As nanotechnology has progressed, researchers have begun incorporating chitosan-based carbon compounds into various compounds, elements, and carbonaceous materials to increase their efficiency and biocompatibility. Chitosan carbon compounds have also been used directly in many applications due to their inherent chelating and antibacterial features and the presence of customizable functional groups. In this review, synthesis technologies and microstructure of chitosan composites and its carbon materials in biomedical, agriculture, and wastewater treatment concerning the administration of abiotic stress within plants, water accessibility for crops, scheming food bear pathogens, photothermal cancer rehabilitation, and heavy water pollutants absorption and removal methods are widely deliberated upon, with a relevant discussion of the techniques that can be used to put these into action. Chitosan is also utilized in miscellaneous applications, including the food sector and cosmetics. Overall, chitosan-based carbon compounds promise to extend agricultural practices while also addressing health concerns in an environmentally friendly manner.

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Section: Reverse Micelle Methodsmentioning

confidence: 99%

Retracted: Advances in chitosan biopolymer composite materials: from bioengineering, wastewater treatment to agricultural applications

Chadha

Bhardwaj

Selvaraj

et al. 2022

Mater. Res. Express

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“…Orellano et al [90] studied the effect of the micellar interface on the synthesis of CS NPs. Both benzyl-n-hexadecyltrimethylammonium chloride (BHDC) and 1,4-bis-2ethylhexylsulfosuccinate (AOT) reverse micelles were assessed since there were found remarkable differences between their interfacial water entrapped structures.…”

Section: Reverse Micellar Methodsmentioning

confidence: 99%

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

248

120

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Nanoparticles (NPs) have an outstanding position in pharmaceutical, biological, and medical disciplines. Polymeric NPs based on chitosan (CS) can act as excellent drug carriers because of some intrinsic beneficial properties including biocompatibility, biodegradability, non-toxicity, bioactivity, easy preparation, and targeting specificity. Drug transport and release from CS-based particulate systems depend on the extent of cross-linking, morphology, size, and density of the particulate system, as well as physicochemical properties of the drug. All these aspects have to be considered when developing new CS-based NPs as potential drug delivery systems. This comprehensive review is summarizing and discussing recent advances in CS-based NPs being developed and examined for drug delivery. From this point of view, an enhancement of CS properties by its modification is presented. An enhancement in drug delivery by CS NPs is discussed in detail focusing on (i) a brief summarization of basic characteristics of CS NPs, (ii) a categorization of preparation procedures used for CS NPs involving also recent improvements in production schemes of conventional as well as novel CS NPs, (iii) a categorization and evaluation of CS-based-nanocomposites involving their production schemes with organic polymers and inorganic material, and (iv) very recent implementations of CS NPs and nanocomposites in drug delivery.

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“…Then, the organic solvent is evaporated, and the yield nanoparticles can be harvested by precipitation with a suitable salt ( Figure 6 ) [ 75 ]. The advantages of this method are associated with the ability of production of small particle size with a narrow size of distribution [ 76 ], while the disadvantages including the laborious and time-consuming process and the presence of organic solvent and surfactant.…”

Section: Preparation Methods Of Chitosan Nanoparticlesmentioning

confidence: 99%

Recent Progress of Chitosan and Chitosan Derivatives-Based Nanoparticles: Pharmaceutical Perspectives of Oral Insulin Delivery

2020

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Diabetes mellitus is a chronic endocrine disease, affecting more than 400 million people around the world. Patients with poorly controlled blood glucose levels are liable to suffer from life-threatening complications, such as cardiovascular, neuropathy, retinopathy and even premature death. Today, subcutaneous parenteral is still the most common route for insulin therapy. Oral insulin administration is favourable and convenient to the patients. In contrast to injection route, oral insulin delivery mimics the physiological pathway of endogenous insulin secretion. However, oral insulin has poor bioavailability (less than 2%) due to the harsh physiological environment through the gastrointestinal tract (GIT). Over the last few decades, many attempts have been made to achieve an effective oral insulin formulation with high bioavailability using insulin encapsulation into nanoparticles as advanced technology. Various natural polymers have been employed to fabricate nanoparticles as a delivery vehicle for insulin oral administration. Chitosan, a natural polymer, is extensively studied due to the attractive properties, such as biodegradability, biocompatibility, bioactivity, nontoxicity and polycationic nature. Numerous studies were conducted to evaluate chitosan and chitosan derivatives-based nanoparticles capabilities for oral insulin delivery. This review highlights strategies that have been applied in the recent five years to fabricate chitosan/chitosan derivatives-based nanoparticles for oral insulin delivery. A summary of the barriers hurdle insulin absorption rendering its low bioavailability such as physical, chemical and enzymatic barriers are highlighted with an emphasis on the most common methods of chitosan nanoparticles preparation. Nanocarriers are able to improve the absorption of insulin through GIT, deliver insulin to the blood circulation and lower blood glucose levels. In spite of some drawbacks encountered in this technology, chitosan and chitosan derivatives-based nanoparticles are greatly promising entities for oral insulin delivery.

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Role of micellar interface in the synthesis of chitosan nanoparticles formulated by reverse micellar method

Cited by 36 publications

References 75 publications

Retracted: Advances in chitosan biopolymer composite materials: from bioengineering, wastewater treatment to agricultural applications

Retracted: Advances in chitosan biopolymer composite materials: from bioengineering, wastewater treatment to agricultural applications

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Recent Progress of Chitosan and Chitosan Derivatives-Based Nanoparticles: Pharmaceutical Perspectives of Oral Insulin Delivery

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