Role of metal Cu(II) and Ag(I) on molecular structure of 4-amino-N-(2, 6-dimethoxypyrimidin-4-yl) benzenesulfonamide in presence of 3-methyl pyridine: Synthesis, spectral, crystallographic and DNA interaction studies

Socha, Bhavesh N.; Patel, Urmila H.; Pandya, Sachin B.; Chavda, Bhavin R.; Chaudhary, Kaushik P.; Patel, B. H.; Patel, Rasmika H.; Patel, Nikita; Bhatt, Bhupesh S.

doi:10.1016/j.poly.2020.114696

Cited by 20 publications

(3 citation statements)

References 43 publications

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“…The relative viscosity of the DNA solution increases with an increase in the concentration of Ni-complex, which is the result of an increase in the size of the DNA chain due to intercalation (Figure S5 ). Similar kinds of results are observed in the case of reported metal complexes and classical intercalator, EtBr and the data are supporting the UV–visible absorption titration study 55 , 87 , 88 , 92 .…”

Section: Resultssupporting

confidence: 90%

Visible light-driven photocatalysts, quantum chemical calculations, ADMET-SAR parameters, and DNA binding studies of nickel complex of sulfadiazine

Pandya,

Socha,

Dubey

et al. 2023

Sci Rep

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A 3D-supramolecular nickel integrated Ni-SDZ complex was synthesized using sodium salt of sulfadiazine as the ligand and nickel(II) acetate as the metal salt using a condensation process and slow evaporation approach to growing the single crystal. The metal complex was characterized for its composition, functional groups, surface morphology as well as complex 3D structure, by resorting to various analytical techniques. The interacting surface and stability as well as reactivity of the complex were carried out using the DFT platform. From ADMET parameters, human Intestinal Absorbance data revealed that the compound has the potential to be well absorbed, and also Ni-SDZ complex cannot cross the blood–brain barrier (BBB). Additionally, the complex's DNA binding affinity and in-vivo and in-vitro cytotoxic studies were explored utilizing UV–Vis absorbance titration, viscosity measurements, and S. pombe cells and brine shrimp lethality tests. In visible light radiation, the Ni-SDZ complex displayed exceptional photo-degradation characteristics of approximately 70.19% within 70 min against methylene blue (MB).

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Section: Resultssupporting

confidence: 90%

Visible light-driven photocatalysts, quantum chemical calculations, ADMET-SAR parameters, and DNA binding studies of nickel complex of sulfadiazine

Pandya,

Socha,

Dubey

et al. 2023

Sci Rep

Self Cite

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“…The LC50 (50% lethal concentration) value of the complex had been obtained from the plot of % of the brine shrimp nauplii killed against the complex concentrations and the best-fit line was found from the data through regression analysis. The significant LC50 value of the free Sulfamithoxazole (SMX) drug and its Ag-SMX complex are 12.88 μM and 6.30 μM respectively, predicting higher toxicity of SMX molecule than that of Ag-SMX complex and also, Ag-SMX complex displays less toxic behaviour compared to reported data of Cd sulfapyridine (8.32 μM) and Zn-sulfapyridine (6.31 μM) complexes [12].…”

Section: Resultsmentioning

confidence: 88%

“…Usually, cells undergoing necrosis show accelerated swelling, lose the cohesion of the membrane, shut down metabolism, and release their contents into the atmosphere. Cells undergoing rapid in vitro necrosis do not have enough time or resources to activate the apoptotic machinery and do not produce apoptotic markers [11][12][13]. Apoptosis is distinguished by well-defined cytological and molecular events, including cell refractive index transition, cytoplasmic shrinkage, nuclear condensation, and regular fragment cleavage of DNA.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity Study

Chavda¹,

Socha²

2021

Cytotoxicity - New Insights Into Toxic Assessment

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The nature of being poisonous to cells is cytotoxicity. A number of cell fates can result in the treatment of cells with a cytotoxic compound. In this study, the nauplii were exposed to different concentrations of compounds for 24 hours. Experiments were concluded with control and different concentration of the compound. The whole set was triplicate to get an accurate result. The LC50 was determined from the best fit line, of a graph of % mortality vs. concentration of nauplii. The LC50 value was obtained from the antilogarithm of log [complex] at 50% mortality (LC50), all data were collected from three independent experiments.

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Silver-Based 3D-Supramolecular Metal–Organic Framework: Crystallographic Evaluation, Antibiotic, Anticancer, and Visible-Light-Driven Photocatalytic Activity

Socha,

Pandya,

Patel

et al. 2023

J Inorg Organomet Polym

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Role of metal Cu(II) and Ag(I) on molecular structure of 4-amino-N-(2, 6-dimethoxypyrimidin-4-yl) benzenesulfonamide in presence of 3-methyl pyridine: Synthesis, spectral, crystallographic and DNA interaction studies

Cited by 20 publications

References 43 publications

Visible light-driven photocatalysts, quantum chemical calculations, ADMET-SAR parameters, and DNA binding studies of nickel complex of sulfadiazine

Visible light-driven photocatalysts, quantum chemical calculations, ADMET-SAR parameters, and DNA binding studies of nickel complex of sulfadiazine

Cytotoxicity Study

Silver-Based 3D-Supramolecular Metal–Organic Framework: Crystallographic Evaluation, Antibiotic, Anticancer, and Visible-Light-Driven Photocatalytic Activity

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