Role of Metabolism in Bone Development and Homeostasis

Suzuki, Akiko; Minamide, Mina; Iwaya, Chihiro; Ogata, Kenichi; Iwata, Junichi

doi:10.3390/ijms21238992

Cited by 61 publications

(46 citation statements)

References 197 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, lipids and their derivatives can activated osteoblasts via selective lipid receptors and catabolic enzymes for the internalization and utilization of circulating lipids. Dyslipidaemia and lipid homeostasis disruption can impair osteoblast function and accelerate osteoclast activity 5,6 . Targeting lipid metabolism with a statin has been shown to improve bone density and quality in metabolic bone diseases 7 …”

Section: Introductionmentioning

confidence: 99%

The role of statins in the differentiation and function of bone cells

Chamani

Liberale

Mobasheri

et al. 2021

Eur J Clin Investigation

View full text Add to dashboard Cite

Background Statins are 3‐Hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase inhibitors blocking cholesterol biosynthesis in hepatic cells, thereby causing an increase in low‐density lipoprotein (LDL) receptors resulting in enhanced uptake and clearance of atherogenic LDL‐cholesterol (LDL‐C) from the blood. Accordingly, statins decrease the risk of developing atherosclerosis and its acute complications, such as acute myocardial infarction and ischaemic stroke. Besides the LDL‐C‐lowering impact, statins also have other so‐called pleiotropic effects. Among them, the ability to modulate differentiation and function of bone cells and exert direct effects on osteosynthesis factors. Specifically, earlier studies have shown that statins cause in vitro and in vivo osteogenic differentiation. Design The most relevant papers on the bone‐related ‘pleiotropic’ effects of statins were selected following literature search in databases and were reveiwed. Results Statins increase the expression of many mediators involved in bone metabolism including bone morphogenetic protein‐2 (BMP‐2), glucocorticoids, transforming growth factor‐beta (TGF‐β), alkaline phosphatase (ALP), type I collagen and collagenase‐1. As a result, they enhance bone formation and improve bone mineral density by modulating osteoblast and osteoclast differentiation. Conclusion This review summarizes the literature exploring bone‐related ‘pleiotropic’ effects of statins and suggests an anabolic role in the bone tissue for this drug class. Accordingly, current knowledge encourages further clinical trials to assess the therapeutic potential of statins in the treatment of bone disorders, such as arthritis and osteoporosis.

show abstract

Section: Introductionmentioning

confidence: 99%

The role of statins in the differentiation and function of bone cells

Chamani

Liberale

Mobasheri

et al. 2021

Eur J Clin Investigation

View full text Add to dashboard Cite

show abstract

“…Despite all the analysis carried out in this study, we can consider as a limitation the failure to perform an immunohistochemical analysis, which would favor the understanding of bone formation. Furthermore, it could be associated with metabolic dysfunction with alcohol consumption and its influence on the bone repair process [51,52]. There is a need for further studies as the number of patients who receive orthopedic and dental procedures, and who chronically use alcoholic beverages, has increased considerably.…”

Section: Discussionmentioning

confidence: 99%

Biological Behavior of Xenogenic Scaffolds in Alcohol-Induced Rats: Histomorphometric and Picrosirius Red Staining Analysis

et al. 2022

View full text Add to dashboard Cite

In this experimental protocol, the objective was to evaluate the biological behavior of two xenogenic scaffolds in alcohol-induced rats through histomorphometric and Picrosirius Red staining analysis of non-critical defects in the tibia of rats submitted or not to alcohol ingestion at 25% v/v. Eighty male rats were randomly divided into four groups (n = 20 each): CG/B (water diet + Bio-Oss® graft, Geistlich Pharma AG, Wolhusen, Switzerland), CG/O (water diet + OrthoGen® graft, Baumer, Mogi Mirim, Brazil), AG/B (25% v/v alcohol diet + Bio-Oss® graft), and AG/O (25% v/v alcohol diet + OrthoGen® graft). After 90 days of liquid diet, the rats were surgically obtained, with a defect in the tibia proximal epiphysis; filled in according to their respective groups; and euthanized at 10, 20, 40 and 60 days. In two initial periods (10 and 20 days), all groups presented biomaterial particles surrounded by disorganized collagen fibrils. Alcoholic animals (AG/B and AG/O) presented, in the cortical and medullary regions, a reactive tissue with inflammatory infiltrate. In 60 days, in the superficial area of the surgical cavities, particles of biomaterials were observed in all groups, with new compact bone tissue around them, without complete closure of the lesion, except in non-alcoholic animals treated with Bio-Oss® xenograft (CG/B), where the new cortical interconnected the edges of the defect. Birefringence transition was observed in the histochemical analysis of collagen fibers by Picrosirius Red, in which all groups in periods of 10 and 20 days showed red-orange birefringence, and from 40 days onwards greenish-yellow birefringence, which demonstrates the characteristic transition from the formation of thin and disorganized collagen fibers initially to more organized and thicker later. In histomorphometric analysis, at 60 days, CG/B had the highest volume density of new bone (32.9 ± 1.15) and AG/O the lowest volume density of new bone (15.32 ± 1.71). It can be concluded that the bone neoformation occurred in the defects that received the two biomaterials, in all periods, but the Bio-Oss® was superior in the results, with its groups CG/B and AG/B displaying greater bone formation (32.9 ± 1.15 and 22.74 ± 1.15, respectively) compared to the OrthoGen® CG/O and AG/O groups (20.66 ± 2.12 and 15.32 ± 1.71, respectively), and that the alcoholic diet interfered negatively in the repair process and in the percentage of new bone formed.

show abstract

“…To sustain a suitable blood calcium level, bones may breakdown and bring calcium into the blood [33]. Therefore, bone may be porous and prone to fractures [31,[34][35]. In addition, recent research also found hypertension corresponded with the low level of 25-hydroxy vitamin D and osteocalcin, which leaded to a low bone turnover [11].…”

Section: Discussionmentioning

confidence: 99%

Gender-Difference Association Between Blood Pressure And Osteoporosis: Results From Henan Rural Cohort Study

Tian

Chen

et al. 2022

Preprint

View full text Add to dashboard Cite

Purpose: Accumulating researches have observed the potential association between osteoporosis and hypertension, however, the evidence regarding gender-difference association between divergent proxies of blood pressure and osteoporosis was limited in rural areas.Methods: A total of 7689 participants enrolled from Henan Rural Cohort study were included in this research. Four proxies (systolic blood pressure (SBP); diastolic blood pressure (DBP); mean arterial pressure (MAP); pulse pressure (PP)) of blood pressure were measured. The association between blood pressure and osteoporosis was assessed by binary logistic regression with adjustment of potential influencing factors. All analyses were stratified by gender. To test the robust of results, similar analyses were also conducted in non-hypertension participants and postmenopausal women. Results: The significantly positive association between hypertension and osteoporosis was observed among women but not in men. Increasing blood pressure corresponded with prevalent osteoporosis among women, in which each 10 mmHg increase in SBP, MAP, and PP corresponded with 1.07-fold (1.03, 1.12), 1.14-fold (1.07, 1.21), and 1.08-fold (1.02, 1.15) prevalence of osteoporosis, respectively. This positive association was still significant among non-hypertension women and postmenopausal women, but not in pre-menopausal women.Conclusion: In rural areas, there was a positive association between blood pressure and prevalent osteoporosis in women, but not in men. Menopausal status may be responsible for this gender-difference.

show abstract

Role of Metabolism in Bone Development and Homeostasis

Cited by 61 publications

References 197 publications

The role of statins in the differentiation and function of bone cells

The role of statins in the differentiation and function of bone cells

Biological Behavior of Xenogenic Scaffolds in Alcohol-Induced Rats: Histomorphometric and Picrosirius Red Staining Analysis

Gender-Difference Association Between Blood Pressure And Osteoporosis: Results From Henan Rural Cohort Study

Contact Info

Product

Resources

About